BioPAX pathway converted from "KDM6B demethylates H3K27me3 on p16INK4A promoter" in the Reactome database.

1.14.11.68

KDM6B demethylates H3K27me3 on p16INK4A promoter

This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>

Reactome DB_ID: 113671

nucleoplasmGO0005654

2-oxoglutarate(2-) [ChEBI:16810]

2-oxoglutarate(2-)

2-ketoglutaratealpha-ketoglutarate2-oxopentanedioic acid, ion(2-)2-oxoglutarate

Reactomehttp://www.reactome.orgChEBI16810

Reactome DB_ID: 10673052

CDKN2A Gene:H3K27Me3-Nucleosome [nucleoplasm]

CDKN2A Gene:H3K27Me3-Nucleosome

Reactome DB_ID: 10673037

Ghost homologue of CDKN2A gene [nucleoplasm]

Ghost homologue of CDKN2A gene

Reactome DB_ID: 10673050

Nucleosome with H3K27me3 [nucleoplasm]

Nucleosome with H3K27me3

Converted from EntitySet in Reactome

Reactome DB_ID: 10649184

Histone H2A [nucleoplasm]Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntity

Reactome DB_ID: 10649113

UniProt:Q76NW2H4b

Dictyostelium discoideum

NCBI Taxonomy44689UniProtQ76NW2

Chain Coordinates

EQUAL

103

EQUAL

Converted from EntitySet in Reactome

Reactome DB_ID: 10673048

Histone H3 (H3K27me3) [nucleoplasm]Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntityH3v1 [nucleoplasm]H3a [nucleoplasm]H3b [nucleoplasm]

UniProtQ54F38UniProtO15819UniProtQ55BN9Converted from EntitySet in Reactome

Reactome DB_ID: 10649211

Histone H2B [nucleoplasm]Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntity

Reactome Database ID Release 7510673050Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10673050ReactomeR-DDI-433757

Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-433757.1Reactome Database ID Release 7510673052Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10673052ReactomeR-DDI-3222570

Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-3222570.1

Reactome DB_ID: 10673054

CDKN2A Gene:Nucleosome [nucleoplasm]

CDKN2A Gene:Nucleosome

Reactome DB_ID: 10673037

Reactome DB_ID: 10656786

Nucleosome [nucleoplasm]

Nucleosome

Converted from EntitySet in Reactome

Reactome DB_ID: 10649184

Reactome DB_ID: 10649113

EQUAL

103

EQUAL

Converted from EntitySet in Reactome

Reactome DB_ID: 10649211

Converted from EntitySet in Reactome

Reactome DB_ID: 10656784

Histone H3 [nucleoplasm]Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntityH3v1 [nucleoplasm]H3b [nucleoplasm]H3a [nucleoplasm]

Reactome Database ID Release 7510656786Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10656786ReactomeR-DDI-427402

Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-427402.1Reactome Database ID Release 7510673054Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10673054ReactomeR-DDI-3222592

Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-3222592.1

Reactome DB_ID: 159939

succinate(2-) [ChEBI:30031]

succinate(2-)

succinate(-)OOC-CH2-CH2-COO(-)butanedioic acid, ion(2-)butanedioate

ChEBI30031PHYSIOL-LEFT-TO-RIGHT

ACTIVATION

Reactome DB_ID: 10673061

KDM6B:Fe2+ [nucleoplasm]

KDM6B:Fe2+

Reactome DB_ID: 111793

iron(2+) [ChEBI:29033]

iron(2+)

FE (II) IONFe(2+)Fe(II)Ferrous ionFe2+iron ion(2+)

ChEBI29033

Reactome DB_ID: 10673059

UniProt:O77033trfA

UniProtO77033

EQUAL

1643

EQUAL

Reactome Database ID Release 7510673061Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10673061ReactomeR-DDI-3222589

Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-3222589.1GO0071558

GO molecular function

Reactome Database ID Release 7510673062Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10673062Reactome Database ID Release 7510673064Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10673064ReactomeR-DDI-3222593

Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-3222593.1Histone demethylase KDM6B (JMJD3) demethylates H3K27Me3 marks i.e. removes methyl groups from lysine 28 of histone HIST1H3A on CDKN2A locus, thereby activating CDKN2A transcription. In human cells, H3K27Me3 marks are predominantly found around the first exon of p16INK4A, and KDM6B therefore activates p16INK4A transcription but not p14ARF transcription. In mouse cells, H3K27Me3 marks are found throughout the Cdkn2a locus and Kdm6b demethylase activity induces transcription of both p16Ink4a and p19Arf. KDM6B action promotes both the oncogene-induced and oxidative stress-induced senescence (Agger et al. 2009, Barradas et al. 2009).

19451218Pubmed2009Histone demethylase JMJD3 contributes to epigenetic control of INK4a/ARF by oncogenic RASBarradas, MartaAnderton, EmmaAcosta, Juan CarlosLi, SideBanito, AnaRodriguez-Niedenführ, MarcMaertens, GoedeleBanck, MichaelaZhou, Ming-MingWalsh, Martin JPeters, GordonGil, JesúsGenes Dev. 23:1177-8219451217Pubmed2009The H3K27me3 demethylase JMJD3 contributes to the activation of the INK4A-ARF locus in response to oncogene- and stress-induced senescenceAgger, KarlCloos, Paul A CRudkjaer, LiseWilliams, KristineAndersen, GitteChristensen, JesperHelin, KristianGenes Dev. 23:1171-6inferred by electronic annotationIEAGOIEA