BioPAX pathway converted from "AKT binds PDPK1" in the Reactome database. AKT binds PDPK1 AKT binds PDPK1 This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Reactome DB_ID: 10757975 1 plasma membrane GO 0005886 PDPK1:PIP3 [plasma membrane] PDPK1:PIP3 Reactome DB_ID: 179838 1 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-) [ChEBI:57836] 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-) a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) 2,3-bis(alkanoyloxy)propyl (1S,2S,3R,4S,5S,6S)-2,6-dihydroxy-3,4,5-tris(phosphonatooxy)cyclohexyl phosphate Reactome http://www.reactome.org ChEBI 57836 Reactome DB_ID: 10757973 1 UniProt:Q9UA62 Caenorhabditis elegans NCBI Taxonomy 6239 UniProt Q9UA62 Chain Coordinates 1 EQUAL 556 EQUAL Reactome Database ID Release 83 10757975 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10757975 Reactome R-CEL-109697 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-109697.1 Reactome DB_ID: 10764518 1 p-S-AKT:PIP3 [plasma membrane] p-S-AKT:PIP3 Converted from EntitySet in Reactome Reactome DB_ID: 10764516 1 p-S-AKT [plasma membrane] Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntity phospho-p-S473-AKT1 [plasma membrane] phospho-p-S473-AKT1 [plasma membrane] UniProt Q17941 UniProt Q9XTG7 Reactome DB_ID: 179838 1 Reactome Database ID Release 83 10764518 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10764518 Reactome R-CEL-2317310 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-2317310.1 Reactome DB_ID: 10792324 1 p-S-AKT:PDPK1:PIP3 [plasma membrane] p-S-AKT:PDPK1:PIP3 Reactome DB_ID: 10757975 1 Reactome DB_ID: 10764518 1 Reactome Database ID Release 83 10792324 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10792324 Reactome R-CEL-2317313 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-2317313.1 Reactome Database ID Release 83 10792326 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10792326 Reactome R-CEL-2317314 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CEL-2317314.1 GO 0032148 GO biological process Once phosphorylated on serine residue S473, AKT bound to PIP3 forms a complex with PIP3-bound PDPK1 i.e. PDK1 (Scheid et al. 2002, Sarabassov et al. 2005) 12167717 Pubmed 2002 Multiple phosphoinositide 3-kinase-dependent steps in activation of protein kinase B Scheid, MP Marignani, PA Woodgett, JR Mol Cell Biol 22:6247-60 15718470 Pubmed 2005 Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex Sarbassov, DD Guertin, DA Ali, SM Sabatini, DM Science 307:1098-101 inferred by electronic annotation IEA GO IEA