BioPAX pathway converted from "Hydrolysis of LPC" in the Reactome database.Hydrolysis of LPCHydrolysis of LPCThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>3.1.1.51-acyl LPC is hydrolyzed to GPCho by PLA2[8]1-acyl LPC is hydrolyzed to GPCho by PLA2[8]This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>Reactome DB_ID: 15240281endoplasmic reticulum membraneGO00057891-O-acyl-sn-glycero-3-phosphocholine(1+) [ChEBI:17504]1-O-acyl-sn-glycero-3-phosphocholine(1+)Reactomehttp://www.reactome.orgChEBI17504Reactome DB_ID: 293561cytosolGO0005829water [ChEBI:15377]waterChEBI15377Reactome DB_ID: 14987501choline alfoscerate [ChEBI:16870]choline alfoscerateChEBI16870Reactome DB_ID: 15240211long-chain fatty acid anion [ChEBI:57560]long-chain fatty acid anionChEBI57560PHYSIOL-LEFT-TO-RIGHTACTIVATIONConverted from EntitySet in ReactomeReactome DB_ID: 10711187PLA2(8) [cytosol]Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntityPLA2G4F [cytosol]PLA2G4F [cytosol]PLA2G4E [cytosol]PLA2G4E [cytosol]plb1 [cytosol]PLA2G4F [cytosol]PLA2G4E [cytosol]plb1 [cytosol]plb1 [cytosol]PLA2G4F [cytosol]PLA2G4B [cytosol]plb1 [cytosol]PLA2G4F [cytosol]PLA2G4B [cytosol]PLA2G4D [cytosol]PLA2G4D [cytosol]PLA2G4B [cytosol]PLA2G4B [cytosol]PLA2G4D [cytosol]PLA2G4E [cytosol]PLA2G4E [cytosol]PLA2G4B [cytosol]PLA2G4D [cytosol]PLA2G4D [cytosol]UniProtP0CU02UniProtQ9Y7N6UniProtO13857UniProtP78854UniProtQ9UTH5UniProtP0CU03GO0004622GO molecular functionReactome Database ID Release 7510711188Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10711188Reactome Database ID Release 7510711212Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10711212ReactomeR-SPO-14826851Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-1482685.1At the endoplasmic reticulum (ER) membrane, 1-acyl lysophosphatidylcholine (LPC) is hydrolyzed to glycerophosphocholine (GPCho) by cytosolic phospholipase A2 alpha/beta/delta/epsilon/zeta (PLA2G4A/B/D/E/F) (Yamashita et al. 2005, Ghomashchi et al. 2010, Yamashita et al. 2009, Sharp et al. 1994) or by Phospholipase B1-like (PLBD1) (Xu et al. 2009). PLBD1 also acts as a phospholipase A2 but in addition has the propensity to hydrolyze the lysophospholipid formed in its initial reaction.15944408Pubmed2005Roles of C-terminal processing, and involvement in transacylation reaction of human group IVC phospholipase A2 (cPLA2gamma)Yamashita, AKamata, RKawagishi, NNakanishi, HSuzuki, HSugiura, TWaku, KJ Biochem 137:557-6719019078Pubmed2009The identification of a phospholipase B precursor in human neutrophilsXu, SZhao, LLarsson, AVenge, PFEBS J 276:175-8620705608Pubmed2010Interfacial kinetic and binding properties of mammalian group IVB phospholipase A2 (cPLA2beta) and comparison with the other cPLA2 isoformsGhomashchi, FNaika, GSBollinger, JGAloulou, AhmedLehr, MLeslie, CCGelb, Michael HJ Biol Chem 285:36100-1119501189Pubmed2009Subcellular localization and lysophospholipase/transacylation activities of human group IVC phospholipase A2 (cPLA2gamma)Yamashita, ATanaka, KKamata, RKumazawa, TSuzuki, NKoga, HWaku, KSugiura, TBiochim Biophys Acta 1791:1011-228083230Pubmed1994Serine 228 is essential for catalytic activities of 85-kDa cytosolic phospholipase A2Sharp, JDPickard, RTChiou, XGManetta, JVKovacevic, SMiller, JRVarshavsky, ADRoberts, EFStrifler, BABrems, DNJ Biol Chem 269:23250-4inferred by electronic annotationIEAGOIEA3.1.1.51-acyl LPC is hydrolyzed to GPCho by PLA2G4C1-acyl LPC is hydrolyzed to GPCho by PLA2G4CThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>Reactome DB_ID: 15240281Reactome DB_ID: 293561Reactome DB_ID: 14987501Reactome DB_ID: 15240211PHYSIOL-LEFT-TO-RIGHTACTIVATIONConverted from EntitySet in ReactomeReactome DB_ID: 10711101Homologues of PLA2G4C [endoplasmic reticulum membrane]Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntityPLA2G4C [endoplasmic reticulum membrane]PLA2G4C [endoplasmic reticulum membrane]PLA2G4C [endoplasmic reticulum membrane]plb1 [endoplasmic reticulum membrane]PLA2G4C [endoplasmic reticulum membrane]PLA2G4C [endoplasmic reticulum membrane]Schizosaccharomyces pombeNCBI Taxonomy4896Reactome Database ID Release 7510711102Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10711102Reactome Database ID Release 7510711219Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10711219ReactomeR-SPO-14826961Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-1482696.1At the endoplasmic reticulum (ER) membrane, 1-acyl lysophosphatidylcholine (LPC) is hydrolyzed to glycerophosphocholine (GPCho) by membrane-bound cytosolic phospholipase A2 gamma (PLA2G4C) (Yamashita et al. 2005, Ghomashchi et al. 2010, Yamashita et al. 2009).inferred by electronic annotationIEAGOIEA3.1.1.52-acyl LPC is hydrolyzed to GPCho by PLA2[8]2-acyl LPC is hydrolyzed to GPCho by PLA2[8]This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>Reactome DB_ID: 97561412-acyl-sn-glycero-3-phosphocholine(1+) [ChEBI:16728]2-acyl-sn-glycero-3-phosphocholine(1+)ChEBI16728Reactome DB_ID: 293561Reactome DB_ID: 14987501Reactome DB_ID: 15240211PHYSIOL-LEFT-TO-RIGHTACTIVATIONConverted from EntitySet in ReactomeReactome DB_ID: 10711187Reactome Database ID Release 7510711190Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10711190ReactomeR-SPO-14826121Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-1482612.1At the endoplasmic reticulum (ER) membrane, 2-acyl lysophosphatidylcholine (LPC) is hydrolyzed to glycerophosphocholine (GPCho) by cytosolic phospholipase A2 alpha/beta/delta/epsilon/zeta (PLA2G4A/B/D/E/F) (Yamashita et al. 2005, Ghomashchi et al. 2010, Yamashita et al. 2009, Sharp et al. 1994) or by Phospholipase B1-like (PLBD1) (Xu et al. 2009). PLBD1 also acts as a phospholipase A2 but in addition has the propensity to hydrolyze the lysophospholipid formed in its initial reaction.inferred by electronic annotationIEAGOIEA3.1.1.52-acyl LPC is hydrolyzed to GPCho by PLA2G4C2-acyl LPC is hydrolyzed to GPCho by PLA2G4CThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>Reactome DB_ID: 9756141Reactome DB_ID: 293561Reactome DB_ID: 14987501Reactome DB_ID: 15240211PHYSIOL-LEFT-TO-RIGHTACTIVATIONConverted from EntitySet in ReactomeReactome DB_ID: 10711101Reactome Database ID Release 7510711195Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10711195ReactomeR-SPO-14826291Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-1482629.1At the endoplasmic reticulum (ER) membrane, 2-acyl lysophosphatidylcholine (LPC) is hydrolyzed to glycerophosphocholine (GPCho) by membrane-bound cytosolic phospholipase A2 gamma (PLA2G4C) (Yamashita et al. 2005, Ghomashchi et al. 2010, Yamashita et al. 2009).inferred by electronic annotationIEAGOIEAReactome Database ID Release 7510726290Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10726290ReactomeR-SPO-14831151Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-SPO-1483115.1GO0006644GO biological processLysophosphatidylcholine (LPC) is hydrolyzed by phospholipases to produce glycerophosphocholine (GPCho) which is in turn hydrolyzed by glycerophosphocholine phosphodiesterase to produce choline (Cho) and glycerol-3-phosphate (G3P) (Yamashita et al. 2009, Yamashita et al. 2005, Ghomashchi et al. 2010).inferred by electronic annotationIEAGOIEA