BioPAX pathway converted from "PIAS4 SUMOylates TP53BP1 with SUMO1" in the Reactome database.PIAS4 SUMOylates TP53BP1 with SUMO1

PIAS4 SUMOylates TP53BP1 with SUMO1

Conjugation of SUMO1 to TP53BP1This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>

Reactome DB_ID: 10712982

nucleoplasmGO0005654

UniProt:P87074crb2

Reactomehttp://www.reactome.orgSchizosaccharomyces pombe

NCBI Taxonomy4896UniProtP87074

Chain Coordinates

EQUAL

1972

EQUAL

Reactome DB_ID: 10712990

SUMO1:C93-UBE2I [nucleoplasm]

SUMO1:C93-UBE2I

Reactome DB_ID: 10712988

UniProt:O13351pmt3

UniProtO13351

Inter-chain Crosslink via S-(glycyl)-L-cysteine (Cys-Gly) at 97 and 93 (in Homo sapiens)

EQUAL

S-(glycyl)-L-cysteine (Cys-Gly)ChEBI23511

modification

EQUAL

Reactome DB_ID: 10712985

UniProt:P40984hus5

UniProtP40984

Inter-chain Crosslink via S-(glycyl)-L-cysteine (Cys-Gly) at 93 and 97 (in Homo sapiens)

EQUAL

ChEBI24411

modification

EQUAL

158

EQUAL

Reactome Database ID Release 7510712990Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10712990ReactomeR-SPO-2993783

Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-2993783.1

Reactome DB_ID: 10712948

EQUAL

158

EQUAL

Reactome DB_ID: 10712998

SUMO1:TP53BP1 [nucleoplasm]

SUMO1:TP53BP1

Reactome DB_ID: 10712993

UniProt:P87074 glycyl group sumoylated lysine

sumoylated lysine

EQUAL

1972

EQUAL

Reactome DB_ID: 10712996

Inter-chain Crosslink via sumoylated lysine at 97 and unknown (in Homo sapiens)

EQUAL

ChEBI30777

modification

EQUAL

Reactome Database ID Release 7510712998Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10712998ReactomeR-SPO-3730720

Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-3730720.1PHYSIOL-LEFT-TO-RIGHT

ACTIVATION

Reactome DB_ID: 10713003

UniProt:O94451pli1

UniProtO94451

EQUAL

510

EQUAL

GO0019789

GO molecular function

Reactome Database ID Release 7510713004Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10713004Reactome Database ID Release 7510713006Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10713006ReactomeR-SPO-2997723

Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-2997723.1GO0016925

GO biological process

PIAS4 SUMOylates TP53BP1 with SUMO1 in response to double-strand breaks in DNA (Galanty et al. 2009, Impens et al. 2014). Overall, like TP53BP1, SUMO1,2,3, UBE2I, PIAS1 and PIAS4 are all observed to accumulate at double-strand breaks.

20016603Pubmed2009Mammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaksGalanty, YaronBelotserkovskaya, RimmaCoates, JuliaPolo, SophieMiller, Kyle MJackson, Stephen PNature 462:935-925114211Pubmed2014Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuliImpens, FrancisRadoshevich, LillianaCossart, PascaleRibet, DavidProc. Natl. Acad. Sci. U.S.A. 111:12432-7inferred by electronic annotationIEAGOIEA