BioPAX pathway converted from "Sec-tRNA(Sec):EEFSEC:GTP binds to 80S Ribosome" in the Reactome database.Sec-tRNA(Sec):EEFSEC:GTP binds to 80S RibosomeSec-tRNA(Sec):EEFSEC:GTP binds to 80S RibosomeThe complex consisting of selenocysteinyl (Sec) transfer RNA (tRNA) for Sec (Sec-tRNASec), selenocysteine-specific elongation factor (EEFSEC) aka SelB, selenocysteine insertion sequence-binding protein 2 (SECISBP2) aka SBP2 and GTP interacts with the 80S ribosomal protein complex (80S:Met-tRNAi:mRNA). This reaction is inferred from events occurring in rats.Authored: Williams, MG, 2014-05-06Reviewed: Rush, MG, 2015-08-30Edited: D'Eustachio, Peter, 2015-08-29Reactome DB_ID: 53590361cytosolGO0005829Sec-tRNA(Sec):EEFSEC:GTP [cytosol]Sec-tRNA(Sec):EEFSEC:GTPReactome DB_ID: 53576711UniProt:P57772 EEFSECEEFSECEEFSECSELBFUNCTION Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP.SIMILARITY Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. SelB subfamily.Reactomehttp://www.reactome.orgHomo sapiensNCBI Taxonomy9606UniProtP57772Chain Coordinates1EQUAL596EQUALReactome DB_ID: 53577081Sec-tRNA(Sec) [cytosol]Sec-tRNA(Sec)Reactome DB_ID: 294381GTP [ChEBI:15996]GTPGuanosine 5'-triphosphateChEBI15996Reactome Database ID Release 755359036Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5359036ReactomeR-HSA-53590361Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5359036.1Reactome DB_ID: 53577151UniProt:Q96T21 SECISBP2SECISBP2SECISBP2SBP2FUNCTION Binds to the SECIS element in the 3'-UTR of some mRNAs encoding selenoproteins. Binding is stimulated by SELB.SUBUNIT Interacts with SELB.TISSUE SPECIFICITY Expressed at high levels in testis.UniProtQ96T211EQUAL854EQUALReactome DB_ID: 72505180S:Met-tRNAi:mRNA [cytosol]80S:Met-tRNAi:mRNAReactome DB_ID: 723931Met-tRNAi [cytosol]Met-tRNAimethionyl initiator tRNAMet-tRNAffMet-tRNAReactome DB_ID: 72500180S ribosome [cytosol]80S ribosome80S monosomeReactome DB_ID: 72499160S ribosomal complex [cytosol]60S ribosomal complexConverted from EntitySet in ReactomeReactome DB_ID: 88688471RPL22,RPL22L1 [cytosol]Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntityRPL22 [cytosol]UniProtP35268Reactome DB_ID: 724441UniProt:P46779 RPL28RPL28RPL28FUNCTION Component of the large ribosomal subunit.SUBUNIT Component of the large ribosomal subunit.SIMILARITY Belongs to the eukaryotic ribosomal protein eL28 family.UniProtP467792EQUAL137EQUALReactome DB_ID: 724881UniProt:P62424 RPL7ARPL7ARPL7ASURF3SURF-3SUBUNIT Interacts with CRY1 (By similarity). Interacts with DICER1, AGO2, TARBP2, MOV10 and EIF6; they form a large RNA-induced silencing complex (RISC) (PubMed:17507929).DISEASE Chromosomal recombination involving RPL7A activates the receptor kinase domain of the TRK oncogene.SIMILARITY Belongs to the eukaryotic ribosomal protein eL8 family.UniProtP624242EQUAL266EQUALReactome DB_ID: 724581UniProt:P49207 RPL34RPL34RPL34FUNCTION Component of the large ribosomal subunit.SUBUNIT Component of the large ribosomal subunit.SIMILARITY Belongs to the eukaryotic ribosomal protein eL34 family.UniProtP492072EQUAL117EQUALReactome DB_ID: 724541UniProt:P62899 RPL31RPL31RPL31SIMILARITY Belongs to the eukaryotic ribosomal protein eL31 family.UniProtP628991EQUAL125EQUALReactome DB_ID: 724661UniProt:P61927 RPL37RPL37RPL37FUNCTION Binds to the 23S rRNA.SIMILARITY Belongs to the eukaryotic ribosomal protein eL37 family.UniProtP619272EQUAL97EQUALReactome DB_ID: 724961EMBL:J01866 5.8S rRNA5.8S rRNAEMBLJ01866Reactome DB_ID: 724261UniProt:P46778 RPL21RPL21RPL21FUNCTION Component of the large ribosomal subunit.SUBUNIT Component of the large ribosomal subunit.SIMILARITY Belongs to the eukaryotic ribosomal protein eL21 family.UniProtP467782EQUAL160EQUALReactome DB_ID: 724461UniProt:P47914 RPL29RPL29RPL29FUNCTION Component of the large ribosomal subunit.SUBUNIT Component of the large ribosomal subunit.SIMILARITY Belongs to the eukaryotic ribosomal protein eL29 family.UniProtP479142EQUAL159EQUALReactome DB_ID: 724781UniProt:P62945 RPL41RPL41RPL41FUNCTION Interacts with the beta subunit of protein kinase CKII and stimulates phosphorylation of DNA topoisomerase II alpha by CKII.SIMILARITY Belongs to the eukaryotic ribosomal protein eL41 family.CAUTION There are multiple pseudogenes of this gene dispersed through the genome.UniProtP629451EQUAL25EQUALReactome DB_ID: 724001UniProt:P05387 RPLP2RPLP2D11S2243ERPP2RPLP2FUNCTION Plays an important role in the elongation step of protein synthesis.SUBUNIT Heterodimer with RPLP1 at the lateral ribosomal stalk of the large ribosomal subunit.SIMILARITY Belongs to the eukaryotic ribosomal protein P1/P2 family.UniProtP053871EQUAL115EQUALReactome DB_ID: 724201UniProt:Q07020 RPL18RPL18RPL18FUNCTION Component of the large ribosomal subunit.SUBUNIT Component of the large ribosomal subunit.SIMILARITY Belongs to the eukaryotic ribosomal protein eL18 family.UniProtQ070202EQUAL188EQUALConverted from EntitySet in ReactomeReactome DB_ID: 88688271RPL26,RPL26L1 [cytosol]Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntityRPL26 [cytosol]UniProtP61254Reactome DB_ID: 724921UniProt:P32969 RPL9RPL9OK/SW-cl.103RPL9P7RPL9P8RPL9P9RPL9SIMILARITY Belongs to the universal ribosomal protein uL6 family.UniProtP329691EQUAL192EQUALReactome DB_ID: 724821UniProt:P46777 RPL5RPL5RPL5MSTP030FUNCTION Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. As part of the 5S RNP/5S ribonucleoprotein particle it is an essential component of the LSU, required for its formation and the maturation of rRNAs (PubMed:12962325, PubMed:19061985, PubMed:24120868, PubMed:23636399). It also couples ribosome biogenesis to p53/TP53 activation. As part of the 5S RNP it accumulates in the nucleoplasm and inhibits MDM2, when ribosome biogenesis is perturbed, mediating the stabilization and the activation of TP53 (PubMed:24120868).SUBUNIT Component of the large ribosomal subunit (LSU). Part of a LSU subcomplex, the 5S RNP which is composed of the 5S RNA, RPL5 and RPL11 (PubMed:24120868). Interacts with isoform 1 of NVL in an ATP-dependent manner (PubMed:15469983). Interacts with RRP1B (PubMed:20926688).SIMILARITY Belongs to the universal ribosomal protein uL18 family.UniProtP467772EQUAL297EQUALReactome DB_ID: 724141UniProt:P50914 RPL14RPL14RPL14FUNCTION Component of the large ribosomal subunit.SUBUNIT Component of the large ribosomal subunit.POLYMORPHISM The poly-Ala stretch is highly polymorphic.SIMILARITY Belongs to the eukaryotic ribosomal protein eL14 family.UniProtP509142EQUAL215EQUALReactome DB_ID: 724041UniProt:P62906 RPL10ARPL10ANEDD6RPL10AFUNCTION Component of the large ribosomal subunit.SUBUNIT Component of the large ribosomal subunit.SIMILARITY Belongs to the universal ribosomal protein uL1 family.UniProtP629062EQUAL217EQUALReactome DB_ID: 724901UniProt:P62917 RPL8RPL8RPL8FUNCTION Component of the large ribosomal subunit.SUBUNIT Component of the large ribosomal subunit (Probable). Interacts with CRY1 (By similarity).PTM Hydroxylated on His-216 by RIOX1. The modification is impaired by hypoxia.MISCELLANEOUS This protein can be partially incorporated into E.coli polysomes in vivo, indicating it can replace the endogenous protein.SIMILARITY Belongs to the universal ribosomal protein uL2 family.UniProtP629172EQUAL257EQUALReactome DB_ID: 724241UniProt:P84098 RPL19RPL19RPL19PTM Citrullinated by PADI4.SIMILARITY Belongs to the eukaryotic ribosomal protein eL19 family.UniProtP840981EQUAL196EQUALReactome DB_ID: 723981UniProt:P05386 RPLP1RPLP1RPLP1RRP1FUNCTION Plays an important role in the elongation step of protein synthesis.SUBUNIT Heterodimer with RPLP2 at the lateral ribosomal stalk of the large ribosomal subunit.SIMILARITY Belongs to the eukaryotic ribosomal protein P1/P2 family.UniProtP053862EQUAL114EQUALReactome DB_ID: 724301UniProt:P62829 RPL23RPL23RPL23SIMILARITY Belongs to the universal ribosomal protein uL14 family.UniProtP628291EQUAL140EQUALReactome DB_ID: 723961UniProt:P05388 RPLP0RPLP0RPLP0FUNCTION Ribosomal protein P0 is the functional equivalent of E.coli protein L10.SUBUNIT P0 forms a pentameric complex by interaction with dimers of P1 and P2 (PubMed:3323886). Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs (PubMed:17289661). Interacts with APEX1 (PubMed:19188445). Interacts with FMR1 isoform 6 (PubMed:24658146).SIMILARITY Belongs to the universal ribosomal protein uL10 family.UniProtP053881EQUAL317EQUALReactome DB_ID: 724621UniProt:P18077 RPL35ARPL35ARPL35AGIG33FUNCTION Required for the proliferation and viability of hematopoietic cells. Plays a role in 60S ribosomal subunit formation. The protein was found to bind to both initiator and elongator tRNAs and consequently was assigned to the P site or P and A site.MISCELLANEOUS Knockdown of RPL35A in hematopoietic cell lines results in decreased cell proliferation, increased apoptosis, decreased biogenesis of mature 60S ribosomal subunit, and abnormal processing of large ribosomal subunit rRNA.SIMILARITY Belongs to the eukaryotic ribosomal protein eL33 family.UniProtP180771EQUAL110EQUALReactome DB_ID: 724101UniProt:P26373 RPL13RPL13BBC1OK/SW-cl.46RPL13FUNCTION Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:31630789, PubMed:23636399). The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules (Probable). The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain (Probable). The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (Probable). As part of the LSU, it is probably required for its formation and the maturation of rRNAs (PubMed:31630789). Plays a role in bone development (PubMed:31630789).SUBUNIT Component of the 60S large ribosomal subunit (LSU).TISSUE SPECIFICITY Higher levels of expression in benign breast lesions than in carcinomas.SIMILARITY Belongs to the eukaryotic ribosomal protein eL13 family.UniProtP263731EQUAL211EQUALReactome DB_ID: 724061UniProt:P62913 RPL11RPL11RPL11FUNCTION Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. As part of the 5S RNP/5S ribonucleoprotein particle it is an essential component of the LSU, required for its formation and the maturation of rRNAs (PubMed:19061985, PubMed:12962325, PubMed:24120868). It also couples ribosome biogenesis to p53/TP53 activation. As part of the 5S RNP it accumulates in the nucleoplasm and inhibits MDM2, when ribosome biogenesis is perturbed, mediating the stabilization and the activation of TP53 (PubMed:24120868). Promotes nucleolar location of PML (By similarity).SUBUNIT Component of the large ribosomal subunit (LSU). Part of a LSU subcomplex, the 5S RNP which is composed of the 5S RNA, RPL5 and RPL11 (PubMed:24120868). Interacts with PML (By similarity). Interacts with MDM2; negatively regulates MDM2-mediated TP53 ubiquitination and degradation (PubMed:24120868). Interacts with NOP53; retains RPL11 into the nucleolus (PubMed:24556985, PubMed:27829214).SIMILARITY Belongs to the universal ribosomal protein uL5 family.UniProtP629132EQUAL178EQUALConverted from EntitySet in ReactomeReactome DB_ID: 88688121RPL39,RPL39L [cytosol]Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntityRPL39 [cytosol]UniProtP62891Reactome DB_ID: 724221UniProt:Q02543 RPL18ARPL18ARPL18ASUBUNIT Binds IPO9 with high affinity.SIMILARITY Belongs to the eukaryotic ribosomal protein eL20 family.UniProtQ025431EQUAL176EQUALReactome DB_ID: 724341UniProt:P83731 RPL24RPL24RPL24SIMILARITY Belongs to the eukaryotic ribosomal protein eL24 family.UniProtP837311EQUAL157EQUALConverted from EntitySet in ReactomeReactome DB_ID: 88688541RPL10,RPL10L [cytosol]Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntityRPL10 [cytosol]UniProtP27635Reactome DB_ID: 724761UniProt:P62987 UBA52UBA52UBCEP2UBA52SUBUNIT Ribosomal protein L40 is part of the 60S ribosomal subunit. Interacts with UBQLN1 (via UBA domain).MISCELLANEOUS Ubiquitin is encoded by 4 different genes. UBA52 and RPS27A genes code for a single copy of ubiquitin fused to the ribosomal proteins L40 and S27a, respectively. UBB and UBC genes code for a polyubiquitin precursor with exact head to tail repeats, the number of repeats differ between species and strains.MISCELLANEOUS For a better understanding, features related to ubiquitin are only indicated for the first chain.SIMILARITY In the N-terminal section; belongs to the ubiquitin family.SIMILARITY In the C-terminal section; belongs to the eukaryotic ribosomal protein eL40 family.UniProtP6298777EQUAL128EQUALReactome DB_ID: 724401UniProt:P61353 RPL27RPL27RPL27FUNCTION Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:25957688, PubMed:25901680). Required for proper rRNA processing and maturation of 28S and 5.8S rRNAs (PubMed:25424902).SUBUNIT Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:25957688, PubMed:25901680). Interacts with RRP1B (PubMed:20926688). Interacts with DHX33 (PubMed:26100019).SIMILARITY Belongs to the eukaryotic ribosomal protein eL27 family.UniProtP613531EQUAL136EQUALReactome DB_ID: 724081UniProt:P30050 RPL12RPL12RPL12FUNCTION Binds directly to 26S ribosomal RNA.SIMILARITY Belongs to the universal ribosomal protein uL11 family.UniProtP300501EQUAL165EQUALReactome DB_ID: 724321UniProt:P62750 RPL23ARPL23ARPL23AFUNCTION Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Binds a specific region on the 26S rRNA. May promote p53/TP53 degradation possibly through the stimulation of MDM2-mediated TP53 polyubiquitination (PubMed:26203195).SUBUNIT Interacts with LYAR and GNL2 (PubMed:26203195). Interacts with MDM2; this interaction may promote MDM2-mediated p53/TP53 polyubiquitination (PubMed:26203195).INDUCTION May be down-regulated by GNL2 (at protein level).PTM N-terminus is methylated by METTL11A/NTM1.PTM Citrullinated by PADI4.SIMILARITY Belongs to the universal ribosomal protein uL23 family.UniProtP627502EQUAL156EQUALReactome DB_ID: 724121UniProt:P40429 RPL13ARPL13ARPL13AFUNCTION Associated with ribosomes but is not required for canonical ribosome function and has extra-ribosomal functions. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation and subsequent phosphorylation dissociates from the ribosome and assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation. In the GAIT complex interacts with m7G cap-bound eIF4G at or near the eIF3-binding site and blocks the recruitment of the 43S ribosomal complex. Involved in methylation of rRNA.SUBUNIT Component of the 60S ribosome. Component of the GAIT complex. Interacts with EIF4G1.PTM Phosphorylation at Ser-77 upon interferon-gamma treatment in monocytes involves a DAPK1-DAPK3 kinase cascade and is causing release from the ribosome, association with the GAIT complex and subsequent involvement in transcript-selective translation inhibition.PTM Citrullinated by PADI4.SIMILARITY Belongs to the universal ribosomal protein uL13 family.UniProtP404292EQUAL203EQUALReactome DB_ID: 724421UniProt:P46776 RPL27ARPL27ARPL27APTM Hydroxylated on His-39 by MINA.SIMILARITY Belongs to the universal ribosomal protein uL15 family.UniProtP467762EQUAL148EQUALReactome DB_ID: 724181UniProt:P18621 RPL17RPL17RPL17FUNCTION Component of the large ribosomal subunit.SUBUNIT Component of the large ribosomal subunit.TISSUE SPECIFICITY Expressed in pancreas, lung, colon, cystic duct, gall bladder, kidney and liver. Expressed at high levels in the well differentiated pancreatic tumor cell lines HPAF, COLO 357 and Capan-1, the moderately differentiated pancreatic tumor cell lines T3M-4, AsPc-1 and BxPc-3, the poorly differentiated pancreatic tumor cell line MIA PaCa-2, and the pancreatic tumor cell lines of undefined differentiation status such as SW979. Expressed at lower levels in the poorly differentiated pancreatic tumor cell lines HCG-25 and PANC-1.SIMILARITY Belongs to the universal ribosomal protein uL22 family.UniProtP186212EQUAL184EQUALConverted from EntitySet in ReactomeReactome DB_ID: 88688511RPL3,RPL3L [cytosol]Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntityRPL3 [cytosol]UniProtP39023Reactome DB_ID: 724841UniProt:Q02878 RPL6RPL6TXREB1RPL6FUNCTION Component of the large ribosomal subunit.FUNCTION (Microbial infection) Specifically binds to domain C of the Tax-responsive enhancer element in the long terminal repeat of HTLV-I (PubMed:8457378).SUBUNIT Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:25957688, PubMed:25901680). May bind IPO9 with low affinity (By similarity).SIMILARITY Belongs to the eukaryotic ribosomal protein eL6 family.UniProtQ028782EQUAL288EQUALConverted from EntitySet in ReactomeReactome DB_ID: 88688191RPL36A,RPL36AL [cytosol]Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntityRPL36A [cytosol]UniProtP83881Reactome DB_ID: 724521UniProt:P62888 RPL30RPL30RPL30SIMILARITY Belongs to the eukaryotic ribosomal protein eL30 family.UniProtP628881EQUAL115EQUALReactome DB_ID: 724641UniProt:Q9Y3U8 RPL36RPL36RPL36FUNCTION Component of the large ribosomal subunit.SUBUNIT Component of the large ribosomal subunit.SIMILARITY Belongs to the eukaryotic ribosomal protein eL36 family.UniProtQ9Y3U82EQUAL105EQUALReactome DB_ID: 724161UniProt:P61313 RPL15RPL15TCBAP0781RPL15EC45SUBUNIT Interacts with IFIT1 (via TPR repeats 1-4).SIMILARITY Belongs to the eukaryotic ribosomal protein eL15 family.UniProtP613131EQUAL204EQUALReactome DB_ID: 724861UniProt:P18124 RPL7RPL7RPL7FUNCTION Component of the large ribosomal subunit (PubMed:12962325). Binds to G-rich structures in 28S rRNA and in mRNAs. Plays a regulatory role in the translation apparatus; inhibits cell-free translation of mRNAs.SUBUNIT Component of the large ribosomal subunit (Probable). Homodimer. Interacts with DHX33 (PubMed:26100019).SIMILARITY Belongs to the universal ribosomal protein uL30 family.UniProtP181241EQUAL248EQUALReactome DB_ID: 724701UniProt:P63173 RPL38RPL38RPL38SIMILARITY Belongs to the eukaryotic ribosomal protein eL38 family.UniProtP631732EQUAL70EQUALReactome DB_ID: 724601UniProt:P42766 RPL35RPL35RPL35FUNCTION Component of the large ribosomal subunit.SUBUNIT Component of the large ribosomal subunit.SIMILARITY Belongs to the universal ribosomal protein uL29 family.UniProtP427662EQUAL123EQUALReactome DB_ID: 724561UniProt:P62910 RPL32RPL32RPL32PP9932SIMILARITY Belongs to the eukaryotic ribosomal protein eL32 family.UniProtP629102EQUAL135EQUALReactome DB_ID: 724981EMBL:M11167 28S rRNA28S rRNAEMBLM111671EQUAL5025EQUALReactome DB_ID: 724681UniProt:P61513 RPL37ARPL37ARPL37ASIMILARITY Belongs to the eukaryotic ribosomal protein eL43 family.UniProtP615132EQUAL92EQUALReactome DB_ID: 724741UniProt:P36578 RPL4RPL4RPL4RPL1SUBUNIT May bind IPO9 with low affinity. Interacts with RBM3 (By similarity).PTM Citrullinated by PADI4.SIMILARITY Belongs to the universal ribosomal protein uL4 family.UniProtP365782EQUAL427EQUALReactome DB_ID: 724941EMBL:V00589 5S rRNA5S rRNAEMBLV00589Reactome Database ID Release 7572499Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=72499ReactomeR-HSA-724992Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-72499.2Reactome DB_ID: 72392140S ribosomal complex [cytosol]40S ribosomal complexReactome DB_ID: 723411UniProt:P62269 RPS18RPS18RPS18D6S218EFUNCTION Located at the top of the head of the 40S subunit, it contacts several helices of the 18S rRNA.SIMILARITY Belongs to the universal ribosomal protein uS13 family.UniProtP622692EQUAL152EQUALReactome DB_ID: 723631UniProt:P62979 RPS27ARPS27AUBA80RPS27AUBCEP1SUBUNIT Ribosomal protein S27a is part of the 40S ribosomal subunit.MISCELLANEOUS Ubiquitin is encoded by 4 different genes. UBA52 and RPS27A genes code for a single copy of ubiquitin fused to the ribosomal proteins L40 and S27a, respectively. UBB and UBC genes code for a polyubiquitin precursor with exact head to tail repeats, the number of repeats differ between species and strains.MISCELLANEOUS For a better understanding, features related to ubiquitin are only indicated for the first chain.SIMILARITY In the N-terminal section; belongs to the ubiquitin family.SIMILARITY In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family.UniProtP6297977EQUAL156EQUALReactome DB_ID: 723531UniProt:P62266 RPS23RPS23RPS23FUNCTION Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:28257692, PubMed:23636399, PubMed:25957688, PubMed:25901680). The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (PubMed:23636399, PubMed:25957688, PubMed:25901680). Plays an important role in translational accuracy (PubMed:28257692).SUBUNIT Component of the 40S small ribosomal subunit.PTM Hydroxylation at Pro-62 affects translation termination efficiency.SIMILARITY Belongs to the universal ribosomal protein uS12 family.UniProtP622662EQUAL143EQUALReactome DB_ID: 723371UniProt:P62249 RPS16RPS16RPS16SIMILARITY Belongs to the universal ribosomal protein uS9 family.UniProtP622492EQUAL146EQUALReactome DB_ID: 723651UniProt:P62857 RPS28RPS28RPS28SUBUNIT Component of the 40S small ribosomal subunit.SIMILARITY Belongs to the eukaryotic ribosomal protein eS28 family.UniProtP628571EQUAL69EQUALConverted from EntitySet in ReactomeReactome DB_ID: 88688391RPS27,RPS27L [cytosol]Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntityRPS27 [cytosol]UniProtP42677Reactome DB_ID: 723511UniProt:P63220 RPS21RPS21RPS21SUBUNIT Component of the 40S small ribosomal subunit.SIMILARITY Belongs to the eukaryotic ribosomal protein eS21 family.UniProtP632201EQUAL83EQUALReactome DB_ID: 723831UniProt:P62081 RPS7RPS7RPS7FUNCTION Required for rRNA maturation.SUBUNIT Binds IPO9 with high affinity (PubMed:11823430). Interacts with NEK6 (PubMed:20873783). Interacts with DESI2 (PubMed:28483520).PTM Phosphorylated by NEK6.PTM Ubiquitinated. Deubiquitinated by DESI2, leading to its stabilization.SIMILARITY Belongs to the eukaryotic ribosomal protein eS7 family.UniProtP620811EQUAL194EQUALReactome DB_ID: 723571UniProt:P62851 RPS25RPS25RPS25SIMILARITY Belongs to the eukaryotic ribosomal protein eS25 family.UniProtP628511EQUAL125EQUALReactome DB_ID: 723331UniProt:P62263 RPS14RPS14RPS14PRO2640SIMILARITY Belongs to the universal ribosomal protein uS11 family.UniProtP622632EQUAL151EQUALReactome DB_ID: 723251UniProt:P46783 RPS10RPS10RPS10FUNCTION Component of the 40S ribosomal subunit.SUBUNIT Component of the small ribosomal subunit. Interacts with PRMT5. The methylated form interacts with NPM1.PTM Methylated by PRMT5. Methylation is necessary for its interaction with NPS1, its localization in the granular component (GC) region of the nucleolus, for the proper assembly of ribosomes, protein synthesis and optimal cell proliferation.PTM Monoubiquitinated by ZNF598 when a ribosome has stalled during translation of poly(A) sequences, leading to preclude synthesis of a long poly-lysine tail and initiate the ribosome quality control (RQC) pathway to degrade the potentially detrimental aberrant nascent polypeptide (PubMed:28065601, PubMed:28132843).SIMILARITY Belongs to the eukaryotic ribosomal protein eS10 family.UniProtP467831EQUAL165EQUALReactome DB_ID: 723691UniProt:P23396 RPS3RPS3OK/SW-cl.26RPS3FUNCTION Involved in translation as a component of the 40S small ribosomal subunit (PubMed:8706699). Has endonuclease activity and plays a role in repair of damaged DNA (PubMed:7775413). Cleaves phosphodiester bonds of DNAs containing altered bases with broad specificity and cleaves supercoiled DNA more efficiently than relaxed DNA (PubMed:15707971). Displays high binding affinity for 7,8-dihydro-8-oxoguanine (8-oxoG), a common DNA lesion caused by reactive oxygen species (ROS) (PubMed:14706345). Has also been shown to bind with similar affinity to intact and damaged DNA (PubMed:18610840). Stimulates the N-glycosylase activity of the base excision protein OGG1 (PubMed:15518571). Enhances the uracil excision activity of UNG1 (PubMed:18973764). Also stimulates the cleavage of the phosphodiester backbone by APEX1 (PubMed:18973764). When located in the mitochondrion, reduces cellular ROS levels and mitochondrial DNA damage (PubMed:23911537). Has also been shown to negatively regulate DNA repair in cells exposed to hydrogen peroxide (PubMed:17049931). Plays a role in regulating transcription as part of the NF-kappa-B p65-p50 complex where it binds to the RELA/p65 subunit, enhances binding of the complex to DNA and promotes transcription of target genes (PubMed:18045535). Represses its own translation by binding to its cognate mRNA (PubMed:20217897). Binds to and protects TP53/p53 from MDM2-mediated ubiquitination (PubMed:19656744). Involved in spindle formation and chromosome movement during mitosis by regulating microtubule polymerization (PubMed:23131551). Involved in induction of apoptosis through its role in activation of CASP8 (PubMed:14988002). Induces neuronal apoptosis by interacting with the E2F1 transcription factor and acting synergistically with it to up-regulate pro-apoptotic proteins BCL2L11/BIM and HRK/Dp5 (PubMed:20605787). Interacts with TRADD following exposure to UV radiation and induces apoptosis by caspase-dependent JNK activation (PubMed:22510408).ACTIVITY REGULATION Endonuclease activity is inhibited by MgCl2 on apurinic/apyrimidinic DNA but not on UV-irradiated DNA.SUBUNIT Component of the 40S small ribosomal subunit (PubMed:8706699). Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs (PubMed:17289661). Interacts with HNRPD (PubMed:24423872). Interacts with PRMT1; the interaction methylates RPS3 (PubMed:19460357). Interacts with SUMO1; the interaction sumoylates RPS3 (PubMed:21968017). Interacts with UBC9 (PubMed:21968017). Interacts with CDK1; the interaction phosphorylates RPS3 (PubMed:21871177). Interacts with PRKCD; the interaction phosphorylates RPS3 (PubMed:19059439). Interacts with PKB/AKT; the interaction phosphorylates RPS3 (PubMed:20605787). Interacts with E2F1; the interaction occurs in the absence of nerve growth factor and increases transcription of pro-apoptotic proteins BCL2L11/BIM and HRK/Dp5 (PubMed:20605787). Interacts with the base excision repair proteins APEX1 and OGG1; interaction with OGG1 increases OGG1 N-glycosylase activity (PubMed:15518571). Interacts with UNG; the interaction increases the uracil excision activity of UNG1 (PubMed:18973764). Interacts with HSP90; the interaction prevents the ubiquitination and proteasome-dependent degradation of RPS3 and is suppressed by increased ROS levels (PubMed:16314389). Interacts with TOM70; the interaction promotes translocation of RPS3 to the mitochondrion (PubMed:23911537). Interacts (via N-terminus) with RELA (via N-terminus); the interaction enhances the DNA-binding activity of the NF-kappa-B p65-p50 complex (PubMed:18045535). Interacts with NFKBIA; the interaction is direct and may bridge the interaction between RPS3 and RELA (PubMed:24457201). Interacts with IKKB; the interaction phosphorylates RPS3 and enhances its translocation to the nucleus (PubMed:21399639). Interacts (via KH domain) with MDM2 and TP53 (PubMed:19656744). Interacts with TRADD (PubMed:22510408). Interacts (via N-terminus) with E.coli O157:H7 (strain EDL933) nleH1 and nleH2; the interaction with nleH1 inhibits phosphorylation by IKKB, reduces RPS3 nuclear abundance and inhibits transcriptional activation by the NF-kappa-B p65-p50 complex (PubMed:20041225, PubMed:21399639). Identified in a HCV IRES-mediated translation complex, at least composed of EIF3C, IGF2BP1, RPS3 and HCV RNA-replicon (PubMed:19541769). Interacts with CRY1 (By similarity).PTM Methylation by PRMT1 is required for import into the nucleolus and for ribosome assembly.PTM Sumoylation by SUMO1 enhances protein stability through increased resistance to proteolysis. Sumoylation occurs at one or more of the three consensus sites, Lys-18, Lys-214 and Lys-230.PTM Phosphorylation at Thr-221 by CDK1 occurs mainly in G2/M phase (PubMed:21871177). Phosphorylation by PRKCD occurs on a non-ribosomal-associated form which results in translocation of RPS3 to the nucleus and enhances its endonuclease activity (PubMed:19059439). Phosphorylated on Ser-209 by IKKB in response to activation of the NF-kappa-B p65-p50 complex which enhances the association of RPS3 with importin-alpha and mediates the nuclear translocation of RPS3 (PubMed:21399639). Phosphorylation by MAPK is required for translocation to the nucleus following exposure of cells to DNA damaging agents such as hydrogen peroxide (PubMed:17560175). Phosphorylation by PKB/AKT mediates RPS3 nuclear translocation, enhances RPS3 endonuclease activity and suppresses RPS3-induced neuronal apoptosis (PubMed:20605787).PTM Ubiquitinated (PubMed:16314389). This is prevented by interaction with HSP90 which stabilizes the protein (PubMed:16314389). Monoubiquitinated at Lys-214 by ZNF598 when a ribosome has stalled during translation of poly(A) sequences, leading to preclude synthesis of a long poly-lysine tail and initiate the ribosome quality control (RQC) pathway to degrade the potentially detrimental aberrant nascent polypeptide (PubMed:28065601, PubMed:28132843).PTM Ufmylated by UFL1.SIMILARITY Belongs to the universal ribosomal protein uS3 family.UniProtP233962EQUAL243EQUALReactome DB_ID: 723351UniProt:P62841 RPS15RPS15RPS15RIGSIMILARITY Belongs to the universal ribosomal protein uS19 family.UniProtP628412EQUAL145EQUALReactome DB_ID: 723491UniProt:P60866 RPS20RPS20RPS20SUBUNIT Component of the 40S small ribosomal subunit.PTM Monoubiquitinated by ZNF598 when a ribosome has stalled during translation of poly(A) sequences, leading to preclude synthesis of a long poly-lysine tail and initiate the ribosome quality control (RQC) pathway to degrade the potentially detrimental aberrant nascent polypeptide (PubMed:28065601, PubMed:28132843).PTM Ufmylated by UFL1.SIMILARITY Belongs to the universal ribosomal protein uS10 family.UniProtP608662EQUAL119EQUALReactome DB_ID: 723911EMBL:X03205 18S rRNA18S rRNAEMBLX03205Reactome DB_ID: 723891UniProt:P08865 RPSARPSALAMBRRPSALAMR1FUNCTION Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Acts as a PPP1R16B-dependent substrate of PPP1CA.FUNCTION (Microbial infection) Acts as a receptor for the Adeno-associated viruses 2,3,8 and 9.FUNCTION (Microbial infection) Acts as a receptor for the Dengue virus.FUNCTION (Microbial infection) Acts as a receptor for the Sindbis virus.FUNCTION (Microbial infection) Acts as a receptor for the Venezuelan equine encephalitis virus.FUNCTION (Microbial infection) Acts as a receptor for the pathogenic prion protein.FUNCTION (Microbial infection) Acts as a receptor for bacteria.SUBUNIT Monomer (37LRP) and homodimer (67LR). Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Interacts with RPS21. Interacts with several laminins including at least LAMB1. Interacts with MDK (By similarity). The mature dimeric form interacts with PPP1R16B (via its fourth ankyrin repeat). Interacts with PPP1CA only in the presence of PPP1R16B.SUBUNIT (Microbial infection) 67LR interacts with capsid protein of Adeno-associated virus 2,3,8 and 9.SUBUNIT (Microbial infection) 67LR interacts with envelope protein of dengue virus.SUBUNIT (Microbial infection) 6s7LR interacts with E2 glycoprotein of Sindbis and Venezuelan equine encephalitis virus (PubMed:8764073, PubMed:1385835).PTM Acylated. Acylation may be a prerequisite for conversion of the monomeric 37 kDa laminin receptor precursor (37LRP) to the mature dimeric 67 kDa laminin receptor (67LR), and may provide a mechanism for membrane association (PubMed:9581863).PTM Cleaved by stromelysin-3 (ST3) at the cell surface. Cleavage by stromelysin-3 may be a mechanism to alter cell-extracellular matrix interactions.MISCELLANEOUS This protein appears to have acquired a second function as a laminin receptor specifically in the vertebrate lineage.MISCELLANEOUS It is thought that in vertebrates 37/67 kDa laminin receptor acquired a dual function during evolution. It developed from the ribosomal protein SA, playing an essential role in the protein biosynthesis lacking any laminin binding activity, to a cell surface receptor with laminin binding activity.SIMILARITY Belongs to the universal ribosomal protein uS2 family.UniProtP088652EQUAL295EQUALReactome DB_ID: 723291UniProt:P25398 RPS12RPS12RPS12SIMILARITY Belongs to the eukaryotic ribosomal protein eS12 family.UniProtP253982EQUAL132EQUALReactome DB_ID: 723551UniProt:P62847 RPS24RPS24RPS24FUNCTION Required for processing of pre-rRNA and maturation of 40S ribosomal subunits.TISSUE SPECIFICITY Mature tissues, such as adult brain, skeletal muscle, heart, and kidney, express low levels, whereas tissues and organs with significant populations of proliferating cells, such as fetal brain, placenta, bone marrow, and various glandular organs, contain significantly higher levels.SIMILARITY Belongs to the eukaryotic ribosomal protein eS24 family.UniProtP628471EQUAL133EQUALReactome DB_ID: 723731UniProt:P61247 RPS3ARPS3AMFTLRPS3AFTE1FUNCTION May play a role during erythropoiesis through regulation of transcription factor DDIT3.SUBUNIT Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Binds with high affinity to IPO4. Interacts with DDIT3.SIMILARITY Belongs to the eukaryotic ribosomal protein eS1 family.UniProtP612472EQUAL264EQUALConverted from EntitySet in ReactomeReactome DB_ID: 88688321RPS4X,RPS4Y1,RPS4Y2 [cytosol]Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntityRPS4Y1 [cytosol]RPS4X [cytosol]UniProtP22090UniProtP62701Reactome DB_ID: 723671UniProt:P62273 RPS29RPS29RPS29SUBUNIT Component of the 40S small ribosomal subunit.SIMILARITY Belongs to the universal ribosomal protein uS14 family.UniProtP622732EQUAL56EQUALReactome DB_ID: 723871UniProt:P46781 RPS9RPS9RPS9SUBUNIT Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs.SIMILARITY Belongs to the universal ribosomal protein uS4 family.UniProtP467812EQUAL194EQUALReactome DB_ID: 723811UniProt:P62753 RPS6RPS6OK/SW-cl.2RPS6FUNCTION May play an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA.PTM Ribosomal protein S6 is the major substrate of protein kinases in eukaryote ribosomes. The phosphorylation is stimulated by growth factors, tumor promoting agents, and mitogens. It is dephosphorylated at growth arrest. Phosphorylated at Ser-235 and Ser-236 by RPS6KA1 and RPS6KA3; phosphorylation at these sites facilitates the assembly of the preinitiation complex.PTM Specifically hydroxylated (with R stereochemistry) at C-3 of Arg-137 by KDM8.SIMILARITY Belongs to the eukaryotic ribosomal protein eS6 family.UniProtP627531EQUAL249EQUALReactome DB_ID: 723471UniProt:P15880 RPS2RPS2RPS4RPS2PTM Citrullinated by PADI4 in the Arg/Gly-rich region.PTM Asymmetric arginine dimethylation by PRMT3 occurs at multiple sites in the Arg/Gly-rich region.SIMILARITY Belongs to the universal ribosomal protein uS5 family.UniProtP158801EQUAL293EQUALReactome DB_ID: 723391UniProt:P08708 RPS17RPS17RPS17RPS17LSIMILARITY Belongs to the eukaryotic ribosomal protein eS17 family.UniProtP087082EQUAL135EQUALReactome DB_ID: 723451UniProt:P62244 RPS15ARPS15ARPS15AOK/SW-cl.82FUNCTION Structural component of the ribosome (PubMed:23636399). Required for proper erythropoiesis (PubMed:27909223).SUBUNIT Component of the 40S ribosomal subunit.SIMILARITY Belongs to the universal ribosomal protein uS8 family.UniProtP622442EQUAL130EQUALReactome DB_ID: 723431UniProt:P39019 RPS19RPS19RPS19FUNCTION Required for pre-rRNA processing and maturation of 40S ribosomal subunits.SUBUNIT Interacts with RPS19BP1.TISSUE SPECIFICITY Higher level expression is seen in the colon carcinoma tissue than normal colon tissue.SIMILARITY Belongs to the eukaryotic ribosomal protein eS19 family.UniProtP390192EQUAL145EQUALReactome DB_ID: 723791UniProt:P46782 RPS5RPS5RPS5SIMILARITY Belongs to the universal ribosomal protein uS7 family.UniProtP467821EQUAL204EQUALReactome DB_ID: 723271UniProt:P62280 RPS11RPS11RPS11PTM Citrullinated by PADI4.SIMILARITY Belongs to the universal ribosomal protein uS17 family.UniProtP622802EQUAL158EQUALReactome DB_ID: 723591UniProt:P62854 RPS26RPS26RPS26SUBUNIT Component of the 40S small ribosomal subunit.SIMILARITY Belongs to the eukaryotic ribosomal protein eS26 family.UniProtP628542EQUAL115EQUALReactome DB_ID: 723311UniProt:P62277 RPS13RPS13RPS13SIMILARITY Belongs to the universal ribosomal protein uS15 family.UniProtP622772EQUAL151EQUALReactome DB_ID: 723711UniProt:P62861 FAUFAUFAUMISCELLANEOUS This ribosomal protein is synthesized as a C-terminal extension protein (CEP) of a ubiquitin-like protein.SIMILARITY Belongs to the eukaryotic ribosomal protein eS30 family.UniProtP628611EQUAL59EQUALReactome DB_ID: 723851UniProt:P62241 RPS8RPS8RPS8OK/SW-cl.83SUBUNIT Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs.SIMILARITY Belongs to the eukaryotic ribosomal protein eS8 family.UniProtP622412EQUAL208EQUALReactome Database ID Release 7572392Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=72392ReactomeR-HSA-723922Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-72392.2Reactome Database ID Release 7572500Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=72500ReactomeR-HSA-725001Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-72500.1Reactome DB_ID: 723231mRNA [cytosol]mRNAmessenger RNAReactome Database ID Release 7572505Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=72505ReactomeR-HSA-725051Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-72505.1Reactome DB_ID: 5359044180S:Met-tRNAi:mRNA:SECISBP2:Sec-tRNA(Sec):EEFSEC:GTP [cytosol]80S:Met-tRNAi:mRNA:SECISBP2:Sec-tRNA(Sec):EEFSEC:GTPReactome DB_ID: 53590361Reactome DB_ID: 535771511EQUAL854EQUALReactome DB_ID: 725051Reactome Database ID Release 755359044Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5359044ReactomeR-HSA-53590441Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5359044.1Reactome Database ID Release 752408529Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2408529ReactomeR-HSA-24085291Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-2408529.115821744Pubmed2005Ribosomal protein L30 is a component of the UGA-selenocysteine recoding machinery in eukaryotesChavatte, LaurentBrown, Bernard ADriscoll, Donna MNat. Struct. Mol. Biol. 12:408-16