BioPAX pathway converted from "CD200 binds to CD200R" in the Reactome database.CD200 binds to CD200RCD200 binds to CD200RWhile not ubiquitously distributed, CD200 is expressed on a wide range of cell types including thymocytes, B-cells, activated T-cells, follicular dendritic cells, endothelium, CNS neurons in the central nervous system, cells in reproductive organs, keratinocytes and renal glomeruli. CD200R is a myeloid-inhibitory receptor, despite the absence of classical ITIMs in the cytoplasmic portion of the protein. Interestingly, CD200 is also expressed on neurons within the CNS and would be predicted to modulate activation of microglia through CD200R.Authored: de Bono, B, 2007-07-08 12:58:15Reviewed: Trowsdale, J, 2007-08-06Reviewed: Barrow, Alexander D, 2015-05-12Reactome DB_ID: 1977601plasma membraneGO0005886UniProt:P41217 CD200CD200My033MOX2CD200MOX1FUNCTION Costimulates T-cell proliferation. May regulate myeloid cell activity in a variety of tissues.SUBUNIT CD200 and CD200R1 interact via their respective N-terminal Ig-like domains.Reactomehttp://www.reactome.orgHomo sapiensNCBI Taxonomy9606UniProtP41217Chain Coordinates31EQUAL278EQUALReactome DB_ID: 1977611UniProt:Q8TD46 CD200R1CD200R1CD200R1CRTR2MOX2RUNQ2522/PRO6015CD200ROX2RFUNCTION Inhibitory receptor for the CD200/OX2 cell surface glycoprotein. Limits inflammation by inhibiting the expression of proinflammatory molecules including TNF-alpha, interferons, and inducible nitric oxide synthase (iNOS) in response to selected stimuli. Also binds to HHV-8 K14 viral CD200 homolog with identical affinity and kinetics as the host CD200.SUBUNIT CD200 and CD200R1 interact via their respective N-terminal Ig-like domains (By similarity). Interacts with Human herpesvirus 8 vOX2 protein.SUBUNIT (Microbial infection) Interacts with human herpesvirus 8/HHV-8 protein vOX2/K14.TISSUE SPECIFICITY Expressed in granulocytes, monocytes, most T-cells, neutrophils, basophils and a subset of NK, NKT and B-cells (at protein level). Expressed in bone marrow, lymph nodes, spleen, lung, liver, spinal cord, kidney. Expressed in monocyte-derived dendritic and mast cells.PTM The mature form of isoform 2 and/or isoform 4 starts at sequence position 27 of the corresponding isoform.SIMILARITY Belongs to the CD200R family.UniProtQ8TD4629EQUAL325EQUALReactome DB_ID: 1981911CD200 bound to CD200R [plasma membrane]CD200 bound to CD200RReactome DB_ID: 197760131EQUAL278EQUALReactome DB_ID: 197761129EQUAL325EQUALReactome Database ID Release 75198191Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=198191ReactomeR-HSA-1981911Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-198191.1Reactome Database ID Release 75199154Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=199154ReactomeR-HSA-1991542Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-199154.216928187Pubmed2006Is the CD200/CD200 receptor interaction more than just a myeloid cell inhibitory signal?Minas, KLiversidge, JCrit Rev Immunol 26:213-3015187158Pubmed2004CD200 is a ligand for all members of the CD200R family of immunoregulatory moleculesGorczynski, RChen, ZKai, YLee, LWong, SMarsden, PAJ Immunol 172:7744-9