BioPAX pathway converted from "Association of profilin with monomeric actin" in the Reactome database. Association of profilin with monomeric actin Association of profilin with monomeric actin Profilins PFN1 and PFN2 bind to monomeric actin (G-actin), forming a 1:1 complex and subsequently regulate actin filament barbed end assembly downstream of various signaling pathways (Pring et al. 1992, Korenbaum et al. 1998, Nodelman et al. 1999) Authored: Pollard, T, 2007-09-30 10:07:47 Reviewed: Rivero Crespo, Francisco, 2014-12-26 Edited: Orlic-Milacic, Marija, 2015-02-02 Reactome DB_ID: 201857 1 cytosol GO 0005829 G-actin [cytosol] G-actin actin:ATP Converted from EntitySet in Reactome Reactome DB_ID: 201859 1 actin [cytosol] Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntity ACTG1 [cytosol] ACTB(1-375) [cytosol] Reactome http://www.reactome.org Homo sapiens NCBI Taxonomy 9606 UniProt P63261 UniProt P60709 Reactome DB_ID: 113592 1 ATP(4-) [ChEBI:30616] ATP(4-) Adenosine 5'-triphosphate atp ATP ChEBI 30616 Reactome Database ID Release 81 201857 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=201857 Reactome R-HSA-201857 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-201857.3 Converted from EntitySet in Reactome Reactome DB_ID: 203077 1 PFN [cytosol] Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntity Reactome DB_ID: 203080 1 Profilin:G-actin [cytosol] Profilin:G-actin PFN1,PFN2:G-actin Profilin:monomeric actin Reactome DB_ID: 201857 1 Converted from EntitySet in Reactome Reactome DB_ID: 203077 1 Reactome Database ID Release 81 203080 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=203080 Reactome R-HSA-203080 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-203080.1 Reactome Database ID Release 81 203070 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=203070 Reactome R-HSA-203070 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-203070.1 9649308 Pubmed 1998 The role of profilin in actin polymerization and nucleotide exchange Korenbaum, E Nordberg, P Björkegren-Sjögren, C Schutt, C E Lindberg, U Karlsson, R Biochemistry 37:9274-83 1737036 Pubmed 1992 Profilin-actin complexes directly elongate actin filaments at the barbed end Pring, M Weber, A Bubb, M R Biochemistry 31:1827-36 10600384 Pubmed 1999 X-ray structure determination of human profilin II: A comparative structural analysis of human profilins Nodelman, IM Bowman, GD Lindberg, U Schutt, CE J Mol Biol 294:1271-85