BioPAX pathway converted from "GPX4-2 reduces 17(S)-Hp-DHA to 17(S)-HDHA" in the Reactome database.1.11.1.12GPX4-2 reduces 17(S)-Hp-DHA to 17(S)-HDHAGPX4-2 reduces 17(S)-Hp-DHA to 17(S)-HDHAThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>Reactome DB_ID: 294502cytosolGO0005829glutathione [ChEBI:16856]glutathioneReactomehttp://www.reactome.orgChEBI16856Reactome DB_ID: 90240121(4Z,7Z,10Z,13Z,15E,17S,19Z)-17-hydroperoxydocosahexaenoic acid [ChEBI:136113](4Z,7Z,10Z,13Z,15E,17S,19Z)-17-hydroperoxydocosahexaenoic acidChEBI136113Reactome DB_ID: 1117451glutathione disulfide [ChEBI:17858]glutathione disulfideChEBI17858Reactome DB_ID: 9024815117(S)-HDoHE [ChEBI:138640]17(S)-HDoHEChEBI138640Reactome DB_ID: 293561water [ChEBI:15377]waterChEBI15377PHYSIOL-LEFT-TO-RIGHTACTIVATIONReactome DB_ID: 10772266UniProt:Q8I5T2Plasmodium falciparumNCBI Taxonomy5833UniProtQ8I5T2Chain Coordinates28EQUAL197EQUALGO0047066GO molecular functionReactome Database ID Release 7510772267Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10772267Reactome Database ID Release 7510772275Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10772275ReactomeR-PFA-90202731Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-PFA-9020273.1Cytosolic phospholipid hydroperoxide glutathione peroxidase (GPX4 isoform 2, GPX4-2) (Yagi et al. 1996) is a likely candidate for the reduction of organic hydroperoxides such as 17(S)-hydroperoxy-docosahexaenoic acid (17(S)-Hp-DHA) to 17(S)-hydroxydocosahexaenoic acid (17(S)-HDHA) (Han et al. 2013) using glutathione (GSH) as an electron donor (Brigelius-Flohe & Maiorino 2013).24170573Pubmed2013Expression and characterization of recombinant human phospholipid hydroperoxide glutathione peroxidaseHan, XiaoFan, ZhenlinYu, YangLiu, ShaoliHao, YazhouHuo, RuiWei, JingyanIUBMB Life 65:951-68605014Pubmed1996Expression of human phospholipid hydroperoxide glutathione peroxidase gene for protection of host cells from lipid hydroperoxide-mediated injuryYagi, KKomura, SKojima, HSun, QNagata, NOhishi, NNishikimi, MBiochem. Biophys. Res. Commun. 219:486-9123201771Pubmed2013Glutathione peroxidasesBrigelius-Flohé, ReginaMaiorino, MatildeBiochim. Biophys. Acta 1830:3289-303inferred by electronic annotationIEAGOIEA