BioPAX pathway converted from "FAAH2 hydrolyses AEA to AA and ETA" in the Reactome database. FAAH2 hydrolyses AEA to AA and ETA FAAH2 hydrolyses AEA to AA and ETA This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Reactome DB_ID: 5693752 1 lipid droplet GO 0005811 anandamide [ChEBI:2700] anandamide Reactome http://www.reactome.org ChEBI 2700 Reactome DB_ID: 5693747 1 water [ChEBI:15377] water ChEBI 15377 Reactome DB_ID: 5693733 1 arachidonate [ChEBI:32395] arachidonate (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate (20:4n6) (5Z,8Z,11Z,14Z)-eicosatetraenoate ChEBI 32395 Reactome DB_ID: 5693736 1 ethanolamine [ChEBI:16000] ethanolamine ChEBI 16000 PHYSIOL-LEFT-TO-RIGHT ACTIVATION Reactome DB_ID: 10717799 UniProt:Q7K2E1 Dmel\CG8839 Drosophila melanogaster NCBI Taxonomy 7227 UniProt Q7K2E1 Chain Coordinates 1 EQUAL 532 EQUAL GO 0017064 GO molecular function Reactome Database ID Release 82 10717800 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10717800 Reactome Database ID Release 82 10717802 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10717802 Reactome R-DME-5693751 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-5693751.1 Fatty acid amides are a class of lipid transmitters that include the endogenous cannabinoid anandamide (AEA) and the sleep-inducing chemical oleamide. The magnitude and duration of their signalling are controlled by enzymatic hydrolysis mediated by fatty-acid amide hydrolases 1 and 2 (FAAH, H2). Hydrolysis of AEA is described here (Wei et al. 2006). FAAH is localised to the ER membrane whereas FAAH2 is localised to lipid droplets (Kaczocha et al. 2010). 19926788 Pubmed 2010 Lipid droplets are novel sites of N-acylethanolamine inactivation by fatty acid amide hydrolase-2 Kaczocha, Martin Glaser, Sherrye T Chae, Janiper Brown, Deborah A Deutsch, Dale G J. Biol. Chem. 285:2796-806 17015445 Pubmed 2006 A second fatty acid amide hydrolase with variable distribution among placental mammals Wei, Binqing Q Mikkelsen, Tarjei S McKinney, Michele K Lander, Eric S Cravatt, BF J. Biol. Chem. 281:36569-78 inferred by electronic annotation IEA GO IEA