BioPAX pathway converted from "SPRY2 translocates to the plasma membrane" in the Reactome database.SPRY2 translocates to the plasma membraneSPRY2 translocates to the plasma membraneSPRY2 translocates to the plasma membrane upon activation of cells with FGF, and translocation is required for the inhibition of growth factor-stimulated cell migration, proliferation and differentiation. Translocation may be mediated by interactions with PIP2 in the membrane, palmitoylation of the C-terminal region of SPRY2 and/or interactions with caveolin-1.Authored: Rothfels, K, 2011-08-15Reviewed: Gotoh, N, 2011-08-26Reactome DB_ID: 12955931cytosolGO0005829PPA2A(A:C):SPRY2 [cytosol]PPA2A(A:C):SPRY2PPA2A (A:C):Sprouty2Reactome DB_ID: 1829491UniProt:O43597 SPRY2SPRY2SPRY2FUNCTION May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis.SUBUNIT Interacts with RAF1 (PubMed:12717443). Part of a tripartite complex containing GAB1, METTL13 and SPRY2 (PubMed:29408807). Interacts with METTL13 (PubMed:29408807).INDUCTION By FGF signaling.DOMAIN The Cys-rich domain is responsible for the localization of the protein to the membrane ruffles.PTM Cleaved at Pro-144 by the prolyl endopeptidase FAP (seprase) activity (in vitro).SIMILARITY Belongs to the sprouty family.Reactomehttp://www.reactome.orgHomo sapiensNCBI Taxonomy9606UniProtO43597Chain Coordinates1EQUAL315EQUALReactome DB_ID: 9345441PP2A (A:C) [cytosol]PP2A (A:C)Converted from EntitySet in ReactomeReactome DB_ID: 9346151PP2A (Calpha/Cbeta) [cytosol]Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntityPPP2CB [cytosol]PPP2CA [cytosol]UniProtP62714UniProtP67775Reactome DB_ID: 1659821UniProt:P30153 PPP2R1APPP2R1APPP2R1AFUNCTION The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Upon interaction with GNA12 promotes dephosphorylation of microtubule associated protein TAU/MAPT (PubMed:15525651). Required for proper chromosome segregation and for centromeric localization of SGO1 in mitosis (PubMed:16580887).SUBUNIT Found in a complex with at least ARL2, PPP2CB, PPP2R1A, PPP2R2A, PPP2R5E and TBCD (By similarity). Interacts with FOXO1; the interaction dephosphorylates FOXO1 on AKT-mediated phosphorylation sites (By similarity). PP2A consists of a common heterodimeric core enzyme, composed of PPP2CA a 36 kDa catalytic subunit (subunit C) and PPP2R1A a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with IPO9 (PubMed:12670497). Interacts with TP53 and SGO1 (PubMed:17245430, PubMed:16580887). Interacts with PLA2G16; this interaction might decrease PP2A activity (PubMed:17374643). Interacts with CTTNBP2NL (PubMed:18782753). Interacts with GNA12; the interaction promotes protein phosphatase 2A activation causing dephosphorylation of MAPT (PubMed:15525651). Interacts with CIP2A; this interaction stabilizes CIP2A (PubMed:28174209). Interacts with FAM122A (PubMed:27588481). Interacts with ADCY8; antagonizes interaction between ADCY8 and calmodulin (By similarity). Interacts with CRTC3 (when phosphorylated at 'Ser-391') (PubMed:30611118).DOMAIN Each HEAT repeat appears to consist of two alpha helices joined by a hydrophilic region, the intrarepeat loop. The repeat units may be arranged laterally to form a rod-like structure.SIMILARITY Belongs to the phosphatase 2A regulatory subunit A family.UniProtP301532EQUAL589EQUALReactome Database ID Release 70934544Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=934544ReactomeR-HSA-9345441Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-934544.1Reactome Database ID Release 701295593Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1295593ReactomeR-HSA-12955931Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1295593.1Reactome DB_ID: 9345501plasma membraneGO0005886PP2A(A:C):SPRY2 [plasma membrane]PP2A(A:C):SPRY2PP2A (A:C):Sprouty 2Reactome DB_ID: 18292411EQUAL315EQUALReactome DB_ID: 9345441Reactome Database ID Release 70934550Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=934550ReactomeR-HSA-9345501Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-934550.1Reactome Database ID Release 701295599Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1295599ReactomeR-HSA-12955991Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1295599.111279012Pubmed2001The C terminus of sprouty is important for modulation of cellular migration and proliferationYigzaw, YCartin, LPierre, SScholich, KPatel, TBJ Biol Chem 276:22742-711238463Pubmed2001Mammalian sprouty-1 and -2 are membrane-anchored phosphoprotein inhibitors of growth factor signaling in endothelial cellsImpagnatiello, MAWeitzer, SGannon, GCompagni, ACotten, MChristofori, GJ Cell Biol 152:1087-9812391162Pubmed2002The cysteine-rich sprouty translocation domain targets mitogen-activated protein kinase inhibitory proteins to phosphatidylinositol 4,5-bisphosphate in plasma membranesLim, JYusoff, PWong, ESChandramouli, SLao, DHFong, CWGuy, GRMol Cell Biol 22:7953-6610887178Pubmed2000Sprouty proteins are targeted to membrane ruffles upon growth factor receptor tyrosine kinase activation. Identification of a novel translocation domainLim, JWong, ESOng, SHYusoff, PLow, BCGuy, GRJ Biol Chem 275:32837-45