BioPAX pathway converted from "UCH proteinases" in the Reactome database.UCH proteinasesUCH proteinasesThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>ADRM1 binds 26S proteasomeADRM1 binds 26S proteasomeThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>Reactome DB_ID: 106215091cytosolGO0005829UniProt:Q09289rpn-13Reactomehttp://www.reactome.orgCaenorhabditis elegansNCBI Taxonomy6239UniProtQ09289Chain Coordinates2EQUAL407EQUALReactome DB_ID: 10570893126S proteasome [cytosol]26S proteasomeReactome DB_ID: 105707061UniProt:O44156pas-6UniProtO441561EQUAL263EQUALReactome DB_ID: 105708141Ghost homologue of PSMD10 [cytosol]Ghost homologue of PSMD10Reactome DB_ID: 105707661UniProt:Q9XUV0pbs-5UniProtQ9XUV060EQUAL263EQUALReactome DB_ID: 105707971UniProt:P46502rpt-3UniProtP465021EQUAL418EQUALReactome DB_ID: 105708591UniProt:O61792rpn-8UniProtO617921EQUAL324EQUALReactome DB_ID: 105708851UniProt:Q17971UniProtQ179711EQUAL1843EQUALReactome DB_ID: 105707731UniProt:O62102pbs-2UniProtO6210244EQUAL277EQUALReactome DB_ID: 105708781UniProt:Q95PZ7UniProtQ95PZ72EQUAL254EQUALReactome DB_ID: 105708191UniProt:Q20938rpn-6.1UniProtQ209382EQUAL422EQUALReactome DB_ID: 105707161UniProt:Q09583pas-7UniProtQ095832EQUAL255EQUALReactome DB_ID: 105708641UniProt:Q23449rpn-12UniProtQ234491EQUAL350EQUALReactome DB_ID: 105708441UniProt:O61742rpn-10UniProtO617421EQUAL377EQUALReactome DB_ID: 105707211UniProt:Q9N599pas-3UniProtQ9N5991EQUAL261EQUALReactome DB_ID: 105707611UniProt:P90868pbs-7UniProtP9086846EQUAL264EQUALReactome DB_ID: 105707711UniProt:Q966I8pbs-1UniProtQ966I835EQUAL239EQUALReactome DB_ID: 10570777121EQUAL219EQUALReactome DB_ID: 10570889150EQUAL300EQUALReactome DB_ID: 105708391UniProt:Q04908rpn-3UniProtQ049081EQUAL534EQUALReactome DB_ID: 105708801Ghost homologue of PSMF1 [cytosol]Ghost homologue of PSMF1Reactome DB_ID: 105708541UniProt:Q20585rpn-7UniProtQ205851EQUAL389EQUALReactome DB_ID: 105708911Ghost homologue of SHFM1 [cytosol]Ghost homologue of SHFM1Reactome DB_ID: 105707261UniProt:Q95008pas-5UniProtQ950081EQUAL241EQUALReactome DB_ID: 105708241UniProt:Q19324rpn-5UniProtQ193242EQUAL456EQUALReactome DB_ID: 10570775173EQUAL276EQUALReactome DB_ID: 105707011UniProt:O76577rpn-11UniProtO765771EQUAL310EQUALReactome DB_ID: 105707111UniProt:Q27488pas-2UniProtQ274882EQUAL234EQUALReactome DB_ID: 105707411UniProt:P34286pbs-6UniProtP3428629EQUAL241EQUALReactome DB_ID: 105708071UniProt:O17071rpt-4UniProtO170711EQUAL389EQUALReactome DB_ID: 105708691UniProt:Q10920psmd-9UniProtQ109201EQUAL223EQUALReactome DB_ID: 105707871UniProt:Q18787rpt-1UniProtQ187872EQUAL433EQUALReactome DB_ID: 105708021UniProt:Q9XTT9rpt-6UniProtQ9XTT92EQUAL406EQUALReactome DB_ID: 105708291UniProt:Q22253rpn-9UniProtQ222531EQUAL376EQUALReactome DB_ID: 1057087411EQUAL249EQUALReactome DB_ID: 105708121UniProt:Q18115rpn-2UniProtQ181151EQUAL953EQUALReactome DB_ID: 105707821UniProt:O16368rpt-2UniProtO163682EQUAL440EQUALReactome DB_ID: 105708491UniProt:Q20058UniProtQ200582EQUAL504EQUALReactome DB_ID: 10570746140EQUAL273EQUALReactome DB_ID: 105707561UniProt:Q23237pbs-3UniProtQ232372EQUAL205EQUALReactome DB_ID: 105708871UniProt:Q95005pas-4UniProtQ950051EQUAL256EQUALReactome DB_ID: 1057073611EQUAL248EQUALReactome DB_ID: 1057087612EQUAL239EQUALReactome DB_ID: 105707511UniProt:P91477pbs-4UniProtP914771EQUAL201EQUALReactome DB_ID: 105707921UniProt:O76371rpt-5UniProtO763711EQUAL439EQUALReactome DB_ID: 105708341UniProt:Q9GZH5rpn-1UniProtQ9GZH51EQUAL908EQUALReactome DB_ID: 105707311UniProt:O17586pas-1UniProtO175861EQUAL246EQUALReactome Database ID Release 7510570893Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10570893ReactomeR-CEL-688191Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-68819.1Reactome DB_ID: 106215111ADRM1:26S proteasome [cytosol]ADRM1:26S proteasomeReactome DB_ID: 1062150912EQUAL407EQUALReactome DB_ID: 105708931Reactome Database ID Release 7510621511Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10621511ReactomeR-CEL-56658581Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-5665858.1Reactome Database ID Release 7510621538Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10621538ReactomeR-CEL-56658711Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-5665871.1ADRM1 (also called Rpn13) interacts with the 26S proteasome base unit PRDM1 (Rpn2) via its amino-terminus and is found in the majority of 26S proteasomes. It is a receptor for Ubiquitin (Ub) that can bind K48-linked di-Ub (Schreiner et al. 2008, Husnjak et al. 2008) and de-ubiquitinating enzymes (DUBs) such as PSMD14 (Rpn11, POH1), USP14, and UCHL5 (UCH37) (Reyes-Turcu et al., 2009). Together, these DUBs disassemble poly-Ub chains and recycle ubiquitin during proteasomal degradation.18497817Pubmed2008Proteasome subunit Rpn13 is a novel ubiquitin receptorHusnjak, KoraljkaElsasser, SuzanneZhang, NaixiaChen, XiangRandles, LeahShi, YuanHofmann, KayWalters, Kylie JFinley, DanielDikic, IvanNature 453:481-818497827Pubmed2008Ubiquitin docking at the proteasome through a novel pleckstrin-homology domain interactionSchreiner, PatrickChen, XiangHusnjak, KoraljkaRandles, LeahZhang, NaixiaElsasser, SuzanneFinley, DanielDikic, IvanWalters, Kylie JGroll, MichaelNature 453:548-5219489724Pubmed2009Regulation and cellular roles of ubiquitin-specific deubiquitinating enzymesReyes-Turcu, Francisca EVentii, Karen HWilkinson, Keith DAnnu. Rev. Biochem. 78:363-97inferred by electronic annotationIEAGOIEAADRM1:26S proteaseome binds UCHL5ADRM1:26S proteaseome binds UCHL5This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>Reactome DB_ID: 106215041UniProt:Q09444ubh-4UniProtQ094441EQUAL329EQUALReactome DB_ID: 106215111Reactome DB_ID: 106215131ADRM1:26S proteasome:UCHL5 [cytosol]ADRM1:26S proteasome:UCHL5Reactome DB_ID: 1062150411EQUAL329EQUALReactome DB_ID: 106215111Reactome Database ID Release 7510621513Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10621513ReactomeR-CEL-56658451Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-5665845.1Reactome Database ID Release 7510621515Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10621515ReactomeR-CEL-56658541Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-5665854.1The C-terminal extension of UCHL5 (UCH37) binds to ADRM1, part of the proteasomal 19S regulatory subunit which is itself a subunit of the 26S proteasome. Binding of UCHL5 enhances its DUB activity (Qiu et al. 2006). UCHL5 forms oligomers in solution that have very low DUB activity. Binding with ADRM1 is 1:1, preventing oligomerization of UCHL5 while making the active site of UCHL5 accessible to Ubiquitin (Jiao et al. 2014). When associated with the proteasome, UCHL5 disassembles poly-Ub chains by hydrolyzing the distal ubiquitin from a chain. This dissassembly of the degradation signal from only the distal end of polyubiquitin chains may selectively rescue poorly ubiquitinated or slowly degraded Ub-protein conjugates from proteolysis (Lam et al. 1997). 16990800Pubmed2006A novel proteasome interacting protein recruits the deubiquitinating enzyme UCH37 to 26S proteasomesHamazaki, JunIemura, SNatsume, TYashiroda, HidekiTanaka, KeijiMurata, ShigeoEMBO J. 25:4524-3617139257Pubmed2006hRpn13/ADRM1/GP110 is a novel proteasome subunit that binds the deubiquitinating enzyme, UCH37Qiu, XBOuyang, Song-YingLi, Chao-JunMiao, ShiyingWang, LinfangGoldberg, Alfred LEMBO J. 25:5742-539034192Pubmed1997Editing of ubiquitin conjugates by an isopeptidase in the 26S proteasomeLam, Y AXu, WDeMartino, G NCohen, R ENature 385:737-4024752541Pubmed2014Mechanism of the Rpn13-induced activation of Uch37Jiao, LianyingOuyang, SongyingShaw, NeilSong, GaojieFeng, YingangNiu, FengfengQiu, WeichengZhu, HongtaoHung, Li-WeiZuo, XiaobingEleonora Shtykova, VZhu, PingDong, Yu-HuiXu, RuxiangLiu, Zhi-JieProtein Cell 5:616-30inferred by electronic annotationIEAGOIEAUCHL1, UCHL3 cleave ubiquitin adductsUCHL1, UCHL3 cleave ubiquitin adductsThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>Reactome DB_ID: 293561water [ChEBI:15377]waterChEBI15377Reactome DB_ID: 106239371UCHL1,UCHL3:Ub-Lys [cytosol]UCHL1,UCHL3:Ub-LysConverted from EntitySet in ReactomeReactome DB_ID: 106239081UCHL1,UCHL3 [cytosol]Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntityubh-2 [cytosol]ubh-1 [cytosol]ubh-1 [cytosol]ubh-3 [cytosol]UniProtQ8MNY0UniProtQ9UAV3UniProtQ965V9Reactome DB_ID: 106239111UniProt:P0CG71ubq-1UniProtP0CG71N6-glycyl-L-lysine at 76 (in Homo sapiens)76EQUALN6-glycyl-L-lysine1EQUAL76EQUALReactome Database ID Release 7510623937Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10623937ReactomeR-CEL-67826331Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-6782633.1Reactome DB_ID: 106239391UCHL1,UCHL3:Ub [cytosol]UCHL1,UCHL3:UbConverted from EntitySet in ReactomeReactome DB_ID: 106239081Reactome DB_ID: 1057068011EQUAL76EQUALReactome Database ID Release 7510623939Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10623939ReactomeR-CEL-67825921Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-6782592.1Reactome DB_ID: 11318711cytoplasmGO0005737L-lysinium(1+) [ChEBI:32551]L-lysinium(1+)L-lysine monocationInChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1C6H15N2O2L-lysine[NH3+]CCCC[C@H]([NH3+])C([O-])=OL-lysiniumKDXKERNSBIXSRK-YFKPBYRVSA-O147.19558(2S)-2,6-diammoniohexanoateChEBI32551PHYSIOL-LEFT-TO-RIGHTACTIVATIONReactome DB_ID: 10623937GO0004843GO molecular functionReactome Database ID Release 7510623940Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10623940Reactome Database ID Release 7510623942Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10623942ReactomeR-CEL-56903191Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-5690319.1UCHL1 and UCHL3 can hydrolyze several short C-terminal ubiquitin adducts to generate ubiquitin monomers (Wilkinson et al. 1989, Wada et al. 1998, Larsen et al. 1998). This liberates small molecule nucleophiles that may have inadvertently reacted with Ub C-terminal thiolesters. Because these enzymes can cleave small peptides from the C-terminus of Ub, they could also function in recycling Ub from incomplete proteasomal or lysosomal protein degradation. UCHL3, but not UCHL1, is able to cleave the C-terminus of Neural precursor cell expressed developmentally downregulated protein 8 (NEDD8), a ubiquitin-like protein that activates the largest ubiquitin E3 ligase family, the cullin-RING ligases (Wada et al. 1998, Enchev et al. 2015). UCHL1 and 3 are specifically expressed in neurons, cells of the diffuse neuroendocrine system and their tumors. A polymorphism (S18Y) in UCHL1 is associated with a reduced risk for Parkinson's disease (Wang et al. 2002) and its overexpression is protective in models of Alzheimer's disease (Gong et al. 2006). UCHL1 has been shown to interact with alpha-synuclein, but as a ubiquitin ligase rather than as a ubiquitin hydrolase (Liu et al. 2002). It is K63-polyubiquitinated by Parkin in cooperation with the Ubc13/Uev1a E2 ubiquitin-conjugating enzyme complex, promoting UCH-L1 degradation by the autophagy-lysosome pathway (McKeon et al. 2015).25403879Pubmed2015Parkin-mediated K63-polyubiquitination targets ubiquitin C-terminal hydrolase L1 for degradation by the autophagy-lysosome systemMcKeon, Jeanne ESha, DiLi, LianChin, Lih-ShenCell. Mol. Life Sci. 72:1811-2416923396Pubmed2006Ubiquitin hydrolase Uch-L1 rescues beta-amyloid-induced decreases in synaptic function and contextual memoryGong, BingCao, ZixuanZheng, PingVitolo, Ottavio VLiu, ShuminStaniszewski, AgnieszkaMoolman, DonnaZhang, HongShelanski, MichaelArancio, OttavioCell 126:775-8825531226Pubmed2015Protein neddylation: beyond cullin-RING ligasesEnchev, Radoslav ISchulman, Brenda APeter, MatthiasNat. Rev. Mol. Cell Biol. 16:30-442530630Pubmed1989The neuron-specific protein PGP 9.5 is a ubiquitin carboxyl-terminal hydrolaseWilkinson, K DLee, K MDeshpande, SDuerksen-Hughes, PBoss, J MPohl, JScience 246:670-39790970Pubmed1998Cleavage of the C-terminus of NEDD8 by UCH-L3Wada, HKito, KCaskey, L SYeh, E TKamitani, TBiochem. Biophys. Res. Commun. 251:688-9212210873Pubmed2002ACT and UCH-L1 polymorphisms in Parkinson's disease and age of onsetWang, JianZhao, Chun-YingSi, Yan-MeiLiu, Zhuo-LinChen, BiaoYu, LongMov. Disord. 17:767-719521656Pubmed1998Substrate specificity of deubiquitinating enzymes: ubiquitin C-terminal hydrolasesLarsen, C NKrantz, B AWilkinson, K DBiochemistry 37:3358-6812408865Pubmed2002The UCH-L1 gene encodes two opposing enzymatic activities that affect alpha-synuclein degradation and Parkinson's disease susceptibilityLiu, YichinFallon, LaraLashuel, Hilal ALiu, ZhihuaLansbury, Peter TCell 111:209-18inferred by electronic annotationIEAGOIEAUCHL3, SENP8 cleave NEDD8UCHL3, SENP8 cleave NEDD8This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>Reactome DB_ID: 106239861UCHL3,SENP8:NEDD8(1-88) [cytosol]UCHL3,SENP8:NEDD8(1-88)Converted from EntitySet in ReactomeReactome DB_ID: 106239791UCHL3,SENP8 [cytosol]Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntityubh-1 [cytosol]ulp-3 [cytosol]UniProtQ86FN3Reactome DB_ID: 106239841UniProt:Q93725ned-8UniProtQ937251EQUAL88EQUALReactome Database ID Release 7510623986Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10623986ReactomeR-CEL-67826351Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-6782635.1Reactome DB_ID: 293561Reactome DB_ID: 106239901UCHL3,SENP8:NEDD8 [cytosol]UCHL3,SENP8:NEDD8Converted from EntitySet in ReactomeReactome DB_ID: 106239791Reactome DB_ID: 1062398811EQUAL76EQUALReactome Database ID Release 7510623990Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10623990ReactomeR-CEL-67826431Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-6782643.1Reactome DB_ID: 10623992177EQUAL88EQUALPHYSIOL-LEFT-TO-RIGHTACTIVATIONReactome DB_ID: 10623986GO0019784GO molecular functionReactome Database ID Release 7510623993Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10623993Reactome Database ID Release 7510623995Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10623995ReactomeR-CEL-56908081Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-5690808.1UCHL3 and SENP8 (DEN1) remove the C-terminal extension of NEDD8 propeptides, exposing a C-terminal Gly residue. UCHL3 can also process ubiquitin (Wada et al. 1998). UCHL3 and SENP8 are probably functionally redundant in NEDD8 processing as deletion of either enzyme does not lead to neddylation defects (Chan et al. 2008, Kurihara et al. 2000).18782863Pubmed2008DEN1 deneddylates non-cullin proteins in vivoChan, YaruYoon, JeongsookWu, June-TaiKim, Hyung-JunPan, Kuan-TingYim, JeongbinChien, Cheng-TingJ. Cell. Sci. 121:3218-2310713173Pubmed2000Expression and functional analysis of Uch-L3 during mouse developmentKurihara, L JSemenova, ELevorse, J MTilghman, S MMol. Cell. Biol. 20:2498-504inferred by electronic annotationIEAGOIEAReactome Database ID Release 7510643468Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10643468ReactomeR-CEL-56896031Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-5689603.1DUBs of the Ub C-terminal Hydrolase (UCH) family are thiol proteases that have an N-terminal catalytic domain sometimes followed by C-terminal extensions that mediate protein-protein interactions. Humans have four UCH DUBs (UCH-L1, UCH-L3, UCH37/UCH-L5, and BAP1) that can be divided into the smaller UCH DUBs (UCH-L1 and UCH-L3), which cleave small leaving groups from the C-terminus of ubiquitin (Larsen et al. 1998), and the larger UCH DUBs (UCH37 and BAP1), which can disassemble poly-Ub chains (Misaghi et al. 2009, Lam et al. 1997).19188440Pubmed2009Association of C-terminal ubiquitin hydrolase BRCA1-associated protein 1 with cell cycle regulator host cell factor 1Misaghi, ShahramOttosen, SørenIzrael-Tomasevic, AnitaArnott, DavidLamkanfi, MohamedLee, JamesLiu, JinfengO'Rourke, KarenDixit, Vishva MWilson, Angus CMol. Cell. Biol. 29:2181-9219243136Pubmed2009Polyubiquitin binding and disassembly by deubiquitinating enzymesReyes-Turcu, Francisca EWilkinson, Keith DChem. Rev. 109:1495-50816325574Pubmed2005A genomic and functional inventory of deubiquitinating enzymesNijman, Sebastian M BLuna-Vargas, Mark P AVelds, ArnoBrummelkamp, Thijn RDirac, Annette M GSixma, Titia KBernards, RCell 123:773-86inferred by electronic annotationIEAGOIEA