BioPAX pathway converted from "CFTR transits to the plasma membrane" in the Reactome database.CFTR transits to the plasma membraneCFTR transits to the plasma membraneThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>Converted from EntitySet in ReactomeReactome DB_ID: 106350911endoplasmic reticulum membraneGO0005789Homologues of misfolded CFTR [endoplasmic reticulum membrane]Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntitymrp-6 [endoplasmic reticulum membrane]cft-1 [endoplasmic reticulum membrane]mrp-5 [endoplasmic reticulum membrane]Reactomehttp://www.reactome.orgCaenorhabditis elegansNCBI Taxonomy6239UniProtQ19625UniProtQ95QV2UniProtG5EE72Converted from EntitySet in ReactomeReactome DB_ID: 105900501plasma membraneGO0005886Homologues of CFTR [plasma membrane]Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntitycft-1 [plasma membrane]mrp-6 [plasma membrane]mrp-5 [plasma membrane]Reactome Database ID Release 7510635142Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10635142ReactomeR-CEL-88668511Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-8866851.1The cystic fibrosis transmembrane conductance regulator (CFTR) is a cAMP-regulated chloride ion channel that undergoes multiple folding processes and post-translational modifications during its biosynthesis. 60-80% of CFTR protein encoded by the wild-type (WT) gene is successfully modified and transits the secretory system to the plasma membrane. The remaining misfolded protein is targeted for degradation by the ER, lysosomes or autophagy (reviewed in Pranke and Sermet-Gaudelus, 2014)24685677Pubmed2014Biosynthesis of cystic fibrosis transmembrane conductance regulatorPranke, Iwona MSermet-Gaudelus, IsabelleInt. J. Biochem. Cell Biol. 52:26-38inferred by electronic annotationIEAGOIEA