BioPAX pathway converted from "CDK1 phosphorylates MAPK6" in the Reactome database.2.7.11.22CDK1 phosphorylates MAPK6CDK1 phosphorylates MAPK6This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>Reactome DB_ID: 293584nucleoplasmGO0005654ATP(4-) [ChEBI:30616]ATP(4-)Adenosine 5'-triphosphateatpATPReactomehttp://www.reactome.orgChEBI30616Converted from EntitySet in ReactomeReactome DB_ID: 106232311Homologues of MAPK6 [nucleoplasm]Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntityMAPK6 [nucleoplasm]MAPK6 [nucleoplasm]pmk-3 [nucleoplasm]MAPK6 [nucleoplasm]mpk-2 [nucleoplasm]sma-5 [nucleoplasm]MAPK6 [nucleoplasm]MAPK6 [nucleoplasm]gska-3 [nucleoplasm]MAPK6 [nucleoplasm]Caenorhabditis elegansNCBI Taxonomy6239UniProtG5EFV1UniProtQ9XX60UniProtO44514UniProtQ9XXC0UniProtH2KYF8UniProtG5EBT1UniProtP91267UniProtQ19243UniProtQ93344UniProtQ9U3L3Converted from EntitySet in ReactomeReactome DB_ID: 106243051Homologues of p-3S,T MAPK6 [nucleoplasm]Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntityphospho-p-3S,T MAPK6 [nucleoplasm]phospho-p-3S,T MAPK6 [nucleoplasm]phospho-p-3S,T MAPK6 [nucleoplasm]phospho-p-3S,T MAPK6 [nucleoplasm]phospho-mpk-2 [nucleoplasm]phospho-gska-3 [nucleoplasm]phospho-sma-5 [nucleoplasm]phospho-pmk-3 [nucleoplasm]phospho-p-3S,T MAPK6 [nucleoplasm]phospho-p-3S,T MAPK6 [nucleoplasm]Reactome DB_ID: 1135824ADP(3-) [ChEBI:456216]ADP(3-)ADP trianion5&apos;-O-[(phosphonatooxy)phosphinato]adenosineADPChEBI456216PHYSIOL-LEFT-TO-RIGHTACTIVATIONReactome DB_ID: 10579982UniProt:P34556cdk-1UniProtP34556O-phospho-L-threonine at 161 (in Homo sapiens)161EQUALO-phospho-L-threonine [MOD:00047]Chain Coordinates1EQUAL297EQUALGO0004693GO molecular functionReactome Database ID Release 7510624319Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10624319Reactome Database ID Release 7510624321Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10624321ReactomeR-CEL-56927551Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-5692755.1MAPK6 is hyperphosphorylated by CDK1 at multiple sites in the C-terminal extension, and this phosphorylation is associated with the stabilization of MAPK6 protein in mitosis. Residues S684, S688, T698 and S705 have been identified as in vitro targets of CDK1, and phosphorylation of T698 has also been demonstrated in vivo (Tanguay et al, 2010). The role of hyperphosphorylated MAPK6 during mitosis has not been established, and although the CDK1-dependent phosphorylation of MAPK6 is depicted as occuring in the nucleus, the site of action has also not been determined. CDK1-dependent hyperphosphorylation of the C-terminal tail is reversed by the phosphatases CDC14A and B (Tanguay et al, 2010; Hansen et al, 2008).20236090Pubmed2010C-terminal domain phosphorylation of ERK3 controlled by Cdk1 and Cdc14 regulates its stability in mitosisTanguay, Pierre-LucRodier, GenevièveMeloche, SylvainBiochem. J. 428:103-1118235225Pubmed2008A functional link between the human cell cycle-regulatory phosphatase Cdc14A and the atypical mitogen-activated kinase Erk3Hansen, Christina AaenBartek, JiriJensen, SanneCell Cycle 7:325-34inferred by electronic annotationIEAGOIEA