BioPAX pathway converted from "SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion" in the Reactome database. SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Sema3A binds Nrp-1 bound to PlexinA Sema3A binds Nrp-1 bound to PlexinA This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Reactome DB_ID: 10594921 1 plasma membrane GO 0005886 NRP1:PlexinA1-4:FARP2:FYN [plasma membrane] NRP1:PlexinA1-4:FARP2:FYN Reactome DB_ID: 10594919 1 Plexin-A1-4:FYN:FARP2 [plasma membrane] Plexin-A1-4:FYN:FARP2 Reactome DB_ID: 10594917 1 cytosol GO 0005829 UniProt:E1C5B7 FARP2 Reactome http://www.reactome.org Gallus gallus NCBI Taxonomy 9031 UniProt E1C5B7 Chain Coordinates 1 EQUAL 1054 EQUAL Reactome DB_ID: 10594913 1 Plexin-A1-4:FYN [plasma membrane] Plexin-A1-4:FYN Reactome DB_ID: 10588434 1 UniProt:A0A3Q2U639 UniProt A0A3Q2U639 2 EQUAL 537 EQUAL Converted from EntitySet in Reactome Reactome DB_ID: 10594911 1 Plexin-A1-4 [plasma membrane] Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntity PLXNA4 [plasma membrane] PLXNA1 [plasma membrane] PLXNA2 [plasma membrane] UniProt F1NZB0 UniProt A0A3Q2U4H8 UniProt F1NYZ6 Reactome Database ID Release 82 10594913 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10594913 Reactome R-GGA-399844 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-399844.1 Reactome Database ID Release 82 10594919 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10594919 Reactome R-GGA-421116 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-421116.1 Reactome DB_ID: 10585055 1 UniProt:A0A1L1RW02 UniProt A0A1L1RW02 22 EQUAL 923 EQUAL Reactome Database ID Release 82 10594921 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10594921 Reactome R-GGA-399837 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-399837.1 Reactome DB_ID: 10594874 1 extracellular region GO 0005576 Sema3A dimer [extracellular region] Sema3A dimer Reactome DB_ID: 10594872 2 UniProt:R4GJE6 SEMA3A UniProt R4GJE6 21 EQUAL 771 EQUAL Reactome Database ID Release 82 10594874 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10594874 Reactome R-GGA-399861 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-399861.1 Reactome DB_ID: 10594917 1 1 EQUAL 1054 EQUAL Reactome DB_ID: 10594925 1 Sema3A:Nrp-1:Plexin A:Fyn [plasma membrane] Sema3A:Nrp-1:Plexin A:Fyn Reactome DB_ID: 10594874 1 Reactome DB_ID: 10594923 1 NRP1:Plexin-A1-4:FYN [plasma membrane] NRP1:Plexin-A1-4:FYN Reactome DB_ID: 10588434 1 2 EQUAL 537 EQUAL Reactome DB_ID: 10585055 1 22 EQUAL 923 EQUAL Converted from EntitySet in Reactome Reactome DB_ID: 10594911 1 Reactome Database ID Release 82 10594923 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10594923 Reactome R-GGA-399841 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-399841.1 Reactome Database ID Release 82 10594925 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10594925 Reactome R-GGA-399858 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-399858.1 Reactome Database ID Release 82 10594927 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10594927 Reactome R-GGA-399933 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-399933.1 Although neuropilin-1 is required for Sema-3A action, it is incapable of transmitting a Sema-3A signal to the growth cone interior. The function of Sema-3A is mediated by Plexins. Sema-3A binds with high affinity to Plexin when the latter is complexed with Neuropilin-1. <br>Plexin-A1 is known to act as an R-Ras GAP (GTPase activating protein) when bound by Sema-3A. Plexin's GAP activity is regulated by FARP2 mediated Rac1 activation. Sema-3A binding to neuropilin-1/Plexin-A1 seems to induce a conformational change of plexin-A1 necessary for releasing FARP2. This suggests that neuropilin1 is required not only for ligand binding, but also for signaling, by modulating the interaction of FARP2 with plexin-A1. 16286926 Pubmed 2005 FARP2 triggers signals for Sema3A-mediated axonal repulsion Toyofuku, T Yoshida, J Sugimoto, T Zhang, H Kumanogoh, Atsushi Hori, M Kikutani, Hitoshi Nat Neurosci 8:1712-9 10679438 Pubmed 2000 Semaphorins and their receptors in vertebrates and invertebrates Raper, JA Curr Opin Neurobiol 10:88-94 inferred by electronic annotation IEA GO IEA Inhibition of integrin activation by sequestering PIP5KIgamma Inhibition of integrin activation by sequestering PIP5KIgamma This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Reactome DB_ID: 10594933 1 PIP5K1gamma:Talin-1 [cytosol] PIP5K1gamma:Talin-1 Reactome DB_ID: 10590482 1 UniProt:A0A1D5PTR5 TLN1 UniProt A0A1D5PTR5 1 EQUAL 2541 EQUAL Reactome DB_ID: 10594931 1 UniProt:F1ND21 PIP5K1C UniProt F1ND21 1 EQUAL 668 EQUAL Reactome Database ID Release 82 10594933 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10594933 Reactome R-GGA-398218 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-398218.1 Reactome DB_ID: 10594917 1 1 EQUAL 1054 EQUAL Reactome DB_ID: 10594935 1 FARP2:PIP5KIgamma [cytosol] FARP2:PIP5KIgamma Reactome DB_ID: 10594917 1 1 EQUAL 1054 EQUAL Reactome DB_ID: 10594931 1 1 EQUAL 668 EQUAL Reactome Database ID Release 82 10594935 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10594935 Reactome R-GGA-399839 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-399839.1 Reactome DB_ID: 10590482 1 1 EQUAL 2541 EQUAL Reactome Database ID Release 82 10594937 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10594937 Reactome R-GGA-399936 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-399936.1 Sema3A also mediates integrin inhibition by a mechanism involving PIPKI gamma 661, a phosphatidylinositol kinase that participates in integrin mediated focal adhesion assembly. The binding of talin to beta-integrin is required for integrin activation and is strengthened by PtdIns(4,5)P(2). PIPKI gamma 661, an enzyme that makes PtdIns(4,5)P(2), is targeted to focal adhesions by an association with talin. Sema3A induced dissociation of FARP2 from Plexin-A1 stimulates an interaction between FARP2 and PIPKI gamma 661. FARP2 inhibits PIPK gamma 661's kinase activity, and thus inhibits integrin mediated adhesion. 12422220 Pubmed 2002 Type I gamma phosphatidylinositol phosphate kinase targets and regulates focal adhesions Ling, K Doughman, RL Firestone, AJ Bunce, MW Anderson, RA Nature 420:89-93 16930978 Pubmed 2006 Repulsion or adhesion: receptors make the call Halloran, MC Wolman, MA Curr Opin Cell Biol 18:533-40 10934324 Pubmed 2000 Molecular basis of semaphorin-mediated axon guidance Nakamura, F Kalb, RG Strittmatter, SM J Neurobiol 44:219-29 inferred by electronic annotation IEA GO IEA Reactome Database ID Release 82 10660708 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10660708 Reactome R-GGA-399955 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-399955.1 Sema3A, a prototypical semaphorin, acts as a chemorepellent or a chemoattractant for axons by activating a receptor complex comprising neuropilin-1 as the ligand-binding subunit and plexin-A1 as the signal-transducing subunit. Sema3A inhibits cell migration by inhibiting integrin ligand-binding activity. 18580951 Pubmed 2008 The semaphorins: versatile regulators of tumour progression and tumour angiogenesis Neufeld, G Kessler, O Nat Rev Cancer 8:632-45 18374575 Pubmed 2008 Semaphorin signaling: progress made and promises ahead Zhou, Y Gunput, RA Pasterkamp, RJ Trends Biochem Sci 33:161-70 inferred by electronic annotation IEA GO IEA