BioPAX pathway converted from "NUMB binds ITCH" in the Reactome database. NUMB binds ITCH NUMB binds ITCH This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Reactome DB_ID: 10612204 1 plasma membrane GO 0005886 UniProt:Q9XTY6 num-1 Reactome http://www.reactome.org Caenorhabditis elegans NCBI Taxonomy 6239 UniProt Q9XTY6 Chain Coordinates 1 EQUAL 651 EQUAL Reactome DB_ID: 10618064 1 cytosol GO 0005829 UniProt:Q9N2Z7 wwp-1 UniProt Q9N2Z7 1 EQUAL 903 EQUAL Reactome DB_ID: 10635233 1 NUMB:ITCH [cytosol] NUMB:ITCH Reactome DB_ID: 10612204 1 1 EQUAL 651 EQUAL Reactome DB_ID: 10618064 1 1 EQUAL 903 EQUAL Reactome Database ID Release 78 10635233 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10635233 Reactome R-CEL-5610562 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-5610562.1 Reactome Database ID Release 78 10635235 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10635235 Reactome R-CEL-5610735 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-5610735.1 NUMB is a negative regulator of Hh signaling that acts by promoting the ITCH-dependent ubiquitination of GLI1. ITCH is an E3 ligase that is kept in an inactive conformation by an intramolecular interaction between the HECT domain and a WW motif. Binding of the adaptor protein NUMB to the WW region of ITCH displaces the HECT domain and promotes the catalytic activity of the E3 ligase (di Marcotullio et al, 2006; 2011). 20818436 Pubmed 2011 Numb activates the E3 ligase Itch to control Gli1 function through a novel degradation signal Di Marcotullio, L Greco, A MazzĂ , D Canettieri, G Pietrosanti, L Infante, P Coni, S Moretti, M De Smaele, E Ferretti, E Screpanti, I Gulino, A Oncogene 30:65-76 17115028 Pubmed 2006 Numb is a suppressor of Hedgehog signalling and targets Gli1 for Itch-dependent ubiquitination Di Marcotullio, L Ferretti, Elisabetta Greco, Azzura De Smaele, Enrico Po, Agnese Sico, Maria Anna Alimandi, M Giannini, Giuseppe Maroder, Marella Screpanti, I Gulino, Alberto Nat. Cell Biol. 8:1415-23 inferred by electronic annotation IEA GO IEA