BioPAX pathway converted from "PIAS1 binds p-STAT1 dimer" in the Reactome database.PIAS1 binds p-STAT1 dimerPIAS1 binds p-STAT1 dimerThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>Reactome DB_ID: 106615751nucleoplasmGO0005654IFNG-activated factor (GAF) [nucleoplasm]IFNG-activated factor (GAF)Converted from EntitySet in ReactomeReactome DB_ID: 106615732Homologues of p-S727,Y701-STAT1-1 [nucleoplasm]Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntityphospho-dstD [nucleoplasm]phospho-dstB [nucleoplasm]phospho-dstC [nucleoplasm]phospho-dstA [nucleoplasm]Reactomehttp://www.reactome.orgDictyostelium discoideumNCBI Taxonomy44689UniProtQ86I20UniProtQ70GP4UniProtQ54BD4UniProtO00910Reactome Database ID Release 7510661575Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10661575ReactomeR-DDI-8738241Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-873824.1Reactome DB_ID: 106615981UniProt:Q8N0B4SUMOUniProtQ8N0B4Chain Coordinates2EQUAL97EQUALReactome DB_ID: 106615931UniProt:Q555X5pisAUniProtQ555X51EQUAL651EQUALReactome DB_ID: 106616001p-STAT1 dimer:PIAS:SUMO1 [nucleoplasm]p-STAT1 dimer:PIAS:SUMO1Reactome DB_ID: 1066159812EQUAL97EQUALReactome DB_ID: 106615751Reactome DB_ID: 1066159311EQUAL651EQUALReactome Database ID Release 7510661600Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10661600ReactomeR-DDI-8772971Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-877297.1Reactome Database ID Release 7510661602Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10661602ReactomeR-DDI-8772811Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-877281.1PIAS1 protein interacts directly with phoshorylated STAT1 dimers and inhibit the transcriptional activity of STAT1 by blocking the DNA-binding domain of STAT1. It has also been suggested that PIAS proteins might regulate transcription by promoting small ubiquitin-related modifier (SUMO1) conjugation of STAT1. The significance of STAT1 sumoylation in regulating STAT1 activity is controversial and needs to be clarified.10805787Pubmed2000Distinct roles of the NH2- and COOH-terminal domains of the protein inhibitor of activated signal transducer and activator of transcription (STAT) 1 (PIAS1) in cytokine-induced PIAS1-Stat1 interactionLiao, JFu, YShuai, KProc Natl Acad Sci U S A 97:5267-7212855578Pubmed2003PIAS proteins promote SUMO-1 conjugation to STAT1Ungureanu, DVanhatupa, SKotaja, NYang, JAittomaki, SJänne, OAPalvimo, JJSilvennoinen, OBlood 102:3311-318031232Pubmed2007PIAS proteins as regulators of small ubiquitin-related modifier (SUMO) modifications and transcriptionPalvimo, JJBiochem Soc Trans 35:1405-8inferred by electronic annotationIEAGOIEA