BioPAX pathway converted from "PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane" in the Reactome database. 3.1.3.36 PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Reactome DB_ID: 29356 1 cytosol GO 0005829 water [ChEBI:15377] water Reactome http://www.reactome.org ChEBI 15377 Reactome DB_ID: 1806165 1 Golgi membrane GO 0000139 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate [ChEBI:18348] 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate PIP2 ChEBI 18348 Reactome DB_ID: 1806217 1 1-phosphatidyl-1D-myo-inositol 4-phosphate [ChEBI:17526] 1-phosphatidyl-1D-myo-inositol 4-phosphate ChEBI 17526 Reactome DB_ID: 29372 1 hydrogenphosphate [ChEBI:43474] hydrogenphosphate [PO3(OH)](2-) HYDROGENPHOSPHATE ION hydrogen phosphate [P(OH)O3](2-) HPO4(2-) phosphate INORGANIC PHOSPHATE GROUP ChEBI 43474 PHYSIOL-LEFT-TO-RIGHT ACTIVATION Reactome DB_ID: 10623732 UniProt:O17590 ocrl-1 Caenorhabditis elegans NCBI Taxonomy 6239 UniProt O17590 Chain Coordinates 1 EQUAL 901 EQUAL GO 0004439 GO molecular function Reactome Database ID Release 78 10623733 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10623733 Reactome Database ID Release 78 10623735 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10623735 Reactome R-CEL-1675824 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-1675824.1 At the Golgi membrane, phosphatidylinositol 4-phosphate (PI4P) inositol polyphosphate 5-phosphatase OCRL-1 (OCRL) (Choudhury et al. 2009, Suchy et al. 1995, Zhang et al. 1995) and 72 kDa inositol polyphosphate 5-phosphatase (INPP5E) (Bilas et al. 2009) dephosphorylate phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) to form phosphatidylinositol 4-phosphate (PI4P). INPP5E is located in the Golgi membrane, mediated by its N-terminal proline-rich domain (Kong et al. 2000). 8634694 Pubmed 1995 Lowe syndrome, a deficiency of phosphatidylinositol 4,5-bisphosphate 5-phosphatase in the Golgi apparatus Suchy, SF Olivos-Glander, IM Nussabaum, RL Hum Mol Genet 4:2245-50 10764818 Pubmed 2000 The isolation and characterization of a cDNA encoding phospholipid-specific inositol polyphosphate 5-phosphatase Kisseleva, MV Wilson, MP Majerus, PW J Biol Chem 275:20110-6 10806194 Pubmed 2000 Cloning and characterization of a 72-kDa inositol-polyphosphate 5-phosphatase localized to the Golgi network Kong, AM Speed, CJ O'Malley, CJ Layton, MJ Meehan, T Loveland, KL Cheema, S Ooms, LM Mitchell, CA J Biol Chem 275:24052-64 19211563 Pubmed 2009 Differential clathrin binding and subcellular localization of OCRL1 splice isoforms Choudhury, R Noakes, CJ McKenzie, E Kox, C Lowe, M J Biol Chem 284:9965-73 7761412 Pubmed 1995 The protein deficient in Lowe syndrome is a phosphatidylinositol-4,5-bisphosphate 5-phosphatase Zhang, Xiaoxuan Jefferson, AB Auethavekiat, V Majerus, PW Proc Natl Acad Sci U S A 92:4853-6 19668216 Pubmed 2009 Mutations in INPP5E, encoding inositol polyphosphate-5-phosphatase E, link phosphatidyl inositol signaling to the ciliopathies Bielas, SL Silhavy, JL Brancati, Francesco Kisseleva, MV Al-Gazali, Lihadh Sztriha, L Bayoumi, RA Zaki, MS Abdel-Aleem, Alice Rosti, RO Kayserili, Hulya Swistun, D Scott, LC Bertini, E Boltshauser, E Fazzi, E Travaglini, L Field, SJ Gayral, S Jacoby, M Schurmans, S Dallapiccola, B Majerus, PW Valente, EM Gleeson, JG Nat Genet 41:1032-6 inferred by electronic annotation IEA GO IEA