BioPAX pathway converted from "Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter" in the Reactome database. Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Reactome DB_ID: 77087 2 nucleoplasm GO 0005654 S-adenosyl-L-methionine [ChEBI:15414] S-adenosyl-L-methionine Reactome http://www.reactome.org ChEBI 15414 Reactome DB_ID: 10740228 1 H3K4me2-Nucleosome:GP1BA gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] H3K4me2-Nucleosome:GP1BA gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B Reactome DB_ID: 10740219 1 Ghost homologue of GP1BA gene [nucleoplasm] Ghost homologue of GP1BA gene Reactome DB_ID: 10740147 1 Nucleosome with H3K4me2 [nucleoplasm] Nucleosome with H3K4me2 Reactome DB_ID: 10715458 2 Ghost homologue of HIST1H4 [nucleoplasm] Ghost homologue of HIST1H4 Converted from EntitySet in Reactome Reactome DB_ID: 10740145 2 Histone H3 (H3K4me2) [nucleoplasm] Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntity His3.3A [nucleoplasm] His3.3B [nucleoplasm] His3:CG33845 [nucleoplasm] Drosophila melanogaster NCBI Taxonomy 7227 UniProt C0HL66 UniProt C0HL67 UniProt P02299 Converted from EntitySet in Reactome Reactome DB_ID: 10715467 2 Histone H2A [nucleoplasm] Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntity Converted from EntitySet in Reactome Reactome DB_ID: 10715476 2 Histone H2B [nucleoplasm] Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntity Reactome Database ID Release 83 10740147 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10740147 Reactome R-DME-1214200 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-1214200.1 Reactome DB_ID: 10740173 1 RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B Reactome DB_ID: 10705715 1 UniProt:M9MS40 UniProt M9MS40 Chain Coordinates 2 EQUAL 2414 EQUAL Reactome DB_ID: 10712244 1 UniProt:Q9VTZ1 Gcn5 UniProt Q9VTZ1 1 EQUAL 832 EQUAL Reactome DB_ID: 10740171 1 Core MLL complex [nucleoplasm] Core MLL complex Reactome DB_ID: 10716204 1 UniProt:Q9VPH8 Rbbp5 UniProt Q9VPH8 1 EQUAL 538 EQUAL Reactome DB_ID: 10716199 1 UniProt:Q94545 ash2 UniProt Q94545 1 EQUAL 628 EQUAL Reactome DB_ID: 10740169 1 Ghost homologue of DPY30 [nucleoplasm] Ghost homologue of DPY30 Converted from EntitySet in Reactome Reactome DB_ID: 10740167 1 KMT2A-E, SETD1A,(SETD1B) [nucleoplasm] Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntity KMT2A [nucleoplasm] upSET [nucleoplasm] KMT2B [nucleoplasm] Lpt [nucleoplasm] Set1 [nucleoplasm] UniProt P20659 UniProt Q9VUB5 UniProt Q9W1H0 UniProt Q5LJZ2 Reactome DB_ID: 10718887 1 UniProt:Q9V3J8 wds UniProt Q9V3J8 2 EQUAL 334 EQUAL Reactome Database ID Release 83 10740171 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10740171 Reactome R-DME-5244738 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-5244738.1 Converted from EntitySet in Reactome Reactome DB_ID: 10740076 1 RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1 [nucleoplasm] Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntity Reactome DB_ID: 10740149 1 GATA1:ZFPM1 [nucleoplasm] GATA1:ZFPM1 Reactome DB_ID: 10704943 1 UniProt:Q9VPQ6 UniProt Q9VPQ6 1 EQUAL 1006 EQUAL Reactome DB_ID: 10704952 1 UniProt:P91623 grn UniProt P91623 1 EQUAL 413 EQUAL Reactome Database ID Release 83 10740149 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10740149 Reactome R-DME-8936469 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-8936469.1 Reactome Database ID Release 83 10740173 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10740173 Reactome R-DME-8936477 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-8936477.1 Reactome Database ID Release 83 10740228 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10740228 Reactome R-DME-8936615 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-8936615.1 Reactome DB_ID: 10740230 1 H3K4me3-Nucleosome:GP1BA gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] H3K4me3-Nucleosome:GP1BA gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B Reactome DB_ID: 10740219 1 Reactome DB_ID: 10740190 1 Nucleosome with H3K4me3 [nucleoplasm] Nucleosome with H3K4me3 Reactome DB_ID: 10715458 2 Converted from EntitySet in Reactome Reactome DB_ID: 10715467 2 Converted from EntitySet in Reactome Reactome DB_ID: 10715476 2 Converted from EntitySet in Reactome Reactome DB_ID: 10740188 2 Histone H3 (H3K4me3) [nucleoplasm] Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntity His3.3A [nucleoplasm] His3:CG33845 [nucleoplasm] His3.3B [nucleoplasm] Reactome Database ID Release 83 10740190 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10740190 Reactome R-DME-1214169 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-1214169.1 Reactome DB_ID: 10740173 1 Reactome Database ID Release 83 10740230 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10740230 Reactome R-DME-8936620 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-8936620.1 Reactome DB_ID: 77502 2 S-adenosyl-L-homocysteine [ChEBI:16680] S-adenosyl-L-homocysteine ChEBI 16680 PHYSIOL-LEFT-TO-RIGHT ACTIVATION Reactome DB_ID: 10740228 GO 0042800 GO molecular function Reactome Database ID Release 83 10740231 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10740231 Reactome Database ID Release 83 10740233 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10740233 Reactome R-DME-8936621 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-DME-8936621.1 The WDR5-containing histone methyltransferase MLL complex, recruited to the GP1BA promoter via RUNX1 (and possibly GATA1), methylates histone H3 on dimethylated lysine residue K4 (K5 when taking into account the initiator methionine), producing the H3K4me3 mark. The H3K4me3 mark is characteristic of nucleosome associated with transcriptionally active promoters of megakaryocyte-specific genes (Herglotz et al. 2013). 22777353 Pubmed 2013 Histone arginine methylation keeps RUNX1 target genes in an intermediate state Herglotz, J Kuvardina, O N Kolodziej, S Kumar, A Hussong, H Grez, M Lausen, J Oncogene 32:2565-75 inferred by electronic annotation IEA GO IEA