BioPAX pathway converted from "Activation of Rap1 by membrane-associated GEFs" in the Reactome database. Activation of Rap1 by membrane-associated GEFs Activation of Rap1 by membrane-associated GEFs This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Reactome DB_ID: 29438 1 cytosol GO 0005829 GTP(4-) [ChEBI:37565] GTP(4-) GTP gtp guanosine 5'-triphosphate(4-) Reactome http://www.reactome.org ChEBI 37565 Reactome DB_ID: 10760565 1 plasma membrane GO 0005886 RAP1:GDP [plasma membrane] RAP1:GDP Reactome DB_ID: 10760488 1 UniProt:Q18246 Caenorhabditis elegans NCBI Taxonomy 6239 UniProt Q18246 Chain Coordinates 1 EQUAL 181 EQUAL Reactome DB_ID: 29420 1 GDP(3-) [ChEBI:58189] GDP(3-) guanosine 5'-diphosphate(3-) 5'-O-[(phosphonatooxy)phosphinato]guanosine guanosine 5'-diphosphate trianion GDP GDP trianion guanosine 5'-diphosphate ChEBI 58189 Reactome Database ID Release 82 10760565 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10760565 Reactome R-CEL-354074 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-354074.1 Reactome DB_ID: 10760490 1 RAP1:GTP [plasma membrane] RAP1:GTP Reactome DB_ID: 29438 1 Reactome DB_ID: 10760488 1 1 EQUAL 181 EQUAL Reactome Database ID Release 82 10760490 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10760490 Reactome R-CEL-354126 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-354126.1 Reactome DB_ID: 29420 1 PHYSIOL-LEFT-TO-RIGHT ACTIVATION Converted from EntitySet in Reactome Reactome DB_ID: 10764089 Rap1 cAMP-GEFs [plasma membrane] Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntity RAPGEF3 [plasma membrane] RAPGEF4 [plasma membrane] UniProt P34578 GO 0005085 GO molecular function Reactome Database ID Release 82 10772646 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10772646 Reactome Database ID Release 82 10772648 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10772648 Reactome R-CEL-939265 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-939265.1 Signals from agonist receptors (such as GPVI) trigger the production of PIP3, DAG, cAMP and elevated Ca++ levels. This leads to the activation and translocation of active Rap1-GTP to the plasma membrane. Rap-GEFs stimulate the replacement of GDP for GTP, activating Rap1. Several Rap1 GEFs have been identified enabling Rap1 to respond to diverse stimuli. CalDAG-GEFs activate Rap1 in response to calcium and DAG, downstream of Phospholipase C. EPAC (exchange proteins directly activated by cAMP) GEFs are activated by binding cAMP. 15334074 Pubmed 2004 CalDAG-GEFI integrates signaling for platelet aggregation and thrombus formation Crittenden, JR Bergmeier, W Zhang, Y Piffath, CL Liang, Y Wagner, DD Housman, DE Graybiel, AM Nat Med 10:982-6 15469846 Pubmed 2004 RIAM, an Ena/VASP and Profilin ligand, interacts with Rap1-GTP and mediates Rap1-induced adhesion Lafuente, EM van Puijenbroek, AA Krause, M Carman, CV Freeman, GJ Berezovskaya, A Constantine, E Springer, TA Gertler, FB Boussiotis, VA Dev Cell 7:585-95 12585966 Pubmed 2003 Bidirectional integrin alphaIIbbeta3 signalling regulating platelet adhesion under flow: contribution of protein kinase C Giuliano, S Nesbitt, WS Rooney, M Jackson, SP Biochem J 372:163-72 16757337 Pubmed 2006 Rap1 regulation of RIAM and cell adhesion Lafuente, E Boussiotis, VA Methods Enzymol 407:345-58 16076873 Pubmed 2005 Multiple roles of Rap1 in hematopoietic cells: complementary versus antagonistic functions Stork, PJ Dillon, TJ Blood 106:2952-61 inferred by electronic annotation IEA GO IEA