BioPAX pathway converted from "SEMA4D interacts with Plexin-B1:ErbB2" in the Reactome database. 2.7.10.2 SEMA4D interacts with Plexin-B1:ErbB2 SEMA4D interacts with Plexin-B1:ErbB2 This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Reactome DB_ID: 113592 1 cytosol GO 0005829 ATP(4-) [ChEBI:30616] ATP(4-) Adenosine 5'-triphosphate atp ATP Reactome http://www.reactome.org ChEBI 30616 Reactome DB_ID: 10760966 1 plasma membrane GO 0005886 Plexin-B1:ErbB2 [plasma membrane] Plexin-B1:ErbB2 Converted from EntitySet in Reactome Reactome DB_ID: 10760964 1 Homologues of PLXNB1 [plasma membrane] Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntity plx-1 [plasma membrane] plx-2 [plasma membrane] Caenorhabditis elegans NCBI Taxonomy 6239 UniProt U4PRY7 UniProt O45657 Reactome DB_ID: 10760952 1 UniProt:P24348 UniProt P24348 Chain Coordinates 23 EQUAL 1255 EQUAL Reactome Database ID Release 82 10760966 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10760966 Reactome R-CEL-419629 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-419629.1 Reactome DB_ID: 10760950 1 SEMA4D dimer [plasma membrane] SEMA4D dimer Converted from EntitySet in Reactome Reactome DB_ID: 10760939 2 Homologues of SEMA4D [plasma membrane] Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntity mab-20 [plasma membrane] smp-1 [plasma membrane] smp-2 [plasma membrane] UniProt Q95XP4 UniProt Q17330 UniProt Q9TYS4 Reactome Database ID Release 82 10760950 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10760950 Reactome R-CEL-373690 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-373690.1 Reactome DB_ID: 10760978 1 SEMA4D:ERBB2:p-Y-PLXNB1 [plasma membrane] SEMA4D:ERBB2:p-Y-PLXNB1 Reactome DB_ID: 10760950 1 Reactome DB_ID: 10760976 1 ERBB2:p-Y-PLXNB1 [plasma membrane] ERBB2:p-Y-PLXNB1 Converted from EntitySet in Reactome Reactome DB_ID: 10760974 1 Homologues of p-Y-PLXNB1 [plasma membrane] Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntity phospho-plx-2 [plasma membrane] phospho-plx-1 [plasma membrane] Reactome DB_ID: 10760952 1 23 EQUAL 1255 EQUAL Reactome Database ID Release 82 10760976 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10760976 Reactome R-CEL-419627 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-419627.1 Reactome Database ID Release 82 10760978 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10760978 Reactome R-CEL-373695 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-373695.1 Reactome DB_ID: 29370 1 ADP(3-) [ChEBI:456216] ADP(3-) ADP trianion 5&apos;-O-[(phosphonatooxy)phosphinato]adenosine ADP ChEBI 456216 PHYSIOL-LEFT-TO-RIGHT ACTIVATION Reactome DB_ID: 10760966 GO 0004713 GO molecular function Reactome Database ID Release 82 10760979 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10760979 Reactome Database ID Release 82 10760981 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10760981 Reactome R-CEL-373750 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-373750.1 Sema4D binds Plexin-B1 to induce repulsive or attractive effects in neuronal and nonneuronal cells. Plexins constitute a large family of transmembrane proteins that function as receptors for semaphorins and their interaction governs cell adhesion and migration in a variety of tissues. All B-class plexins can interact with the receptor tyrosine kinases Met and ErbB2. Upon binding of Sema4D to plexin-B1, the kinase activity of ErbB2 is increased resulting in tyrosine phosphorylation of both Plexin-B1 and ErbB2. ErbB2 has been shown to mediate Sema4D-induced growth cone collapse in hippocampal neurons by the activation of RhoA via plexinB1 and PDZRhoGEF/LARG.<br>Sequence alignment reveals the presence of 13 conserved tyrosine residues (highly conserved sites 1918, 1953, 2038) but the specific tyrosine residues phosphorylated in the cytoplasmic domain of plexins in response to semaphorin stimulation have not yet been identified. 15210733 Pubmed 2004 Plexin-B1/RhoGEF-mediated RhoA activation involves the receptor tyrosine kinase ErbB-2 Swiercz, JM Kuner, R Offermanns, S J Cell Biol 165:869-80 18025083 Pubmed 2008 ErbB-2 and met reciprocally regulate cellular signaling via plexin-B1 Swiercz, JM Worzfeld, T Offermanns, S J Biol Chem 283:1893-901 inferred by electronic annotation IEA GO IEA