BioPAX pathway converted from "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane" in the Reactome database.3.1.3.66PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membranePI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membraneAt the early endosome membrane, type I (INPP4A) (Norris et al. 1995, Ivetac et al. 2005) and type II inositol-3,4-bisphosphate 4-phosphatase (INPP4B) (Norris et al. 1997) colocalise with early and recycling endosomes through their C2 domains which bind to the phosphatidylinositol 3,4-bisphosphate (PI(3,4)P2) present in these membranes. It is here that phosphatidylinositol 3,4-bisphosphate (PI(3,4)P2) is dephosphorylated by INPP4A/B to phosphatidylinositol 3-phosphate (PI3P).Authored: Williams, MG, 2011-10-18Reviewed: Wakelam, Michael, 2012-05-14Edited: Williams, MG, 2011-08-12Reactome DB_ID: 18062381early endosome membraneGO00319011-phosphatidyl-1D-myo-inositol 3,4-bisphosphate [ChEBI:16152]1-phosphatidyl-1D-myo-inositol 3,4-bisphosphateReactomehttp://www.reactome.orgChEBI16152Reactome DB_ID: 293561cytosolGO0005829water [ChEBI:15377]waterChEBI15377Reactome DB_ID: 180620011-phosphatidyl-1D-myo-inositol 3-phosphate [ChEBI:17283]1-phosphatidyl-1D-myo-inositol 3-phosphate1,2-Diacyl-sn-glycero-3-phospho-(1'-myo-inositol-3'-phosphate)PtdIns3PPtdIns-3-PPhosphatidylinositol 3-phosphateChEBI17283Reactome DB_ID: 293721hydrogenphosphate [ChEBI:43474]hydrogenphosphate[PO3(OH)](2-)HYDROGENPHOSPHATE IONhydrogen phosphate[P(OH)O3](2-)HPO4(2-)phosphateINORGANIC PHOSPHATE GROUPChEBI43474PHYSIOL-LEFT-TO-RIGHTACTIVATIONConverted from EntitySet in ReactomeReactome DB_ID: 1806281INPP4A/B [cytosol]Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntityINPP4B [cytosol]INPP4A [cytosol]Homo sapiensNCBI Taxonomy9606UniProtO15327UniProtQ96PE3GO0016316GO molecular functionReactome Database ID Release 751806174Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1806174Reactome Database ID Release 751676162Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1676162ReactomeR-HSA-16761621Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-1676162.115716355Pubmed2005The type Ialpha inositol polyphosphate 4-phosphatase generates and terminates phosphoinositide 3-kinase signals on endosomes and the plasma membraneIvetac, IMunday, ADKisseleva, MVZhang, XMLuff, STiganis, TWhisstock, JCRowe, TMajerus, PWMitchell, CAMol Biol Cell 16:2218-337608176Pubmed1995The isolation and characterization of cDNA encoding human and rat brain inositol polyphosphate 4-phosphataseNorris, FAAuethavekiat, VMajerus, PWJ Biol Chem 270:16128-339295334Pubmed1997The cDNA cloning and characterization of inositol polyphosphate 4-phosphatase type II. Evidence for conserved alternative splicing in the 4-phosphatase familyNorris, FAAtkins, RCMajerus, PWJ Biol Chem 272:23859-64