BioPAX pathway converted from "ROCK1,2 bind ROCKi" in the Reactome database. ROCK1,2 bind ROCKi ROCK1,2 bind ROCKi This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Converted from EntitySet in Reactome Reactome DB_ID: 10595672 1 cytosol GO 0005829 ROCK1,ROCK2 [cytosol] Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntity ROCK2 [cytosol] ROCK1 [cytosol] Reactome http://www.reactome.org Gallus gallus NCBI Taxonomy 9031 UniProt A0A3Q2TTH6 UniProt A0A1D5PK41 Converted from EntitySet in Reactome Reactome DB_ID: 9686558 1 ROCKi [cytosol] Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntity netarsudil [cytosol] ripasudil [cytosol] Guide to Pharmacology 9322 Guide to Pharmacology 10423 Reactome DB_ID: 10595676 1 ROCK1,ROCK2:ROCKi [cytosol] ROCK1,ROCK2:ROCKi Converted from EntitySet in Reactome Reactome DB_ID: 10595672 1 Converted from EntitySet in Reactome Reactome DB_ID: 9686558 1 Reactome Database ID Release 82 10595676 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10595676 Reactome R-GGA-9680444 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-9680444.1 Reactome Database ID Release 82 10656725 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10656725 Reactome R-GGA-9680443 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-9680443.1 Ripasudil (Glanatec), as its hydrochloride hydrate (K-115), is a specifc Rho-associated coiled-coil containing protein kinase (ROCK) inhibitor (ROCKi) used for the treatment of glaucoma and ocular hypertension in Japan (Garnock-Jones 2014). Netarsudil is a USA-approved ROCKi used to treat glaucoma and ocular hypertenstion (Sturdivant et al. 2016, Tanna & Johnson 2018). 25414122 Pubmed 2014 Ripasudil: first global approval Garnock-Jones, Karly P Drugs 74:2211-5 27072905 Pubmed 2016 Discovery of the ROCK inhibitor netarsudil for the treatment of open-angle glaucoma Sturdivant, Jill M Royalty, Susan M Lin, Cheng-Wen Moore, Lori A Yingling, Jeffrey D Laethem, Carmen L Sherman, Bryan Heintzelman, Geoffrey R Kopczynski, Casey C deLong, Mitchell A Bioorg. Med. Chem. Lett. 26:2475-2480 30007591 Pubmed 2018 Rho Kinase Inhibitors as a Novel Treatment for Glaucoma and Ocular Hypertension Tanna, Angelo P Johnson, Mark Ophthalmology 125:1741-1756 inferred by electronic annotation IEA GO IEA