BioPAX pathway converted from "NEXT3 is cleaved to produce NICD3" in the Reactome database. 3.4.23.32 3.4.23.43 3.4.23.20 3.4.23.25 3.4.23.36 3.4.23.35 3.4.23.34 3.4.23.4 3.4.23.5 3.4.23.1 3.4.23.15 NEXT3 is cleaved to produce NICD3 NEXT3 is cleaved to produce NICD3 This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Reactome DB_ID: 10661488 1 plasma membrane GO 0005886 UniProt:F1NZ70 Reactome http://www.reactome.org Gallus gallus NCBI Taxonomy 9031 UniProt F1NZ70 Chain Coordinates 1629 EQUAL 2321 EQUAL Reactome DB_ID: 10661507 1 cytosol GO 0005829 1662 EQUAL 2321 EQUAL Reactome DB_ID: 10661509 1 1629 EQUAL 1661 EQUAL PHYSIOL-LEFT-TO-RIGHT ACTIVATION Reactome DB_ID: 10592460 gamma-secretase complex [plasma membrane] gamma-secretase complex Reactome DB_ID: 10592440 1 UniProt:H9KZL2 NCSTN UniProt H9KZL2 34 EQUAL 709 EQUAL Reactome DB_ID: 10592436 1 UniProt:A0A3Q2TV14 APH1A UniProt A0A3Q2TV14 1 EQUAL 265 EQUAL Converted from EntitySet in Reactome Reactome DB_ID: 10592458 1 Presenilin [plasma membrane] Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntity Reactome DB_ID: 10592432 1 Ghost homologue of PSENEN [plasma membrane] Ghost homologue of PSENEN Reactome Database ID Release 83 10592460 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10592460 Reactome R-GGA-157343 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-157343.1 GO 0004190 GO molecular function Reactome Database ID Release 83 10661510 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10661510 Reactome Database ID Release 83 10661512 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10661512 Reactome R-GGA-9013361 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-9013361.1 GO 0035333 GO biological process NEXT3 fragment of NOTCH3 is further cleaved at the S3 site by the gamma-secretase complex, containing either PSEN1 (presenilin-1) or PSEN2 (presenilin-2) as the catalytic subunit, which releases the intracellular domain NICD3 into the cytosol (Groot et al. 2014). 24842903 Pubmed 2014 Regulated proteolysis of NOTCH2 and NOTCH3 receptors by ADAM10 and presenilins Groot, Arjan J Habets, Roger Yahyanejad, Sanaz Hodin, Caroline M Reiss, Karina Saftig, P Theys, Jan Vooijs, M Mol. Cell. Biol. 34:2822-32 inferred by electronic annotation IEA GO IEA