BioPAX pathway converted from "TORC2 (mTOR) phosphorylates AKT at S473" in the Reactome database.
2.7.11.1
TORC2 (mTOR) phosphorylates AKT at S473
TORC2 (mTOR) phosphorylates AKT at S473
This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>
Reactome DB_ID: 113592
1
cytosol
GO
0005829
ATP(4-) [ChEBI:30616]
ATP(4-)
Adenosine 5'-triphosphate
atp
ATP
Reactome
http://www.reactome.org
ChEBI
30616
Reactome DB_ID: 10764500
1
plasma membrane
GO
0005886
AKT:PIP3 [plasma membrane]
AKT:PIP3
Converted from EntitySet in Reactome
Reactome DB_ID: 10764498
1
AKT [plasma membrane]
Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntity
AKT1 [plasma membrane]
AKT1 [plasma membrane]
Caenorhabditis elegans
NCBI Taxonomy
6239
UniProt
Q17941
UniProt
Q9XTG7
Reactome DB_ID: 179838
1
1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-) [ChEBI:57836]
1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)
2,3-bis(alkanoyloxy)propyl (1S,2S,3R,4S,5S,6S)-2,6-dihydroxy-3,4,5-tris(phosphonatooxy)cyclohexyl phosphate
ChEBI
57836
Reactome Database ID Release 83
10764500
Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10764500
Reactome
R-CEL-2317329
1
Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-2317329.1
Reactome DB_ID: 29370
1
ADP(3-) [ChEBI:456216]
ADP(3-)
ADP trianion
5'-O-[(phosphonatooxy)phosphinato]adenosine
ADP
ChEBI
456216
Reactome DB_ID: 10764518
1
p-S-AKT:PIP3 [plasma membrane]
p-S-AKT:PIP3
Converted from EntitySet in Reactome
Reactome DB_ID: 10764516
1
p-S-AKT [plasma membrane]
Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntity
phospho-p-S473-AKT1 [plasma membrane]
phospho-p-S473-AKT1 [plasma membrane]
Reactome DB_ID: 179838
1
Reactome Database ID Release 83
10764518
Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10764518
Reactome
R-CEL-2317310
1
Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-2317310.1
PHYSIOL-LEFT-TO-RIGHT
ACTIVATION
Reactome DB_ID: 10764532
TORC2 complex [cytosol]
TORC2 complex
Reactome DB_ID: 10760182
1
UniProt:P91040
mlst-8
UniProt
P91040
Chain Coordinates
1
EQUAL
326
EQUAL
Reactome DB_ID: 10764530
1
Ghost homologue of PRR5 [cytosol]
Ghost homologue of PRR5
Reactome DB_ID: 10764523
1
UniProt:G5EFN2
rict-1
UniProt
G5EFN2
1
EQUAL
1708
EQUAL
Reactome DB_ID: 10764528
1
UniProt:Q9NA80
sinh-1
UniProt
Q9NA80
2
EQUAL
522
EQUAL
Reactome DB_ID: 10760187
1
UniProt:Q95Q95
let-363
UniProt
Q95Q95
1
EQUAL
2549
EQUAL
Reactome Database ID Release 83
10764532
Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10764532
Reactome
R-CEL-198626
1
Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-198626.1
GO
0004674
GO molecular function
Reactome Database ID Release 83
10764533
Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10764533
Reactome Database ID Release 83
10764539
Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10764539
Reactome
R-CEL-198640
1
Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-198640.1
GO
0032148
GO biological process
Under conditions of growth and mitogen stimulation S473 phosphorylation of AKT is carried out by mTOR (mammalian Target of Rapamycin). This kinase is found in two structurally and functionally distinct protein complexes, named TOR complex 1 (TORC1) and TOR complex 2 (TORC2). It is TORC2 complex, which is composed of mTOR, RICTOR, SIN1 (also named MAPKAP1) and LST8, that phosphorylates AKT at S473 (Sarbassov et al., 2005). This complex also regulates actin cytoskeletal reorganization (Jacinto et al., 2004; Sarbassov et al., 2004). TORC1, on the other hand, is a major regulator of ribosomal biogenesis and protein synthesis (Hay and Sonenberg, 2004). TORC1 regulates these processes largely by the phosphorylation/inactivation of the repressors of mRNA translation 4E binding proteins (4E BPs) and by the phosphorylation/activation of ribosomal S6 kinase (S6K1). TORC1 is also the principal regulator of autophagy. In other physiological conditions, other kinases may be responsible for AKT S473 phosphorylation.<br>
Phosphorylation of AKT on S473 by TORC2 complex is a prerequisite for AKT phosphorylation on T308 by PDPK1 (Scheid et al. 2002, Sarabassov et al. 2005).
15314020
Pubmed
2004
Upstream and downstream of mTOR
Hay, N
Sonenberg, Nahum
Genes Dev 18:1926-45
19303758
Pubmed
2009
PIKKing on PKB: regulation of PKB activity by phosphorylation
Bozulic, L
Hemmings, BA
Curr Opin Cell Biol 21:256-61
12167717
Pubmed
2002
Multiple phosphoinositide 3-kinase-dependent steps in activation of protein kinase B
Scheid, MP
Marignani, PA
Woodgett, JR
Mol Cell Biol 22:6247-60
15718470
Pubmed
2005
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
Sarbassov, DD
Guertin, DA
Ali, SM
Sabatini, DM
Science 307:1098-101
15268862
Pubmed
2004
Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton
Sarbassov, DD
Ali, SM
Kim, DH
Guertin, DA
Latek, RR
Erdjument-Bromage, H
Tempst, P
Sabatini, DM
Curr Biol 14:1296-302
15467718
Pubmed
2004
Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive
Jacinto, E
Loewith, R
Schmidt, A
Lin, S
Ruegg, MA
Hall, A
Hall, MN
Nat Cell Biol 6:1122-8
inferred by electronic annotation
IEA
GO
IEA
INHIBITION
Reactome Database ID Release 83
10764540
Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10764540
Reactome DB_ID: 10764537
AKT:PIP3:THEM4/TRIB3 [plasma membrane]
AKT:PIP3:THEM4/TRIB3
Reactome DB_ID: 10764535
1
UniProt:G5EED4
UniProt
G5EED4
1
EQUAL
358
EQUAL
Reactome DB_ID: 10764500
1
Reactome Database ID Release 83
10764537
Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10764537
Reactome
R-CEL-199453
1
Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-199453.1