BioPAX pathway converted from "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening" in the Reactome database.RNA Polymerase II Transcription Pre-Initiation And Promoter OpeningRNA Polymerase II Transcription Pre-Initiation And Promoter OpeningThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>Recognition and Binding of Core Promoter Elements by TFIIDRecognition and Binding of Core Promoter Elements by TFIIDThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>Reactome DB_ID: 106487311nucleoplasmGO0005654TFIID [nucleoplasm]TFIIDReactome DB_ID: 106487131UniProt:Q55A39TAF9Reactomehttp://www.reactome.orgDictyostelium discoideumNCBI Taxonomy44689UniProtQ55A39Chain Coordinates1EQUAL251EQUALReactome DB_ID: 106486771UniProt:Q54X70UniProtQ54X701EQUAL1085EQUALReactome DB_ID: 106486921UniProt:Q54XM9taf11UniProtQ54XM91EQUAL211EQUALReactome DB_ID: 106484611UniProt:P26355tbpAUniProtP263551EQUAL339EQUALReactome DB_ID: 106487091UniProt:C7G081taf2UniProtC7G0811EQUAL1199EQUALReactome DB_ID: 106487251UniProt:Q55BH6TAF7UniProtQ55BH61EQUAL349EQUALReactome DB_ID: 106487181UniProt:Q54DH8taf1UniProtQ54DH81EQUAL1872EQUALReactome DB_ID: 1064870411EQUAL264EQUALReactome DB_ID: 106487111Ghost homologue of TAF3 [nucleoplasm]Ghost homologue of TAF3Reactome DB_ID: 106486871UniProt:Q555L9TAF12UniProtQ555L91EQUAL161EQUALReactome DB_ID: 106486701UniProt:Q54KH7TAF5UniProtQ54KH71EQUAL800EQUALReactome DB_ID: 1064867511EQUAL862EQUALReactome DB_ID: 106486941Ghost homologue of TAF10 [nucleoplasm]Ghost homologue of TAF10Reactome DB_ID: 106487291Ghost homologue of TAF15 [nucleoplasm]Ghost homologue of TAF15Reactome DB_ID: 106486821UniProt:Q54CN8taf13UniProtQ54CN81EQUAL124EQUALReactome DB_ID: 106486991UniProt:Q54IW7TAF6UniProtQ54IW71EQUAL677EQUALReactome Database ID Release 7510648731Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10648731ReactomeR-DDI-1096261Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-109626.1Reactome DB_ID: 1096271DNA containing RNA Polymerase II promoter [nucleoplasm]DNA containing RNA Polymerase II promoterReactome DB_ID: 106493071pol II promoter:TFIID complex [nucleoplasm]pol II promoter:TFIID complexReactome DB_ID: 106487311Reactome DB_ID: 1096271Reactome Database ID Release 7510649307Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10649307ReactomeR-DDI-1096281Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-109628.1Reactome Database ID Release 7510650243Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10650243ReactomeR-DDI-1096361Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-109636.1Although TBP (TATA box binding factor) is necessary and sufficient for initiation of basal transcription, the other subunits of the general transcription factor TFIID, the TBP-associated factors, are required for response to transcriptional activators. TBP binds to the TATA box (a core promoter element), and bends the DNA 80 degrees toward the major groove. This conformation of TBP-TATA box provides the proper topology for the binding of the general transcription factor TFIIB.<p>Transcriptional activators function by affecting the kinetics of binding of TBP to the promoter DNA.8330735Pubmed1993TBP, a universal eukaryotic transcription factor?Hernandez, NouriaGenes Dev 7:1291-3088946909Pubmed1997The general transcription factors of RNA polymerase II.Orphanides, GLagrange, TReinberg, DannyGenes Dev 10:2657-83inferred by electronic annotationIEAGOIEARecruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complexRecruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complexThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>Reactome DB_ID: 106467961RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm]RNA Polymerase II (unphosphorylated):TFIIF complexReactome DB_ID: 106467941RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm]RNA Polymerase II holoenzyme complex (unphosphorylated)Reactome DB_ID: 106467501UniProt:Q54YW8polr2hUniProtQ54YW82EQUAL150EQUALReactome DB_ID: 106467701UniProt:Q55AB6polr2lUniProtQ55AB61EQUAL67EQUALReactome DB_ID: 106467201UniProt:Q86JJ5polr2jUniProtQ86JJ51EQUAL117EQUALReactome DB_ID: 106467351UniProt:Q54S04polr2dUniProtQ54S041EQUAL142EQUALReactome DB_ID: 106467921UniProt:P35084polr2aUniProtP350841EQUAL1970EQUALReactome DB_ID: 106467301UniProt:Q54J75polr2bUniProtQ54J751EQUAL1174EQUALReactome DB_ID: 106467601UniProt:Q54EH2polr2eUniProtQ54EH21EQUAL210EQUALReactome DB_ID: 106467651UniProt:Q54FA8polr2fUniProtQ54FA82EQUAL127EQUALReactome DB_ID: 106467251UniProt:Q55GG8rpb9UniProtQ55GG81EQUAL125EQUALReactome DB_ID: 106467401UniProt:Q54P04polr2gUniProtQ54P041EQUAL172EQUALReactome DB_ID: 106467551UniProt:Q54R66polr2kUniProtQ54R661EQUAL58EQUALReactome DB_ID: 106467451UniProt:Q54DH7polr2cUniProtQ54DH72EQUAL275EQUALReactome Database ID Release 7510646794Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10646794ReactomeR-DDI-1134011Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-113401.1Reactome DB_ID: 106467841TFIIF [nucleoplasm]TFIIFReactome DB_ID: 106467821UniProt:Q54KT7gtf2f2UniProtQ54KT72EQUAL249EQUALReactome DB_ID: 106467771UniProt:Q54WV4gtf2f1UniProtQ54WV42EQUAL517EQUALReactome Database ID Release 7510646784Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10646784ReactomeR-DDI-1096311Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-109631.1Reactome Database ID Release 7510646796Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10646796ReactomeR-DDI-713071Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-71307.1Reactome DB_ID: 106493091pol II promoter:TFIID:TFIIA:TFIIB complex [nucleoplasm]pol II promoter:TFIID:TFIIA:TFIIB complexReactome DB_ID: 106493071Reactome DB_ID: 106486601TFIIA [nucleoplasm]TFIIAReactome DB_ID: 106486581UniProt:Q54ND1gtf2a2UniProtQ54ND11EQUAL109EQUALReactome DB_ID: 106486511Ghost homologue of GTF2A1(1-274) [nucleoplasm]Ghost homologue of GTF2A1(1-274)Reactome DB_ID: 106486531Ghost homologue of GTF2A1(275-376) [nucleoplasm]Ghost homologue of GTF2A1(275-376)Reactome Database ID Release 7510648660Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10648660ReactomeR-DDI-1096291Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-109629.1Reactome DB_ID: 106486651UniProt:Q54FD6gtf2bUniProtQ54FD61EQUAL316EQUALReactome Database ID Release 7510649309Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10649309ReactomeR-DDI-1096301Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-109630.1Reactome DB_ID: 106493111pol II promoter:TFIID:TFIIA:TFIIB:Pol II:TFIIF complex [nucleoplasm]pol II promoter:TFIID:TFIIA:TFIIB:Pol II:TFIIF complexReactome DB_ID: 106467961Reactome DB_ID: 106493091Reactome Database ID Release 7510649311Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10649311ReactomeR-DDI-1096321Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-109632.1Reactome Database ID Release 7510650245Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10650245ReactomeR-DDI-1096381Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-109638.1The general transcription factor TFIIF has a high affinity for the RNA Polymerase II holoenzyme. TFIIF stabilizes the preinitiation complex, and suppresses non-specific binding of RNA Pol II to DNA, and is thus critical for start site recognition.inferred by electronic annotationIEAGOIEABinding of TFIIE to the growing preinitiation complexBinding of TFIIE to the growing preinitiation complexThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>Reactome DB_ID: 106493111Reactome DB_ID: 106487431TFIIE [nucleoplasm]TFIIEReactome DB_ID: 106487411UniProt:Q54KJ8gtf2e2UniProtQ54KJ81EQUAL291EQUALReactome DB_ID: 106487361UniProt:Q557M8gtf2e1-1UniProtQ557M82EQUAL439EQUALReactome Database ID Release 7510648743Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10648743ReactomeR-DDI-1096331Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-109633.1Reactome DB_ID: 106493131pol II promoter:TFIID:TFIIA:TFIIB:Pol II:TFIIF:TFIIE complex [nucleoplasm]pol II promoter:TFIID:TFIIA:TFIIB:Pol II:TFIIF:TFIIE complexReactome DB_ID: 106493111Reactome DB_ID: 106487431Reactome Database ID Release 7510649313Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10649313ReactomeR-DDI-758711Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-75871.1Reactome Database ID Release 7510649315Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10649315ReactomeR-DDI-750951Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-75095.1Factor TFIIE enters the preinitiation complex after TFIIF recruits RNA Polymerase II. TFIIE is composed of two subunits of 56 kDA and 34 kDa. TFIIE facilitates the recruitment of factor TFIIH to the preinitiation complex, and it also stimulates the phosphorylation of the RNA Polymerase II CTD by TFIIH.inferred by electronic annotationIEAGOIEAFormation of the closed pre-initiation complexFormation of the closed pre-initiation complexThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>Reactome DB_ID: 106485231TFIIH [nucleoplasm]TFIIHReactome DB_ID: 106485211UniProt:Q55CT8gtf2h5UniProtQ55CT81EQUAL71EQUALReactome DB_ID: 106484861CAK [nucleoplasm]CAKReactome DB_ID: 106484841UniProt:Q54I13mnat1UniProtQ54I131EQUAL309EQUALReactome DB_ID: 106484741UniProt:P54685cdk7UniProtP546851EQUAL346EQUALReactome DB_ID: 106484791UniProt:Q55F19cycHUniProtQ55F191EQUAL323EQUALReactome Database ID Release 7510648486Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10648486ReactomeR-DDI-692211Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-69221.1Reactome DB_ID: 106485011UniProt:Q86IB5gtf2h3UniProtQ86IB51EQUAL308EQUALReactome DB_ID: 106485061UniProt:Q86KZ2gtf2h2UniProtQ86KZ21EQUAL395EQUALReactome DB_ID: 106484911UniProt:Q55G81repDUniProtQ55G811EQUAL760EQUALReactome DB_ID: 106485161UniProt:Q55FP1gtf2h1UniProtQ55FP11EQUAL548EQUALReactome DB_ID: 106484961UniProt:O00835repBUniProtO008351EQUAL782EQUALReactome DB_ID: 106485111UniProt:Q54C29gtf2h4UniProtQ54C291EQUAL462EQUALReactome Database ID Release 7510648523Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10648523ReactomeR-DDI-1096341Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-109634.1Reactome DB_ID: 106493131Reactome DB_ID: 106493631pol II closed pre-initiation complex [nucleoplasm]pol II closed pre-initiation complexReactome DB_ID: 106485231Reactome DB_ID: 106493111Reactome DB_ID: 106487431Reactome Database ID Release 7510649363Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10649363ReactomeR-DDI-1096351Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-109635.1Reactome Database ID Release 7510650247Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10650247ReactomeR-DDI-1096391Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-109639.1The binding of TFIIH completes the assembly of the preinitiation complex (PIC) for RNA Polymerase II transcription. Although RNA polymerase binds the TATA box on the promoter DNA, no initiation of transcription occurs until TFIIH is bound to the PIC. TFIIH is the only factor with known enzymatic activities.inferred by electronic annotationIEAGOIEAReactome Database ID Release 7510696911Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10696911ReactomeR-DDI-737791Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DDI-73779.1GO0006367GO biological processFormation of the pre-initiation complex proceeds in five steps, recognition and binding of core promoter elements by TFIID, binding of TFIIA and TFIIB to the pol II promoter:TFIID complex, recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex, binding of TFIIE to the growing preinitiation complex, and formation of the closed pre-initiation complex (Orphanides et al. 1997).inferred by electronic annotationIEAGOIEA