BioPAX pathway converted from "AWAT1 transfers acyl group from acyl-CoA to ARACOH, forming wax esters" in the Reactome database. 2.3.1.75 AWAT1 transfers acyl group from acyl-CoA to ARACOH, forming wax esters AWAT1 transfers acyl group from acyl-CoA to ARACOH, forming wax esters This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Reactome DB_ID: 5696426 1 endoplasmic reticulum lumen GO 0005788 icosan-1-ol [ChEBI:75627] icosan-1-ol arachidyl alcohol eicosyl alcohol eicosan-1-ol arachidic alcohol 1-eicosanol Reactome http://www.reactome.org ChEBI 75627 Reactome DB_ID: 192172 1 acyl-CoA [ChEBI:17984] acyl-CoA ChEBI 17984 Reactome DB_ID: 162743 1 coenzyme A(4-) [ChEBI:57287] coenzyme A(4-) CoA 3'-phosphonatoadenosine 5'-{3-[(3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-({3-oxo-3-[(2-sulfanylethyl)amino]propyl}amino)butyl] diphosphate} ChEBI 57287 Reactome DB_ID: 5696412 1 wax ester [ChEBI:10036] wax ester Wax esters ChEBI 10036 PHYSIOL-LEFT-TO-RIGHT ACTIVATION Converted from EntitySet in Reactome Reactome DB_ID: 10718376 endoplasmic reticulum membrane GO 0005789 Homologues of AWAT1 [endoplasmic reticulum membrane] Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntity Dmel\CG1946 [endoplasmic reticulum membrane] Dmel\CG1941 [endoplasmic reticulum membrane] Dgat2 [endoplasmic reticulum membrane] Drosophila melanogaster NCBI Taxonomy 7227 UniProt A1Z739 UniProt Q7JYK2 UniProt Q7K1C2 GO 0047196 GO molecular function Reactome Database ID Release 82 10718377 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10718377 Reactome Database ID Release 82 10718379 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10718379 Reactome R-DME-5696424 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-5696424.1 Arachidyl alcohol (ARACOH) is straight-chain fatty alcohol of C20 length used as an emollient in cosmetics. Esterification of alcohols with fatty acids represents the formation of both storage and cytoprotective molecules in the body. Overproduction of these esters is associated with several disease pathologies, including atherosclerosis and obesity. The ER membrane-associated acyl-CoA wax alcohol acyltransferase 1 (AWAT1) mediates the esterification of its preferred substrate ARACOH (Turkish et al. 2005). 15671038 Pubmed 2005 Identification of two novel human acyl-CoA wax alcohol acyltransferases: members of the diacylglycerol acyltransferase 2 (DGAT2) gene superfamily Turkish, Aaron R Henneberry, Annette L Cromley, Debra Padamsee, Mahajabeen Oelkers, P Bazzi, Hisham Christiano, Angela M Billheimer, JT Sturley, Stephen L J. Biol. Chem. 280:14755-64 inferred by electronic annotation IEA GO IEA