BioPAX pathway converted from "ALAS condenses SUCC-CoA and Gly to form dALA" in the Reactome database.2.3.1.37ALAS condenses SUCC-CoA and Gly to form dALAALAS condenses SUCC-CoA and Gly to form dALASuccinyl CoA and glycine condense to form 5-aminolevulinate (ALA)This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>Reactome DB_ID: 709581mitochondrial matrixGO0005759succinyl-CoA(5-) [ChEBI:57292]succinyl-CoA(5-)succinyl-coenzyme A(5-)S-(3-carboxy-propionyl)-CoA(5-)succinyl-CoA3'-phosphonatoadenosine 5'-{3-[(3R)-4-{[3-({2-[(3-carboxylatopropanoyl)sulfanyl]ethyl}amino)-3-oxopropyl]amino}-3-hydroxy-2,2-dimethyl-4-oxobutyl]diphosphate}S-(hydrogen succinyl)CoA(5-)succinyl-CoA pentaanionReactomehttp://www.reactome.orgChEBI57292Reactome DB_ID: 1595491glycine zwitterion [ChEBI:57305]glycine zwitterionglycineDHMQDGOQFOQNFH-UHFFFAOYSA-NC2H5NO22-azaniumylacetate[NH3+]CC([O-])=OInChI=1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5)75.06660ChEBI57305Reactome DB_ID: 1135291hydron [ChEBI:15378]hydronChEBI15378Reactome DB_ID: 18946615-ammoniolevulinate [ChEBI:356416]5-ammoniolevulinate5-ammonio-4-oxovalerate5-azaniumyl-4-oxopentanoate5-ammonio-4-oxopentanoate5-aminolevulinateChEBI356416Reactome DB_ID: 293741coenzyme A [ChEBI:15346]coenzyme AChEBI15346Reactome DB_ID: 293761carbon dioxide [ChEBI:16526]carbon dioxideChEBI16526PHYSIOL-LEFT-TO-RIGHTACTIVATIONConverted from EntitySet in ReactomeReactome DB_ID: 10705260ALAS1,2 [mitochondrial matrix]Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntityGO0003870GO molecular functionReactome Database ID Release 7510705261Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10705261Reactome Database ID Release 7510705263Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10705263ReactomeR-SPO-1894421Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-189442.1The committed step for porphyrin synthesis is the formation of 5-aminolevulinate (ALA) by condensation of glycine (from the general amino acid pool) and succinyl-CoA (from the TCA cycle), in the mitochondrial matrix. The reaction is catalyzed by two different ALA synthases, one expressed ubiquitously (ALAS1) and the other only expressed in erythroid precursors (ALAS2). Both enzymes are expressed as homodimers and require pyridoxal 5-phosphate as a cofactor.<br>No disease-causing mutations of ALAS1 have been recognised in humans. Mutations in ALAS2 cause X-linked sideroblastic anaemia (XLSA), characterised by a microcytic hypochromic anaemia.16121195Pubmed2005Crystal structure of 5-aminolevulinate synthase, the first enzyme of heme biosynthesis, and its link to XLSA in humansAstner, ISchulze, JOvan den Heuvel, JJahn, DSchubert, WDHeinz, DWEMBO J 24:3166-771939222Pubmed1991Biosynthesis of delta-aminolevulinic acid and the regulation of heme formation by immature erythroid cells in manGardner, LCSmith, SJCox, Timothy MJ Biol Chem 266:22010-8inferred by electronic annotationIEAGOIEAINHIBITIONReactome Database ID Release 75189417Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=189417ReactomeR-HSA-1894171Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-189417.1Reactome DB_ID: 189444ferroheme b [ChEBI:17627]ferroheme bChEBI17627