BioPAX pathway converted from "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening" in the Reactome database.RNA Polymerase II Transcription Pre-Initiation And Promoter OpeningRNA Polymerase II Transcription Pre-Initiation And Promoter OpeningThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>Recognition and Binding of Core Promoter Elements by TFIIDRecognition and Binding of Core Promoter Elements by TFIIDThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>Reactome DB_ID: 107019071nucleoplasmGO0005654TFIID [nucleoplasm]TFIIDReactome DB_ID: 107018581UniProt:O13722taf12Reactomehttp://www.reactome.orgSchizosaccharomyces pombeNCBI Taxonomy4896UniProtO13722Chain Coordinates1EQUAL161EQUALReactome DB_ID: 107019011UniProt:O13701taf7UniProtO137011EQUAL349EQUALConverted from EntitySet in ReactomeReactome DB_ID: 107018531Homologues of TAF13 [nucleoplasm]Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntitytaf13 [nucleoplasm]spt3 [nucleoplasm]UniProtO60076UniProtO14311Reactome DB_ID: 107018851Ghost homologue of TAF3 [nucleoplasm]Ghost homologue of TAF3Reactome DB_ID: 107018391UniProt:Q9P7S4taf4UniProtQ9P7S41EQUAL862EQUALReactome DB_ID: 107019051Ghost homologue of TAF15 [nucleoplasm]Ghost homologue of TAF15Converted from EntitySet in ReactomeReactome DB_ID: 107018961TAF1,TAF1L [nucleoplasm]Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntityTAF1 [nucleoplasm]TAF1L [nucleoplasm]UniProtQ09813Reactome DB_ID: 107016371UniProt:P17871tbp1UniProtP178711EQUAL339EQUALReactome DB_ID: 107018631UniProt:Q9US54taf11UniProtQ9US541EQUAL211EQUALReactome DB_ID: 107018681UniProt:O60171taf10UniProtO601711EQUAL218EQUALReactome DB_ID: 107018831UniProt:P87121taf2UniProtP871211EQUAL1199EQUALReactome DB_ID: 107018341UniProt:O13282taf5UniProtO132821EQUAL800EQUALReactome DB_ID: 107018871UniProt:Q09869taf9UniProtQ098691EQUAL251EQUALReactome DB_ID: 1070184111EQUAL1085EQUALReactome DB_ID: 1070187811EQUAL264EQUALReactome DB_ID: 107018731UniProt:O74462taf6UniProtO744621EQUAL677EQUALReactome Database ID Release 7510701907Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10701907ReactomeR-SPO-1096261Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-109626.1Reactome DB_ID: 1096271DNA containing RNA Polymerase II promoter [nucleoplasm]DNA containing RNA Polymerase II promoterReactome DB_ID: 107021731pol II promoter:TFIID complex [nucleoplasm]pol II promoter:TFIID complexReactome DB_ID: 107019071Reactome DB_ID: 1096271Reactome Database ID Release 7510702173Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10702173ReactomeR-SPO-1096281Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-109628.1Reactome Database ID Release 7510702938Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10702938ReactomeR-SPO-1096361Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-109636.1Although TBP (TATA box binding factor) is necessary and sufficient for initiation of basal transcription, the other subunits of the general transcription factor TFIID, the TBP-associated factors, are required for response to transcriptional activators. TBP binds to the TATA box (a core promoter element), and bends the DNA 80 degrees toward the major groove. This conformation of TBP-TATA box provides the proper topology for the binding of the general transcription factor TFIIB.<p>Transcriptional activators function by affecting the kinetics of binding of TBP to the promoter DNA.8330735Pubmed1993TBP, a universal eukaryotic transcription factor?Hernandez, NouriaGenes Dev 7:1291-3088946909Pubmed1997The general transcription factors of RNA polymerase II.Orphanides, GLagrange, TReinberg, DannyGenes Dev 10:2657-83inferred by electronic annotationIEAGOIEABinding of TFIIA and TFIIB to the pol II promoter:TFIID complexBinding of TFIIA and TFIIB to the pol II promoter:TFIID complexThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>Reactome DB_ID: 107021731Reactome DB_ID: 107018241TFIIA [nucleoplasm]TFIIAReactome DB_ID: 107018221UniProt:O74948toa2UniProtO749481EQUAL109EQUALReactome DB_ID: 107018171UniProt:Q9USU9toa1UniProtQ9USU9275EQUAL376EQUALReactome DB_ID: 1070181511EQUAL274EQUALReactome Database ID Release 7510701824Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10701824ReactomeR-SPO-1096291Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-109629.1Reactome DB_ID: 107018291UniProt:O13749sua7UniProtO137491EQUAL316EQUALReactome DB_ID: 107021751pol II promoter:TFIID:TFIIA:TFIIB complex [nucleoplasm]pol II promoter:TFIID:TFIIA:TFIIB complexReactome DB_ID: 107021731Reactome DB_ID: 107018241Reactome DB_ID: 1070182911EQUAL316EQUALReactome Database ID Release 7510702175Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10702175ReactomeR-SPO-1096301Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-109630.1Reactome Database ID Release 7510702940Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10702940ReactomeR-SPO-1096371Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-109637.1The general transcription factor TFIIB is a single polypeptide of approximately 35 kDa. There is a Zn-binding domain near the N terminus of TFIIB, and the C-terminal domain encompasses two imperfect repeats; between the N and C termini is a phylogenetically conserved region. The C terminus interacts with TBP and RNA Polymerase II, whereas the N terminus interacts with factor TFIIF and RNA polymerase II. TFIIB is a sequence-specific factor, and it interacts with the BRE element within the promoter.<p>TFIIB interacts with the Rpb1 subunit of RNA polymerase II to define transcription strat sites. Several activators directly bind TFIIB, and stimulate transcription. The N-terminus and the C-terminus can participate in intramolecular interactions, and this can be disrupted by specific activators by causing a conformational change in TFIIB.<p> TFIIA also binds the preinitiation complex along with TFIIB. However, TFIIA is not required for accurate initiation, but rather functions as a coactivator of transcription.inferred by electronic annotationIEAGOIEARecruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complexRecruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complexThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>Reactome DB_ID: 107021751Reactome DB_ID: 107005791RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm]RNA Polymerase II (unphosphorylated):TFIIF complexReactome DB_ID: 107005771RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm]RNA Polymerase II holoenzyme complex (unphosphorylated)Reactome DB_ID: 107005381UniProt:P48011rpc10UniProtP480111EQUAL58EQUALReactome DB_ID: 107005331UniProt:Q92399rpb8UniProtQ923992EQUAL150EQUALReactome DB_ID: 107005751UniProt:P36594rpb1UniProtP365941EQUAL1970EQUALReactome DB_ID: 107005431UniProt:Q09191rpb5UniProtQ091911EQUAL210EQUALReactome DB_ID: 107005231UniProt:O14459rpb7UniProtO144591EQUAL172EQUALReactome DB_ID: 107005131UniProt:Q02061rpb2UniProtQ020611EQUAL1174EQUALReactome DB_ID: 107005281UniProt:P37382rpb3UniProtP373822EQUAL275EQUALReactome DB_ID: 107005031UniProt:P87123rpb11UniProtP871231EQUAL117EQUALReactome DB_ID: 107005081UniProt:O74635rpb9UniProtO746351EQUAL125EQUALReactome DB_ID: 107005481UniProt:P36595rpb6UniProtP365952EQUAL127EQUALReactome DB_ID: 107005531UniProt:O13877rpb10UniProtO138771EQUAL67EQUALReactome DB_ID: 107005181UniProt:O74825rpb4UniProtO748251EQUAL142EQUALReactome Database ID Release 7510700577Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10700577ReactomeR-SPO-1134011Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-113401.1Reactome DB_ID: 107005671TFIIF [nucleoplasm]TFIIFReactome DB_ID: 107005651UniProt:O94424tfg2UniProtO944242EQUAL249EQUALReactome DB_ID: 107005601UniProt:O94416tfg1UniProtO944162EQUAL517EQUALReactome Database ID Release 7510700567Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10700567ReactomeR-SPO-1096311Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-109631.1Reactome Database ID Release 7510700579Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10700579ReactomeR-SPO-713071Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-71307.1Reactome DB_ID: 107021771pol II promoter:TFIID:TFIIA:TFIIB:Pol II:TFIIF complex [nucleoplasm]pol II promoter:TFIID:TFIIA:TFIIB:Pol II:TFIIF complexReactome DB_ID: 107021751Reactome DB_ID: 107005791Reactome Database ID Release 7510702177Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10702177ReactomeR-SPO-1096321Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-109632.1Reactome Database ID Release 7510702942Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10702942ReactomeR-SPO-1096381Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-109638.1The general transcription factor TFIIF has a high affinity for the RNA Polymerase II holoenzyme. TFIIF stabilizes the preinitiation complex, and suppresses non-specific binding of RNA Pol II to DNA, and is thus critical for start site recognition.inferred by electronic annotationIEAGOIEABinding of TFIIE to the growing preinitiation complexBinding of TFIIE to the growing preinitiation complexThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>Reactome DB_ID: 107019191TFIIE [nucleoplasm]TFIIEReactome DB_ID: 107019121UniProt:Q9P3W1tfa1UniProtQ9P3W12EQUAL439EQUALReactome DB_ID: 107019171UniProt:P79011tfa2UniProtP790111EQUAL291EQUALReactome Database ID Release 7510701919Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10701919ReactomeR-SPO-1096331Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-109633.1Reactome DB_ID: 107021771Reactome DB_ID: 107021791pol II promoter:TFIID:TFIIA:TFIIB:Pol II:TFIIF:TFIIE complex [nucleoplasm]pol II promoter:TFIID:TFIIA:TFIIB:Pol II:TFIIF:TFIIE complexReactome DB_ID: 107019191Reactome DB_ID: 107021771Reactome Database ID Release 7510702179Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10702179ReactomeR-SPO-758711Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-75871.1Reactome Database ID Release 7510702181Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10702181ReactomeR-SPO-750951Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-75095.1Factor TFIIE enters the preinitiation complex after TFIIF recruits RNA Polymerase II. TFIIE is composed of two subunits of 56 kDA and 34 kDa. TFIIE facilitates the recruitment of factor TFIIH to the preinitiation complex, and it also stimulates the phosphorylation of the RNA Polymerase II CTD by TFIIH.inferred by electronic annotationIEAGOIEAFormation of the closed pre-initiation complexFormation of the closed pre-initiation complexThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>Reactome DB_ID: 107016991TFIIH [nucleoplasm]TFIIHReactome DB_ID: 107016921UniProt:O13745tfb1UniProtO137451EQUAL548EQUALReactome DB_ID: 107016671UniProt:P26659rad15UniProtP266591EQUAL760EQUALReactome DB_ID: 107016871UniProt:P87303tfb2UniProtP873031EQUAL462EQUALReactome DB_ID: 107016621CAK [nucleoplasm]CAKReactome DB_ID: 107016501UniProt:Q12126crk1UniProtQ121261EQUAL346EQUALReactome DB_ID: 107016601UniProt:O94684pmh1UniProtO946841EQUAL309EQUALReactome DB_ID: 107016551UniProt:P36613mcs2UniProtP366131EQUAL323EQUALReactome Database ID Release 7510701662Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10701662ReactomeR-SPO-692211Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-69221.1Reactome DB_ID: 107016971UniProt:Q9HDW3tfb5UniProtQ9HDW31EQUAL71EQUALReactome DB_ID: 107016721UniProt:O13768ptr8UniProtO137681EQUAL782EQUALReactome DB_ID: 107016821UniProt:O74995ssl1UniProtO749951EQUAL395EQUALReactome DB_ID: 107016771UniProt:O74366tfb4UniProtO743661EQUAL308EQUALReactome Database ID Release 7510701699Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10701699ReactomeR-SPO-1096341Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-109634.1Reactome DB_ID: 107021791Reactome DB_ID: 107025441pol II closed pre-initiation complex [nucleoplasm]pol II closed pre-initiation complexReactome DB_ID: 107019191Reactome DB_ID: 107021771Reactome DB_ID: 107016991Reactome Database ID Release 7510702544Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10702544ReactomeR-SPO-1096351Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-109635.1Reactome Database ID Release 7510702944Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10702944ReactomeR-SPO-1096391Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-109639.1The binding of TFIIH completes the assembly of the preinitiation complex (PIC) for RNA Polymerase II transcription. Although RNA polymerase binds the TATA box on the promoter DNA, no initiation of transcription occurs until TFIIH is bound to the PIC. TFIIH is the only factor with known enzymatic activities.inferred by electronic annotationIEAGOIEAReactome Database ID Release 7510725474Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10725474ReactomeR-SPO-737791Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-73779.1GO0006367GO biological processFormation of the pre-initiation complex proceeds in five steps, recognition and binding of core promoter elements by TFIID, binding of TFIIA and TFIIB to the pol II promoter:TFIID complex, recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex, binding of TFIIE to the growing preinitiation complex, and formation of the closed pre-initiation complex (Orphanides et al. 1997).inferred by electronic annotationIEAGOIEA