BioPAX pathway converted from "RNA Polymerase I Promoter Clearance" in the Reactome database.RNA Polymerase I Promoter ClearanceRNA Polymerase I Promoter ClearanceThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>RNA Polymerase I Transcription InitiationRNA Polymerase I Transcription InitiationThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>Binding of RRN3 to RNA Polymerase IBinding of RRN3 to RNA Polymerase IThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>Reactome DB_ID: 106484351nucleoplasmGO0005654RNA Polymerase I Holoenzyme [nucleoplasm]RNA Polymerase I HoloenzymeReactome DB_ID: 106484041UniProt:Q54BM1polr1bReactomehttp://www.reactome.orgDictyostelium discoideumNCBI Taxonomy44689UniProtQ54BM1Chain Coordinates1EQUAL1135EQUALReactome DB_ID: 106467701UniProt:Q55AB6polr2lUniProtQ55AB61EQUAL67EQUALReactome DB_ID: 106467601UniProt:Q54EH2polr2eUniProtQ54EH21EQUAL210EQUALReactome DB_ID: 106484231UniProt:Q54FE8polr1eUniProtQ54FE81EQUAL481EQUALReactome DB_ID: 106484181Ghost homologue of CD3EAP [nucleoplasm]Ghost homologue of CD3EAPReactome DB_ID: 106467651UniProt:Q54FA8polr2fUniProtQ54FA82EQUAL127EQUALReactome DB_ID: 106484331UniProt:Q54YF5rpa12UniProtQ54YF51EQUAL126EQUALReactome DB_ID: 106484111UniProt:Q54SN4polr1cUniProtQ54SN42EQUAL346EQUALReactome DB_ID: 106484061Ghost homologue of POLR1D [nucleoplasm]Ghost homologue of POLR1DReactome DB_ID: 106467501UniProt:Q54YW8polr2hUniProtQ54YW82EQUAL150EQUALReactome DB_ID: 106484281UniProt:Q55FA4rpa43UniProtQ55FA41EQUAL338EQUALReactome DB_ID: 106484161UniProt:Q86H36polr1aUniProtQ86H361EQUAL1720EQUALReactome DB_ID: 106467551UniProt:Q54R66polr2kUniProtQ54R661EQUAL58EQUALReactome Database ID Release 7510648435Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10648435ReactomeR-DDI-738591Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-73859.1Reactome DB_ID: 106484401UniProt:Q54HB0UniProtQ54HB01EQUAL651EQUALReactome DB_ID: 106484421Active RNA Polymerase I [nucleoplasm]Active RNA Polymerase IReactome DB_ID: 1064844011EQUAL651EQUALReactome DB_ID: 106484351Reactome Database ID Release 7510648442Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10648442ReactomeR-DDI-737151Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-73715.1Reactome Database ID Release 7510648444Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10648444ReactomeR-DDI-737571Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-73757.1After the assembly of the RNA Polymerase I Holoenzyme, Rrn3 binding occurs (Engel et al. 2016, Pilsl et al. 2016).27418309Pubmed2016RNA polymerase I-Rrn3 complex at 4.8 Å resolutionEngel, ChristophPlitzko, JürgenCramer, PNat Commun 7:1212927418187Pubmed2016Structure of the initiation-competent RNA polymerase I and its implication for transcriptionPilsl, MichaelCrucifix, CorinnePapai, GaborKrupp, FerdinandSteinbauer, RobertGriesenbeck, JoachimMilkereit, PhilippTschochner, HerbertSchultz, PatrickNat Commun 7:12126inferred by electronic annotationIEAGOIEAReactome Database ID Release 7510696849Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10696849ReactomeR-DDI-737621Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-73762.1GO0006361GO biological processDuring initiation the double-stranded DNA must be melted and transcription begins. SL1 forms and interacts with UBF-1 and the rDNA promoter. It is this platform that will recruit active RNA polymerase I to the SL1:phosphorlated UBF-1:rDNA promoter complex.<p>Mammalian rRNA genes are preceded by a terminator element that is recognized by the SL1 complex. This SL1 modulated acetylation of the basal Pol I transcription machinery has functional consequences suggesting that the reversible acetylation may be one way to regulate rDNA transcription.inferred by electronic annotationIEAGOIEARNA Polymerase I Promoter EscapeRNA Polymerase I Promoter EscapeThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>Loss of Rrn3 from RNA Polymerase I promoter escape complexLoss of Rrn3 from RNA Polymerase I promoter escape complexThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>Reactome DB_ID: 106485251RNA Polymerase I Transcription Initiation complex [nucleoplasm]RNA Polymerase I Transcription Initiation complexReactome DB_ID: 106484421Reactome DB_ID: 106485231TFIIH [nucleoplasm]TFIIHReactome DB_ID: 106485011UniProt:Q86IB5gtf2h3UniProtQ86IB51EQUAL308EQUALReactome DB_ID: 106485111UniProt:Q54C29gtf2h4UniProtQ54C291EQUAL462EQUALReactome DB_ID: 106485161UniProt:Q55FP1gtf2h1UniProtQ55FP11EQUAL548EQUALReactome DB_ID: 106485061UniProt:Q86KZ2gtf2h2UniProtQ86KZ21EQUAL395EQUALReactome DB_ID: 106484911UniProt:Q55G81repDUniProtQ55G811EQUAL760EQUALReactome DB_ID: 106485211UniProt:Q55CT8gtf2h5UniProtQ55CT81EQUAL71EQUALReactome DB_ID: 106484861CAK [nucleoplasm]CAKReactome DB_ID: 106484741UniProt:P54685cdk7UniProtP546851EQUAL346EQUALReactome DB_ID: 106484791UniProt:Q55F19cycHUniProtQ55F191EQUAL323EQUALReactome DB_ID: 106484841UniProt:Q54I13mnat1UniProtQ54I131EQUAL309EQUALReactome Database ID Release 7510648486Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10648486ReactomeR-DDI-692211Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-69221.1Reactome DB_ID: 106484961UniProt:O00835repBUniProtO008351EQUAL782EQUALReactome Database ID Release 7510648523Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10648523ReactomeR-DDI-1096341Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-109634.1Reactome DB_ID: 106484691Acetylayed SL1:PhosUBF-1:rDNA promoter [nucleoplasm]Acetylayed SL1:PhosUBF-1:rDNA promoterReactome DB_ID: 106484631Acetylated SL1 [nucleoplasm]Acetylated SL1Reactome DB_ID: 106484521Ghost homologue of TAF1A [nucleoplasm]Ghost homologue of TAF1AReactome DB_ID: 106484611UniProt:P26355tbpAUniProtP263551EQUAL339EQUALReactome DB_ID: 106484561Ghost homologue of TAF1D [nucleoplasm]Ghost homologue of TAF1DReactome DB_ID: 106484501UniProt:Q554V6UniProtQ554V6N6-acetyl-L-lysine at unknown positionN6-acetyl-L-lysine [MOD:00064]1EQUAL588EQUALReactome DB_ID: 106484541Ghost homologue of TAF1C [nucleoplasm]Ghost homologue of TAF1CReactome Database ID Release 7510648463Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10648463ReactomeR-DDI-736931Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-73693.1Reactome DB_ID: 106484671Phosphorylated UBF-1:rDNA promoter [nucleoplasm]Phosphorylated UBF-1:rDNA promoterReactome DB_ID: 736821rDNA Promoter [nucleoplasm]rDNA PromoterReactome DB_ID: 106484651Ghost homologue of p-UBTF [nucleoplasm]Ghost homologue of p-UBTFReactome Database ID Release 7510648467Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10648467ReactomeR-DDI-736851Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-73685.1Reactome Database ID Release 7510648469Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10648469ReactomeR-DDI-736941Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-73694.1Reactome Database ID Release 7510648525Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10648525ReactomeR-DDI-737161Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-73716.1Reactome DB_ID: 106485291RNA Polymerase I promoter escape complex [nucleoplasm]RNA Polymerase I promoter escape complexReactome DB_ID: 106484631Reactome DB_ID: 106485271Ghost homologue of UBTF [nucleoplasm]Ghost homologue of UBTFReactome DB_ID: 106485231Reactome DB_ID: 106484351Reactome Database ID Release 7510648529Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10648529ReactomeR-DDI-737171Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-73717.1Reactome DB_ID: 1064844011EQUAL651EQUALReactome Database ID Release 7510648531Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10648531ReactomeR-DDI-737691Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-73769.1Upon transcription initiation it is thought that RRN3 is inactivated and dissociates from the Loss of Rrn3 from the RNA Polymerase I promoter escape complex. SL1 and UBF are thought to remain bound to the promoter for multiple rounds of transcription initiation12646563Pubmed2003Rrn3 becomes inactivated in the process of ribosomal DNA transcription.Hirschler-Laszkiewicz, ICavanaugh, AHMirza, ALun, MHu, QSmink, TRothblum, LIJ Biol Chem 278:18953-9inferred by electronic annotationIEAGOIEA2.7.7.6Elongation of pre-rRNA transcriptElongation of pre-rRNA transcriptThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>Converted from EntitySet in ReactomeReactome DB_ID: 305951NTP [nucleoplasm]Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntityGTP [nucleoplasm]CTP [nucleoplasm]UTP [nucleoplasm]ATP [nucleoplasm]ChEBI15996ChEBI17677ChEBI15713ChEBI30616Reactome DB_ID: 749851elongating pre-rRNA transcript [nucleoplasm]elongating pre-rRNA transcriptReactome DB_ID: 749851PHYSIOL-LEFT-TO-RIGHTACTIVATIONReactome DB_ID: 10648529GO0003899GO molecular functionReactome Database ID Release 7510649091Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10649091Reactome Database ID Release 7510649239Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10649239ReactomeR-DDI-749861Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-74986.1At the beginning of this reaction, 1 molecule of 'elongating pre-rRNA transcript', and 1 molecule of 'NTP' are present. At the end of this reaction, 1 molecule of 'elongating pre-rRNA transcript' is present.<br><br> This reaction takes place in the 'nucleolus' and is mediated by the 'DNA-directed RNA polymerase activity' of 'RNA Polymerase I promoter escape complex'.<br>14969726Pubmed2004Mechanism of RNA polymerase I transcriptionComai, LucioAdv. Protein Chem. 67:123-55inferred by electronic annotationIEAGOIEAACTIVATIONReactome Database ID Release 7510649240Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10649240Reactome DB_ID: 10649237Chromatin (H3K9me2):CBX3 [nucleoplasm]Chromatin (H3K9me2):CBX3Reactome DB_ID: 106492351Chromatin (H3K9me2) [nucleoplasm]Chromatin (H3K9me2)Reactome DB_ID: 106492331Nucleosome with H3K9me2 [nucleoplasm]Nucleosome with H3K9me2Converted from EntitySet in ReactomeReactome DB_ID: 106491842Histone H2A [nucleoplasm]Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntityConverted from EntitySet in ReactomeReactome DB_ID: 106492312Histone H3 dimethylated at lysine-9 [nucleoplasm]Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntityH3b [nucleoplasm]H3v1 [nucleoplasm]H3a [nucleoplasm]UniProtQ55BN9UniProtQ54F38UniProtO15819Reactome DB_ID: 106491132UniProt:Q76NW2H4bUniProtQ76NW22EQUAL103EQUALConverted from EntitySet in ReactomeReactome DB_ID: 106492112Histone H2B [nucleoplasm]Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntityReactome Database ID Release 7510649233Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10649233ReactomeR-DDI-4273311Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-427331.1Reactome DB_ID: 294281DNA [nucleoplasm]DNADeoxyribonucleic AcidReactome Database ID Release 7510649235Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10649235ReactomeR-DDI-32116831Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-3211683.1Converted from EntitySet in ReactomeReactome DB_ID: 106491081Homologues of CBX3 [nucleoplasm]Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntityhcpC [nucleoplasm]CBX3 [nucleoplasm]CBX3 [nucleoplasm]UniProtQ55C69UniProtQ54RQ4UniProtQ54RN0Reactome Database ID Release 7510649237Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10649237ReactomeR-DDI-4273441Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-427344.1Reactome Database ID Release 7510696855Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10696855ReactomeR-DDI-737721Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-73772.1As the active RNA Polymerase I complex leaves the promoter Rrn3 dissociates from the complex. RNA polymerase I Promoter Clearance is complete and Chain Elongation begins (Milkereit and Tschochner, 1998). The assembly of the initiation complex on the promoter and the transition from a closed to an open complex is then followed by promoter clearance and transcription elongation by RNA Pol I. Unlike the RNA polymerase II system, RNA polymerase I transcription does not require a form of energy such as ATP for initiation and elongation. Regulatory mechanisms operating at both the level of transcription initiation and elongation probably concurrently to adjust the level of rRNA synthesis to the need of the cell.9649439Pubmed1998A specialized form of RNA polymerase I, essential for initiation and growth-dependent regulation of rRNA synthesis, is disrupted during transcriptionMilkereit, PTschochner, HEMBO J. 17:3692-70311032814Pubmed2000The recruitment of RNA polymerase I on rDNA is mediated by the interaction of the A43 subunit with Rrn3Peyroche, GMilkereit, PBischler, NTschochner, HSchultz, PSentenac, ACarles, CRiva, MEMBO J. 19:5473-82inferred by electronic annotationIEAGOIEAReactome Database ID Release 7510696851Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10696851ReactomeR-DDI-738541Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-73854.1Promoter clearance is one of the rate-limiting steps in Polymerase I transcription. This step is composed of three phases, promoter opening, transcription initiation and promoter escape.inferred by electronic annotationIEAGOIEA