BioPAX pathway converted from "HNF1A-dependent synthesis of GLUT2 protein" in the Reactome database. HNF1A-dependent synthesis of GLUT2 protein HNF1A-dependent synthesis of GLUT2 protein The GLUT2 gene is transcribed, its mRNA is translated, and the protein product is localized to the plasma membrane. GLUT2 expression is positively regulated by HNF1A. In vivo, pancreatic GLUT2 expression is positively regulated by HNF1A. Mutations in HNF1A are associated with a form of MODY (maturity onset diabetes of the young) (Fanjans et al. 2001) and interactions between the HNF1A protein product and the GLUT2 promoter have been demomstrated in vitro (Ban et al. 2002). However, the molecular details of GLUT2 expression in intact pancreatic beta cells have not been studied in humans, but are inferred from corresponding ones worked out in the mouse. Authored: Ferrer, J, Tello-Ruiz, MK, 2008-05-23 Reviewed: Jensen, J, 2008-05-12 21:46:53 Edited: D'Eustachio, P, 2008-05-12 21:43:33 Reactome DB_ID: 9606135 1 nucleoplasm GO 0005654 ENSEMBL:ENSG00000163581 SLC2A2 GLUT2 SLC2A2 Reactome http://www.reactome.org Homo sapiens NCBI Taxonomy 9606 ENSEMBL ENSG00000163581 Reactome DB_ID: 70421 1 plasma membrane GO 0005886 UniProt:P11168 SLC2A2 SLC2A2 GLUT2 SLC2A2 FUNCTION Facilitative hexose transporter that mediates the transport of glucose, fructose and galactose (PubMed:8027028, PubMed:16186102, PubMed:23396969, PubMed:28083649, PubMed:8457197). Likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells; may comprise part of the glucose-sensing mechanism of the beta cell (PubMed:8027028). May also participate with the Na(+)/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney (PubMed:3399500). Also able to mediate the transport of dehydroascorbate (PubMed:23396969).ACTIVITY REGULATION D-glucose and maltose competitively inhibit fructose transport (PubMed:8457197). D-glucose, D-fructose and maltose inhibit deoxyglucose transport (PubMed:8457197). Glucose and fructose transport are inhibited by flavonoids such as epigallocatechin gallate, apigenin and quercetin (PubMed:29548810).TISSUE SPECIFICITY Liver, insulin-producing beta cell, small intestine and kidney.PTM N-glycosylated; required for stability and retention at the cell surface of pancreatic beta cells.SIMILARITY Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily. UniProt P11168 Chain Coordinates 1 EQUAL 524 EQUAL Reactome Database ID Release 82 211476 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=211476 Reactome R-HSA-211476 2 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-211476.2 11978637 Pubmed 2002 Hepatocyte nuclear factor-1alpha recruits the transcriptional co-activator p300 on the GLUT2 gene promoter Ban, N Yamada, Y Someya, Y Miyawaki, K Ihara, Y Hosokawa, M Toyokuni, S Tsuda, K Seino, Y Diabetes 51:1409-18 11575290 Pubmed 2001 Molecular mechanisms and clinical pathophysiology of maturity-onset diabetes of the young Fajans, SS Bell, Graeme I Polonsky, KS N Engl J Med 345:971-80 ACTIVATION Reactome Database ID Release 82 211497 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=211497 Reactome R-HSA-211497 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-211497.1 Reactome DB_ID: 3004629 UniProt:P20823 HNF1A HNF1A HNF1A TCF1 FUNCTION Transcriptional activator that regulates the tissue specific expression of multiple genes, especially in pancreatic islet cells and in liver (By similarity). Binds to the inverted palindrome 5'-GTTAATNATTAAC-3' (PubMed:12453420, PubMed:10966642). Activates the transcription of CYP1A2, CYP2E1 and CYP3A11 (By similarity).SUBUNIT Binds DNA as a dimer (PubMed:12453420). Heterotetramer with PCBD1; formed by a dimer of dimers (By similarity). Interacts with PCBD1 (PubMed:10966642). Interacts with BHLHE41 (By similarity).TISSUE SPECIFICITY Liver.POLYMORPHISM The Ala-98/Val-98 polymorphism is associated with a reduction in glucose-induced serum C-peptide and insulin responses.SIMILARITY Belongs to the HNF1 homeobox family. UniProt P20823 1 EQUAL 631 EQUAL