BioPAX pathway converted from "Generation of second messenger molecules" in the Reactome database.Generation of second messenger moleculesGeneration of second messenger moleculesThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>Translocation of PLC-gamma1 to PIP2Translocation of PLC-gamma1 to PIP2This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>Reactome DB_ID: 1798561plasma membraneGO00058861-phosphatidyl-1D-myo-inositol 4,5-bisphosphate [ChEBI:18348]1-phosphatidyl-1D-myo-inositol 4,5-bisphosphatePIP2Reactomehttp://www.reactome.orgChEBI18348Reactome DB_ID: 107709651cytosolGO0005829UniProt:Q8IJR0Plasmodium falciparumNCBI Taxonomy5833UniProtQ8IJR0O4'-phospho-L-tyrosine at 771 (in Homo sapiens)771EQUALO4'-phospho-L-tyrosine [MOD:00048]O4'-phospho-L-tyrosine at 783 (in Homo sapiens)783EQUALO4'-phospho-L-tyrosine at 1253 (in Homo sapiens)1253EQUALChain Coordinates2EQUAL1290EQUALReactome DB_ID: 107709701Activated PLC gamma1 bound to PIP2 [plasma membrane]Activated PLC gamma1 bound to PIP2Reactome DB_ID: 107709681O4'-phospho-L-tyrosine at 472 (in Homo sapiens)472EQUALO4'-phospho-L-tyrosine at 771 (in Homo sapiens)771EQUALO4'-phospho-L-tyrosine at 783 (in Homo sapiens)783EQUALO4'-phospho-L-tyrosine at 1253 (in Homo sapiens)1253EQUAL2EQUAL1290EQUALReactome DB_ID: 1798561Reactome Database ID Release 7010770970Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10770970ReactomeR-PFA-2022691Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-PFA-202269.1Reactome Database ID Release 7010770972Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10770972ReactomeR-PFA-2023541Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-PFA-202354.1Activated PLA-gamma1 translocates to the plasmamembrane and interacts with the inositol ring of the membrane bound phosphatidylinositol 4,5-bisphosphate (PIP2) with its PH domain. 11048639Pubmed2000The mechanism of phospholipase C-gamma1 regulationKim, MJKim, ERyu, SHSuh, PGExp Mol Med 32:101-9inferred by electronic annotationIEAGOIEA3.1.4.11PLC-gamma1 hydrolyses PIP2PLC-gamma1 hydrolyses PIP2This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>Reactome DB_ID: 293561water [ChEBI:15377]waterChEBI15377Reactome DB_ID: 1798561Reactome DB_ID: 11452011D-myo-inositol 1,4,5-trisphosphate [ChEBI:16595]1D-myo-inositol 1,4,5-trisphosphateChEBI16595Reactome DB_ID: 1122751diglyceride [ChEBI:18035]diglycerideChEBI18035PHYSIOL-LEFT-TO-RIGHTACTIVATIONReactome DB_ID: 10770970GO0004435GO molecular functionReactome Database ID Release 7010770973Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10770973Reactome Database ID Release 7010770975Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10770975ReactomeR-PFA-2024071Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-PFA-202407.1On recruitment to plasma membrane PLC-gamma1 then hydrolyses PIP2 producing two second messengers, diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). IP3 induces a transient increase in intracellular free Ca++, while DAG is a direct activator of protein kinase C (PKC theta). These process have been implicated in many cellular physiological functions like cell proliferation, cell growth and differentiation. inferred by electronic annotationIEAGOIEAReactome Database ID Release 7010785088Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10785088ReactomeR-PFA-2024331Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-PFA-202433.1In addition to serving as a scaffold via auto-phosphorylation, ZAP-70 also phosphorylates a restricted set of substrates following TCR stimulation - including LAT and SLP-76. These substrates have been recognized to play pivotal role in TCR signaling by releasing second messengers. When phosphorylated, LAT and SLP-76 act as adaptor proteins which serve as nucleation points for the construction of a higher order signalosome: GADS, PLC-gamma1 and GRB2 bind to the LAT on the phosphorylated tyrosine residues (steps 8 and 13). SLP-76 and SOS are then moved to the signalosome by interacting with the SH3 domains of GRB2 and GADS via their proline rich sequences (step 9). Three SLP-76 acidic domain N-term tyrosine residues are phosphorylated by ZAP-70, once SLP-76 binds to GADS (step 10). These phospho-tyrosine residues act as binding sites to the SH2 domains of PLC-gamma1, Vav and Itk (steps 11 and 12). <p>PLC-gamma1 is activated by dual phosphorylation on the tyrosine residues at positions 771, 783 and 1254 by Itk and ZAP-70 (step 14). Phosphorylated PLC-gamma1 subsequently detaches from LAT and SLP-76 and translocates to the plasma membrane by binding to phosphatidylinositol-4,5-bisphosphate (PIP2) via its PH domain (step 15). PLC-gamma1 goes on to hydrolyse PIP2 to second messengers DAG and IP3. These second messengers are involved in PKC and NF-kB activation and calcium mobilization (step 16). 15084594Pubmed2004T cell receptor signaling: beyond complex complexesHuang, YWange, RLJ Biol Chem 279:28827-30inferred by electronic annotationIEAGOIEA