BioPAX pathway converted from "Activation of Rap1 by membrane-associated GEFs" in the Reactome database.Activation of Rap1 by membrane-associated GEFsActivation of Rap1 by membrane-associated GEFsThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>Reactome DB_ID: 294381cytosolGO0005829GTP [ChEBI:15996]GTPGuanosine 5'-triphosphateReactomehttp://www.reactome.orgChEBI15996Reactome DB_ID: 106571791plasma membraneGO0005886RAP1:GDP [plasma membrane]RAP1:GDPConverted from EntitySet in ReactomeReactome DB_ID: 106571751RAP1 [plasma membrane]Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntityrapC [plasma membrane]rapB [plasma membrane]rapA [plasma membrane]RAP1A [plasma membrane]Dictyostelium discoideumNCBI Taxonomy44689UniProtQ55BW0UniProtQ86L51UniProtP18613UniProtQ54BC3Reactome DB_ID: 294201GDP [ChEBI:17552]GDPGuanosine 5'-diphosphateGuanosine diphosphateChEBI17552Reactome Database ID Release 7510657179Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10657179ReactomeR-DDI-3540741Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-354074.1Reactome DB_ID: 294201Reactome DB_ID: 106571771RAP1:GTP [plasma membrane]RAP1:GTPConverted from EntitySet in ReactomeReactome DB_ID: 106571751Reactome DB_ID: 294381Reactome Database ID Release 7510657177Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10657177ReactomeR-DDI-3541261Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-354126.1PHYSIOL-LEFT-TO-RIGHTACTIVATIONConverted from EntitySet in ReactomeReactome DB_ID: 10658403Rap1 cAMP-GEFs [plasma membrane]Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntitygefF [plasma membrane]gbpD [plasma membrane]gefV [plasma membrane]gefH [plasma membrane]gefP [plasma membrane]gefP [plasma membrane]gefR [plasma membrane]gefJ [plasma membrane]RAPGEF3 [plasma membrane]gefI [plasma membrane]gefA [plasma membrane]UniProtQ54C94UniProtQ54S40UniProtQ55FD8UniProtQ8IS16UniProtQ54TK8UniProtQ8SSQ0UniProtQ8IS14UniProtQ54H95UniProtQ8IS15UniProtQ54PQ4GO0005085GO molecular functionReactome Database ID Release 7510662598Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10662598Reactome Database ID Release 7510662600Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10662600ReactomeR-DDI-9392651Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-939265.1Signals from agonist receptors (such as GPVI) trigger the production of PIP3, DAG, cAMP and elevated Ca++ levels. This leads to the activation and translocation of active Rap1-GTP to the plasma membrane. Rap-GEFs stimulate the replacement of GDP for GTP, activating Rap1. Several Rap1 GEFs have been identified enabling Rap1 to respond to diverse stimuli. CalDAG-GEFs activate Rap1 in response to calcium and DAG, downstream of Phospholipase C. EPAC (exchange proteins directly activated by cAMP) GEFs are activated by binding cAMP.12585966Pubmed2003Bidirectional integrin alphaIIbbeta3 signalling regulating platelet adhesion under flow: contribution of protein kinase CGiuliano, SNesbitt, WSRooney, MJackson, SPBiochem J 372:163-7215469846Pubmed2004RIAM, an Ena/VASP and Profilin ligand, interacts with Rap1-GTP and mediates Rap1-induced adhesionLafuente, EMvan Puijenbroek, AAKrause, MCarman, CVFreeman, GJBerezovskaya, AConstantine, ESpringer, TAGertler, FBBoussiotis, VADev Cell 7:585-9516757337Pubmed2006Rap1 regulation of RIAM and cell adhesionLafuente, EBoussiotis, VAMethods Enzymol 407:345-5815334074Pubmed2004CalDAG-GEFI integrates signaling for platelet aggregation and thrombus formationCrittenden, JRBergmeier, WZhang, YPiffath, CLLiang, YWagner, DDHousman, DEGraybiel, AMNat Med 10:982-616076873Pubmed2005Multiple roles of Rap1 in hematopoietic cells: complementary versus antagonistic functionsStork, PJDillon, TJBlood 106:2952-61inferred by electronic annotationIEAGOIEA