BioPAX pathway converted from "HMGCR dimer reduces bHMG-CoA to MVA" in the Reactome database.1.1.1.34HMGCR dimer reduces bHMG-CoA to MVAHMGCR dimer reduces bHMG-CoA to MVAReduction of HMG-CoA produces mevalonateDimeric 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR dimer) catalyzes the four-electron reduction of beta-hydroxy-beta-methylglutaryl-CoA (bHMG-CoA) to mevalonate (MVA). MVA concentrations in the cell are tightly controlled through the activity of HMGCR dimer, which is one of the most highly regulated enzymes in metabolism (Goldstein & Brown 1990).Authored: Jassal, B, 2007-01-24 15:15:12Reviewed: D'Eustachio, P, 2007-01-22 01:32:07Reactome DB_ID: 293642cytosolGO0005829NADPH [ChEBI:16474]NADPHTPNHReactomehttp://www.reactome.orgChEBI16474Reactome DB_ID: 1913741(3S)-3-hydroxy-3-methylglutaryl-CoA [ChEBI:15467](3S)-3-hydroxy-3-methylglutaryl-CoAChEBI15467Reactome DB_ID: 701062hydron [ChEBI:15378]hydronChEBI15378Reactome DB_ID: 293662NADP(+) [ChEBI:18009]NADP(+)ChEBI18009Reactome DB_ID: 1914241(R)-mevalonic acid [ChEBI:17710](R)-mevalonic acidChEBI17710Reactome DB_ID: 761941coenzyme A [ChEBI:15346]coenzyme AChEBI15346PHYSIOL-LEFT-TO-RIGHTACTIVATIONReactome DB_ID: 191277endoplasmic reticulum membraneGO0005789HMGCR dimer [endoplasmic reticulum membrane]HMGCR dimerHydroxymethyl glutaryl CoA reductase homodimerConverted from EntitySet in ReactomeReactome DB_ID: 1913552Hydroxymethyl glutaryl CoA reductase [endoplasmic reticulum membrane]Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntityHMGCR-1 [endoplasmic reticulum membrane]HMGCR-2 [endoplasmic reticulum membrane]Homo sapiensNCBI Taxonomy9606UniProtP04035-1UniProtP04035-2Reactome Database ID Release 75191277Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=191277ReactomeR-HSA-1912771Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-191277.1GO0004420GO molecular functionReactome Database ID Release 75191301Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=191301Reactome Database ID Release 75191352Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=191352ReactomeR-HSA-1913522Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-191352.21967820Pubmed1990Regulation of the mevalonate pathwayGoldstein, JLBrown, MSNature 343:425-3010698924Pubmed2000Crystal structure of the catalytic portion of human HMG-CoA reductase: insights into regulation of activity and catalysisIstvan, ESPalnitkar, MBuchanan, SKDeisenhofer, JEMBO J 19:819-30