BioPAX pathway converted from "Type II receptor phosphorylates type I receptor" in the Reactome database.Type II receptor phosphorylates type I receptorType II receptor phosphorylates type I receptorFormation of the hetero-tetrameric BMP2:receptor complex induces receptor rotation, so that their cytoplasmic kinase domains face each other in a catalytically favourable configuration. The constitutively active type II receptor kinase (which auto-phosphorylates in the absence of ligand), trans-phosphorylates specific serine residues at the conserved Gly-Ser-rich juxtapositioned domain of the type I receptor. It is not known if exactly 8 ATPs are required for the phosphorylation of type I receptor, there could be more or less than this number.Authored: Huminiecki, L, Moustakas, A, 2007-11-07 10:22:00Reviewed: Heldin, CH, 2007-11-12Reactome DB_ID: 2014591plasma membraneGO0005886BMP:BMPRII:BMPRI [plasma membrane]BMP:BMPRII:BMPRIDimeric BMP2:BMP type II:type I receptor complexBMP:BMPRReactome DB_ID: 2026401BMPRII:BMPRI [plasma membrane]BMPRII:BMPRIHeteromeric BMP receptor complexBMPR tetramerReactome DB_ID: 2014281BMPRI dimer [plasma membrane]BMPRI dimerBMP type I receptor dimerBMPR1A homodimerConverted from EntitySet in ReactomeReactome DB_ID: 2018052Type I receptor [plasma membrane]Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntityBMPR1B [plasma membrane]BMPR1A [plasma membrane]Reactomehttp://www.reactome.orgHomo sapiensNCBI Taxonomy9606UniProtO00238UniProtP36894Reactome Database ID Release 75201428Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=201428ReactomeR-HSA-2014281Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-201428.1Reactome DB_ID: 2014651BMPRII dimer [plasma membrane]BMPRII dimerBMP type II receptor dimerConverted from EntitySet in ReactomeReactome DB_ID: 2018042Type II receptor [plasma membrane]Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntityACVR2A [plasma membrane]ACVR2B [plasma membrane]BMPR2 [plasma membrane]UniProtP27037UniProtQ13705UniProtQ13873Reactome Database ID Release 75201465Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=201465ReactomeR-HSA-2014651Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-201465.1Reactome Database ID Release 75202640Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=202640ReactomeR-HSA-2026401Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-202640.1Reactome DB_ID: 2014631extracellular regionGO0005576BMP2 dimer [extracellular region]BMP2 dimerReactome DB_ID: 2014562UniProt:P12643 BMP2BMP2BMP2BMP2AFUNCTION Induces cartilage and bone formation (PubMed:3201241). Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4 (PubMed:24362451).SUBUNIT Homodimer; disulfide-linked (PubMed:10074410). Interacts with SOSTDC1 (PubMed:15020244). Interacts with GREM2, RGMA, RGMB and RGMC. Interacts with ASPN (By similarity). Interacts with MAFP5 (By similarity). Interacts with FBN1 (via N-terminal domain) and FBN2 (PubMed:18339631).TISSUE SPECIFICITY Particularly abundant in lung, spleen and colon and in low but significant levels in heart, brain, placenta, liver, skeletal muscle, kidney, pancreas, prostate, ovary and small intestine.PHARMACEUTICAL Available under the name Infuse (Medtronic Sofamor Danek). Used for treating open tibial shaft fractures.SIMILARITY Belongs to the TGF-beta family.UniProtP12643Chain Coordinates283EQUAL396EQUALReactome Database ID Release 75201463Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=201463ReactomeR-HSA-2014632Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-201463.2Reactome Database ID Release 75201459Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=201459ReactomeR-HSA-2014591Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-201459.1Reactome DB_ID: 1135928cytosolGO0005829ATP(4-) [ChEBI:30616]ATP(4-)Adenosine 5'-triphosphateatpATPChEBI30616Reactome DB_ID: 2014261BMP:BMPRII:p-4S-BMPRI [plasma membrane]BMP:BMPRII:p-4S-BMPRIBMP:BMPRII:P-BMPRIDimeric BMP2:BMP type II receptor:Phospho-BMP type I receptor complexReactome DB_ID: 2014631Reactome DB_ID: 2014651Reactome DB_ID: 2014471p-4S-BMPRI dimer [plasma membrane]p-4S-BMPRI dimerPhospho-BMP type I receptor dimerConverted from EntitySet in ReactomeReactome DB_ID: 2018262p-4S-BMPRI [plasma membrane]Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntityp-4S-BMPR1B [plasma membrane]p-4S-BMPR1A [plasma membrane]Reactome Database ID Release 75201447Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=201447ReactomeR-HSA-2014471Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-201447.1Reactome Database ID Release 75201426Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=201426ReactomeR-HSA-2014261Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-201426.1Reactome DB_ID: 293708ADP(3-) [ChEBI:456216]ADP(3-)ADP trianion5'-O-[(phosphonatooxy)phosphinato]adenosineADPChEBI456216PHYSIOL-LEFT-TO-RIGHTACTIVATIONReactome DB_ID: 201459GO0016362GO molecular functionReactome Database ID Release 75201455Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=201455Reactome Database ID Release 75201443Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=201443ReactomeR-HSA-2014432Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-201443.27791754Pubmed1995Human type II receptor for bone morphogenic proteins (BMPs): extension of the two-kinase receptor model to the BMPsLiu, FVentura, FDoody, JMassague, JMol Cell Biol 15:3479-867644468Pubmed1995Cloning and characterization of a human type II receptor for bone morphogenetic proteinsRosenzweig, BLImamura, TOkadome, TCox, GNYamashita, Hten Dijke, PHeldin, Carl-HenrikMiyazono, KProc Natl Acad Sci U S A 92:7632-6