BioPAX pathway converted from "GSSeSG is reduced to GSSeH and GSH by Gsr" in the Reactome database. GSSeSG is reduced to GSSeH and GSH by Gsr GSSeSG is reduced to GSSeH and GSH by Gsr In the rat cytosol, glutathione reductase (Gsr) homodimer is involved in the reduction of selenodiglutathione (GSSeSG) into gluthathioselenol (GSSeH) and reduced glutathione (GSH) (Bjornstedt et al. 1992). Authored: Williams, MG, 2014-05-06 Reviewed: Rush, MG, 2015-08-30 Edited: D'Eustachio, Peter, 2015-08-29 Reactome DB_ID: 29364 1 cytosol GO 0005829 NADPH(4-) [ChEBI:57783] NADPH(4-) NADPH 2'-O-phosphonatoadenosine 5'-{3-[1-(3-carbamoyl-1,4-dihydropyridin-1-yl)-1,4-anhydro-D-ribitol-5-yl] diphosphate} NADPH tetraanion Reactome http://www.reactome.org ChEBI 57783 Reactome DB_ID: 70106 1 hydron [ChEBI:15378] hydron ChEBI 15378 Reactome DB_ID: 5357667 1 selenodiglutathione(2-) [ChEBI:71259] selenodiglutathione(2-) selenodiglutathione GSSeSG(2-) ChEBI 71259 Reactome DB_ID: 29450 1 glutathionate(1-) [ChEBI:57925] glutathionate(1-) glutathionate anion glutathionate ion glutathione glutathionate ChEBI 57925 Reactome DB_ID: 5357664 1 glutathioselenol [ChEBI:64729] glutathioselenol GSSeH ChEBI 64729 Reactome DB_ID: 29366 1 NADP(3-) [ChEBI:58349] NADP(3-) NADP(+) 2'-O-phosphonatoadenosine 5'-{3-[1-(3-carbamoylpyridinio)-1,4-anhydro-D-ribitol-5-yl] diphosphate} NADP trianion ChEBI 58349 PHYSIOL-LEFT-TO-RIGHT ACTIVATION Reactome DB_ID: 5357643 2xGsr-2:2xFAD [cytosol] 2xGsr-2:2xFAD glutathione reductase holoenzyme Reactome DB_ID: 29386 2 FAD(3-) [ChEBI:57692] FAD(3-) FAD FAD trianion ChEBI 57692 Reactome DB_ID: 5357649 2 UniProt:P70619 Gsr Gsr Gsr FUNCTION Maintains high levels of reduced glutathione in the cytosol.SUBUNIT Homodimer; disulfide-linked.SIMILARITY Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. Rattus norvegicus NCBI Taxonomy 10116 UniProt P70619 Chain Coordinates 1 EQUAL 424 EQUAL Reactome Database ID Release 82 5357643 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5357643 Reactome R-RNO-5357643 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-RNO-5357643.1 GO 0098622 GO molecular function Reactome Database ID Release 82 5359072 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5359072 Reactome Database ID Release 82 2408514 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2408514 Reactome R-RNO-2408514 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-RNO-2408514.1 1569062 Pubmed 1992 Selenodiglutathione is a highly efficient oxidant of reduced thioredoxin and a substrate for mammalian thioredoxin reductase Björnstedt, M Kumar, S Holmgren, Arne J. Biol. Chem. 267:8030-4