BioPAX pathway converted from "HNF1A-dependent synthesis of FOXA3" in the Reactome database. HNF1A-dependent synthesis of FOXA3 HNF1A-dependent synthesis of FOXA3 The FOXA3 gene is transcribed, its mRNA is translated, and the protein product is localized to the nucleoplasm. FOXA3 expression is positively regulated by HNF1A. The molecular details of FOXA3 expression in intact pancreatic beta cells have not been studied in humans, but are inferred from corresponding ones worked out in the mouse (Boj et al. 2001). Authored: Ferrer, J, Tello-Ruiz, MK, 2008-05-23 Reviewed: Jensen, J, 2008-05-12 21:46:53 Edited: D'Eustachio, P, 2008-05-12 21:43:33 Reactome DB_ID: 9606124 1 nucleoplasm GO 0005654 ENSEMBL:ENSG00000170608 FOXA3 TCF3G FOXA3 HNF3G Reactome http://www.reactome.org Homo sapiens NCBI Taxonomy 9606 ENSEMBL ENSG00000170608 Reactome DB_ID: 211484 1 UniProt:P55318 FOXA3 FOXA3 TCF3G FOXA3 HNF3G FUNCTION Transcription factor that is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites (By similarity). Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; binds to and activates transcription from the G6PC1 promoter. Binds to the CYP3A4 promoter and activates its transcription in cooperation with CEBPA. Binds to the CYP3A7 promoter together with members of the CTF/NF-I family. Involved in regulation of neuronal-specific transcription. May be involved in regulation of spermatogenesis.SUBUNIT Interacts with FOXA2.TISSUE SPECIFICITY Expressed in erythroleukemia and hepatoma cell lines and in liver and pancreas. Not expressed in any other cell lines or tissues examined.DEVELOPMENTAL STAGE Detected in prenatal liver nuclear extracts (12.4-27 weeks estimated gestational age). Not detected in postnatal liver samples. UniProt P55318 Chain Coordinates 1 EQUAL 350 EQUAL Reactome Database ID Release 82 211482 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=211482 Reactome R-HSA-211482 2 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-211482.2 11717395 Pubmed 2001 A transcription factor regulatory circuit in differentiated pancreatic cells Boj, SF Parrizas, M Maestro, MA Ferrer, Jorge Proc Natl Acad Sci U S A 98:14481-6 ACTIVATION Reactome Database ID Release 82 211493 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=211493 Reactome R-HSA-211493 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-211493.1 Reactome DB_ID: 3004629 UniProt:P20823 HNF1A HNF1A HNF1A TCF1 FUNCTION Transcriptional activator that regulates the tissue specific expression of multiple genes, especially in pancreatic islet cells and in liver (By similarity). Binds to the inverted palindrome 5'-GTTAATNATTAAC-3' (PubMed:12453420, PubMed:10966642). Activates the transcription of CYP1A2, CYP2E1 and CYP3A11 (By similarity).SUBUNIT Binds DNA as a dimer (PubMed:12453420). Heterotetramer with PCBD1; formed by a dimer of dimers (By similarity). Interacts with PCBD1 (PubMed:10966642). Interacts with BHLHE41 (By similarity).TISSUE SPECIFICITY Liver.POLYMORPHISM The Ala-98/Val-98 polymorphism is associated with a reduction in glucose-induced serum C-peptide and insulin responses.SIMILARITY Belongs to the HNF1 homeobox family. UniProt P20823 1 EQUAL 631 EQUAL