BioPAX pathway converted from "Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol" in the Reactome database.Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosolUb-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosolGlycoproteins with major folding defects are sent to degradation by OS9:SEL1:SYVN1 dimer:DERL2This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>Reactome DB_ID: 106416281endoplasmic reticulum quality control compartmentGO0044322Ub-unfolded protein:(GlcNAc)2 (Man)9-5 [endoplasmic reticulum quality control compartment]Ub-unfolded protein:(GlcNAc)2 (Man)9-5Reactome DB_ID: 106416261Ghost homologue of unfolded protein:(GlcNAc)2 (Man)9-5 [endoplasmic reticulum quality control compartment]Ghost homologue of unfolded protein:(GlcNAc)2 (Man)9-5Reactomehttp://www.reactome.orgReactome DB_ID: 106303401cytosolGO0005829UniProt:P0CG72ubi4Schizosaccharomyces pombeNCBI Taxonomy4896UniProtP0CG72Chain Coordinates1EQUAL76EQUALReactome Database ID Release 7610641628Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10641628ReactomeR-SPO-88672871Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-8867287.1Reactome DB_ID: 106416301Ub-unfolded protein:(GlcNAc)2 (Man)9-5 [cytosol]Ub-unfolded protein:(GlcNAc)2 (Man)9-5Converted from EntitySet in ReactomeReactome DB_ID: 88528511unfolded protein:(GlcNAc)2 (Man)9-5 [cytosol]Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntityReactome DB_ID: 1063034011EQUAL76EQUALReactome Database ID Release 7610641630Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10641630ReactomeR-SPO-88668941Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-8866894.1Reactome Database ID Release 7610641632Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10641632ReactomeR-SPO-10221271Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-1022127.1Proteins with major folding defects are extracted from futile folding cycles in the calnexin chaperone system and the ER Quality Control Compartment, and are translocated back to the cytosol for ER-associated degradation (ERAD). The N-glycan is used as a signal to distinguish proteins to be degraded, by direct binding to a ubiquitin ligase complex composed of, minimally, an E3 ubiquitin-protein ligase, protein sel-1 homolog 1 (SEL1L), derlin-2 (DERL2) and protein OS-9 (OS9) (Christianson et al. 2008, Bernasconi et al. 2008, Alcock & Swanton 2009; review Olzmann et al. 2013). The mechanism of translocation is unknown.18417469Pubmed2008A dual task for the Xbp1-responsive OS-9 variants in the mammalian endoplasmic reticulum: inhibiting secretion of misfolded protein conformers and enhancing their disposalBernasconi, RiccardoPertel, ThomasLuban, JeremyMolinari, MaurizioJ. Biol. Chem. 283:16446-5419084021Pubmed2009Mammalian OS-9 is upregulated in response to endoplasmic reticulum stress and facilitates ubiquitination of misfolded glycoproteinsAlcock, FelicitySwanton, EileithyiaJ. Mol. Biol. 385:1032-4218264092Pubmed2008OS-9 and GRP94 deliver mutant alpha1-antitrypsin to the Hrd1-SEL1L ubiquitin ligase complex for ERADChristianson, John CShaler, Thomas ATyler, Ryan EKopito, Ron RNat. Cell Biol. 10:272-8223232094Pubmed2013The mammalian endoplasmic reticulum-associated degradation systemOlzmann, James AKopito, Ron RChristianson, John CCold Spring Harb Perspect Biol 5:inferred by electronic annotationIEAGOIEA