BioPAX pathway converted from "Sec-tRNA(Sec):EEFSEC:GTP binds to 80S Ribosome" in the Reactome database.Sec-tRNA(Sec):EEFSEC:GTP binds to 80S Ribosome

Sec-tRNA(Sec):EEFSEC:GTP binds to 80S Ribosome

The complex consisting of selenocysteinyl (Sec) transfer RNA (tRNA) for Sec (Sec-tRNASec), selenocysteine-specific elongation factor (EEFSEC) aka SelB, selenocysteine insertion sequence-binding protein 2 (SECISBP2) aka SBP2 and GTP interacts with the 80S ribosomal protein complex (80S:Met-tRNAi:mRNA). This reaction is inferred from events occurring in rats.

Authored: Williams, MG, 2014-05-06Reviewed: Rush, MG, 2015-08-30Edited: D'Eustachio, Peter, 2015-08-29

Reactome DB_ID: 5359036

cytosolGO0005829Sec-tRNA(Sec):EEFSEC:GTP [cytosol]

Sec-tRNA(Sec):EEFSEC:GTP

Reactome DB_ID: 29438

GTP [ChEBI:15996]

GTP

Guanosine 5'-triphosphate

Reactomehttp://www.reactome.orgChEBI15996

Reactome DB_ID: 5357671

UniProt:P57772 EEFSEC

EEFSEC

EEFSECSELBFUNCTION Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP.SIMILARITY Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. SelB subfamily.

Homo sapiens

NCBI Taxonomy9606UniProtP57772

Chain Coordinates

EQUAL

596

EQUAL

Reactome DB_ID: 5357708

Sec-tRNA(Sec) [cytosol]

Sec-tRNA(Sec)

Reactome Database ID Release 725359036Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5359036ReactomeR-HSA-5359036

Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5359036.1

Reactome DB_ID: 72505

80S:Met-tRNAi:mRNA [cytosol]

80S:Met-tRNAi:mRNA

Reactome DB_ID: 72500

80S ribosome [cytosol]

80S ribosome

80S monosome

Reactome DB_ID: 72499

60S ribosomal complex [cytosol]

60S ribosomal complex

Reactome DB_ID: 72460

UniProt:P42766 RPL35

RPL35

RPL35FUNCTION Component of the large ribosomal subunit.SUBUNIT Component of the large ribosomal subunit.SIMILARITY Belongs to the universal ribosomal protein uL29 family.

UniProtP42766

EQUAL

123

EQUAL

Reactome DB_ID: 72440

UniProt:P61353 RPL27

RPL27

RPL27FUNCTION Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:25957688, PubMed:25901680). Required for proper rRNA processing and maturation of 28S and 5.8S rRNAs (PubMed:25424902).SUBUNIT Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:25957688, PubMed:25901680). Interacts with RRP1B (PubMed:20926688). Interacts with DHX33 (PubMed:26100019).SIMILARITY Belongs to the eukaryotic ribosomal protein eL27 family.

UniProtP61353

EQUAL

136

EQUAL

Reactome DB_ID: 72462

UniProt:P18077 RPL35A

RPL35A

RPL35AGIG33FUNCTION Required for the proliferation and viability of hematopoietic cells. Plays a role in 60S ribosomal subunit formation. The protein was found to bind to both initiator and elongator tRNAs and consequently was assigned to the P site or P and A site.MISCELLANEOUS Knockdown of RPL35A in hematopoietic cell lines results in decreased cell proliferation, increased apoptosis, decreased biogenesis of mature 60S ribosomal subunit, and abnormal processing of large ribosomal subunit rRNA.SIMILARITY Belongs to the eukaryotic ribosomal protein eL33 family.

UniProtP18077

EQUAL

110

EQUAL

Reactome DB_ID: 72404

UniProt:P62906 RPL10A

RPL10A

NEDD6RPL10AFUNCTION Component of the large ribosomal subunit.SUBUNIT Component of the large ribosomal subunit.SIMILARITY Belongs to the universal ribosomal protein uL1 family.

UniProtP62906

EQUAL

217

EQUAL

Reactome DB_ID: 72494

EMBL:V00589 5S rRNA5S rRNA

EMBLV00589

Reactome DB_ID: 72414

UniProt:P50914 RPL14

RPL14

RPL14FUNCTION Component of the large ribosomal subunit.SUBUNIT Component of the large ribosomal subunit.POLYMORPHISM The poly-Ala stretch is highly polymorphic.SIMILARITY Belongs to the eukaryotic ribosomal protein eL14 family.

UniProtP50914

EQUAL

215

EQUAL

Reactome DB_ID: 72426

UniProt:P46778 RPL21

RPL21

RPL21FUNCTION Component of the large ribosomal subunit.SUBUNIT Component of the large ribosomal subunit.SIMILARITY Belongs to the eukaryotic ribosomal protein eL21 family.

UniProtP46778

EQUAL

160

EQUAL

Reactome DB_ID: 72492

UniProt:P32969 RPL9

RPL9

OK/SW-cl.103RPL9P7RPL9P8RPL9P9RPL9SIMILARITY Belongs to the universal ribosomal protein uL6 family.

UniProtP32969

EQUAL

192

EQUAL

Converted from EntitySet in Reactome

Reactome DB_ID: 8868812

RPL39,RPL39L [cytosol]Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntityRPL39 [cytosol]

UniProtP62891

Reactome DB_ID: 72396

UniProt:P05388 RPLP0

RPLP0

RPLP0FUNCTION Ribosomal protein P0 is the functional equivalent of E.coli protein L10.SUBUNIT P0 forms a pentameric complex by interaction with dimers of P1 and P2 (PubMed:3323886). Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs (PubMed:17289661). Interacts with APEX1 (PubMed:19188445). Interacts with FMR1 isoform 6 (PubMed:24658146).SIMILARITY Belongs to the universal ribosomal protein uL10 family.

UniProtP05388

EQUAL

317

EQUAL

Reactome DB_ID: 72458

UniProt:P49207 RPL34

RPL34

RPL34FUNCTION Component of the large ribosomal subunit.SUBUNIT Component of the large ribosomal subunit.SIMILARITY Belongs to the eukaryotic ribosomal protein eL34 family.

UniProtP49207

EQUAL

117

EQUAL

Reactome DB_ID: 72454

UniProt:P62899 RPL31

RPL31

RPL31SIMILARITY Belongs to the eukaryotic ribosomal protein eL31 family.

UniProtP62899

EQUAL

125

EQUAL

Reactome DB_ID: 72496

EMBL:J01866 5.8S rRNA5.8S rRNA

EMBLJ01866

Reactome DB_ID: 72446

UniProt:P47914 RPL29

RPL29

RPL29FUNCTION Component of the large ribosomal subunit.SUBUNIT Component of the large ribosomal subunit.SIMILARITY Belongs to the eukaryotic ribosomal protein eL29 family.

UniProtP47914

EQUAL

159

EQUAL

Reactome DB_ID: 72422

UniProt:Q02543 RPL18A

RPL18A

RPL18ASUBUNIT Binds IPO9 with high affinity.SIMILARITY Belongs to the eukaryotic ribosomal protein eL20 family.

UniProtQ02543

EQUAL

176

EQUAL

Reactome DB_ID: 72488

UniProt:P62424 RPL7A

RPL7A

RPL7ASURF3SURF-3SUBUNIT Interacts with CRY1 (By similarity). Interacts with DICER1, AGO2, TARBP2, MOV10 and EIF6; they form a large RNA-induced silencing complex (RISC) (PubMed:17507929).DISEASE Chromosomal recombination involving RPL7A activates the receptor kinase domain of the TRK oncogene.SIMILARITY Belongs to the eukaryotic ribosomal protein eL8 family.

UniProtP62424

EQUAL

266

EQUAL

Converted from EntitySet in Reactome

Reactome DB_ID: 8868819

RPL36A,RPL36AL [cytosol]Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntityRPL36A [cytosol]

UniProtP83881

Reactome DB_ID: 72452

UniProt:P62888 RPL30

RPL30

RPL30SIMILARITY Belongs to the eukaryotic ribosomal protein eL30 family.

UniProtP62888

EQUAL

115

EQUAL

Reactome DB_ID: 72470

UniProt:P63173 RPL38

RPL38

RPL38SIMILARITY Belongs to the eukaryotic ribosomal protein eL38 family.

UniProtP63173

EQUAL

Reactome DB_ID: 72410

UniProt:P26373 RPL13

RPL13

BBC1OK/SW-cl.46RPL13TISSUE SPECIFICITY Higher levels of expression in benign breast lesions than in carcinomas.SIMILARITY Belongs to the eukaryotic ribosomal protein eL13 family.

UniProtP26373

EQUAL

211

EQUAL

Reactome DB_ID: 72444

UniProt:P46779 RPL28

RPL28

RPL28FUNCTION Component of the large ribosomal subunit.SUBUNIT Component of the large ribosomal subunit.SIMILARITY Belongs to the eukaryotic ribosomal protein eL28 family.

UniProtP46779

EQUAL

137

EQUAL

Reactome DB_ID: 72476

UniProt:P62987 UBA52

UBA52

UBCEP2UBA52SUBUNIT Ribosomal protein L40 is part of the 60S ribosomal subunit. Interacts with UBQLN1 (via UBA domain).MISCELLANEOUS Ubiquitin is encoded by 4 different genes. UBA52 and RPS27A genes code for a single copy of ubiquitin fused to the ribosomal proteins L40 and S27a, respectively. UBB and UBC genes code for a polyubiquitin precursor with exact head to tail repeats, the number of repeats differ between species and strains.MISCELLANEOUS For a better understanding, features related to ubiquitin are only indicated for the first chain.SIMILARITY In the N-terminal section; belongs to the ubiquitin family.SIMILARITY In the C-terminal section; belongs to the eukaryotic ribosomal protein eL40 family.

UniProtP62987

EQUAL

128

EQUAL

Reactome DB_ID: 72486

UniProt:P18124 RPL7

RPL7

RPL7FUNCTION Component of the large ribosomal subunit (PubMed:12962325). Binds to G-rich structures in 28S rRNA and in mRNAs. Plays a regulatory role in the translation apparatus; inhibits cell-free translation of mRNAs.SUBUNIT Component of the large ribosomal subunit (Probable). Homodimer. Interacts with DHX33 (PubMed:26100019).SIMILARITY Belongs to the universal ribosomal protein uL30 family.

UniProtP18124

EQUAL

248

EQUAL

Converted from EntitySet in Reactome

Reactome DB_ID: 8868847

RPL22,RPL22L1 [cytosol]Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntityRPL22 [cytosol]

UniProtP35268

Reactome DB_ID: 72416

UniProt:P61313 RPL15

RPL15

TCBAP0781RPL15EC45SUBUNIT Interacts with IFIT1 (via TPR repeats 1-4).SIMILARITY Belongs to the eukaryotic ribosomal protein eL15 family.

UniProtP61313

EQUAL

204

EQUAL

Reactome DB_ID: 72412

UniProt:P40429 RPL13A

RPL13A

RPL13AFUNCTION Associated with ribosomes but is not required for canonical ribosome function and has extra-ribosomal functions. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation and subsequent phosphorylation dissociates from the ribosome and assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation. In the GAIT complex interacts with m7G cap-bound eIF4G at or near the eIF3-binding site and blocks the recruitment of the 43S ribosomal complex. Involved in methylation of rRNA.SUBUNIT Component of the 60S ribosome. Component of the GAIT complex. Interacts with EIF4G1.PTM Phosphorylation at Ser-77 upon interferon-gamma treatment in monocytes involves a DAPK1-DAPK3 kinase cascade and is causing release from the ribosome, association with the GAIT complex and subsequent involvement in transcript-selective translation inhibition.PTM Citrullinated by PADI4.SIMILARITY Belongs to the universal ribosomal protein uL13 family.

UniProtP40429

EQUAL

203

EQUAL

Reactome DB_ID: 72498

EMBL:M11167 28S rRNA28S rRNA

EMBLM11167

EQUAL

5025

EQUAL

Reactome DB_ID: 72420

UniProt:Q07020 RPL18

RPL18

RPL18FUNCTION Component of the large ribosomal subunit.SUBUNIT Component of the large ribosomal subunit.SIMILARITY Belongs to the eukaryotic ribosomal protein eL18 family.

UniProtQ07020

EQUAL

188

EQUAL

Reactome DB_ID: 72456

UniProt:P62910 RPL32

RPL32

RPL32PP9932SIMILARITY Belongs to the eukaryotic ribosomal protein eL32 family.

UniProtP62910

EQUAL

135

EQUAL

Reactome DB_ID: 72464

UniProt:Q9Y3U8 RPL36

RPL36

RPL36FUNCTION Component of the large ribosomal subunit.SUBUNIT Component of the large ribosomal subunit.SIMILARITY Belongs to the eukaryotic ribosomal protein eL36 family.

UniProtQ9Y3U8

EQUAL

105

EQUAL

Reactome DB_ID: 72406

UniProt:P62913 RPL11

RPL11

RPL11FUNCTION Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. As part of the 5S RNP/5S ribonucleoprotein particle it is an essential component of the LSU, required for its formation and the maturation of rRNAs (PubMed:19061985, PubMed:12962325, PubMed:24120868). It also couples ribosome biogenesis to p53/TP53 activation. As part of the 5S RNP it accumulates in the nucleoplasm and inhibits MDM2, when ribosome biogenesis is perturbed, mediating the stabilization and the activation of TP53 (PubMed:24120868). Promotes nucleolar location of PML (By similarity).SUBUNIT Component of the large ribosomal subunit (LSU). Part of a LSU subcomplex, the 5S RNP which is composed of the 5S RNA, RPL5 and RPL11 (PubMed:24120868). Interacts with PML (By similarity). Interacts with MDM2; negatively regulates MDM2-mediated TP53 ubiquitination and degradation (PubMed:24120868). Interacts with NOP53; retains RPL11 into the nucleolus (PubMed:24556985, PubMed:27829214).SIMILARITY Belongs to the universal ribosomal protein uL5 family.

UniProtP62913

EQUAL

178

EQUAL

Reactome DB_ID: 72482

UniProt:P46777 RPL5

RPL5

RPL5MSTP030FUNCTION Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. As part of the 5S RNP/5S ribonucleoprotein particle it is an essential component of the LSU, required for its formation and the maturation of rRNAs (PubMed:12962325, PubMed:19061985, PubMed:24120868, PubMed:23636399). It also couples ribosome biogenesis to p53/TP53 activation. As part of the 5S RNP it accumulates in the nucleoplasm and inhibits MDM2, when ribosome biogenesis is perturbed, mediating the stabilization and the activation of TP53 (PubMed:24120868).SUBUNIT Component of the large ribosomal subunit (LSU). Part of a LSU subcomplex, the 5S RNP which is composed of the 5S RNA, RPL5 and RPL11 (PubMed:24120868). Interacts with isoform 1 of NVL in an ATP-dependent manner (PubMed:15469983). Interacts with RRP1B (PubMed:20926688).SIMILARITY Belongs to the universal ribosomal protein uL18 family.

UniProtP46777

EQUAL

297

EQUAL

Reactome DB_ID: 72408

UniProt:P30050 RPL12

RPL12

RPL12FUNCTION Binds directly to 26S ribosomal RNA.SIMILARITY Belongs to the universal ribosomal protein uL11 family.

UniProtP30050

EQUAL

165

EQUAL

Converted from EntitySet in Reactome

Reactome DB_ID: 8868827

RPL26,RPL26L1 [cytosol]Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntityRPL26 [cytosol]

UniProtP61254

Reactome DB_ID: 72424

UniProt:P84098 RPL19

RPL19

RPL19PTM Citrullinated by PADI4.SIMILARITY Belongs to the eukaryotic ribosomal protein eL19 family.

UniProtP84098

EQUAL

196

EQUAL

Converted from EntitySet in Reactome

Reactome DB_ID: 8868854

RPL10,RPL10L [cytosol]Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntityRPL10 [cytosol]

UniProtP27635Converted from EntitySet in Reactome

Reactome DB_ID: 8868851

RPL3,RPL3L [cytosol]Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntityRPL3 [cytosol]

UniProtP39023

Reactome DB_ID: 72478

UniProt:P62945 RPL41

RPL41

RPL41FUNCTION Interacts with the beta subunit of protein kinase CKII and stimulates phosphorylation of DNA topoisomerase II alpha by CKII.SIMILARITY Belongs to the eukaryotic ribosomal protein eL41 family.CAUTION There are multiple pseudogenes of this gene dispersed through the genome.

UniProtP62945

EQUAL

Reactome DB_ID: 72434

UniProt:P83731 RPL24

RPL24

RPL24SIMILARITY Belongs to the eukaryotic ribosomal protein eL24 family.

UniProtP83731

EQUAL

157

EQUAL

Reactome DB_ID: 72466

UniProt:P61927 RPL37

RPL37

RPL37FUNCTION Binds to the 23S rRNA.SIMILARITY Belongs to the eukaryotic ribosomal protein eL37 family.

UniProtP61927

EQUAL

Reactome DB_ID: 72400

UniProt:P05387 RPLP2

RPLP2

D11S2243ERPP2RPLP2FUNCTION Plays an important role in the elongation step of protein synthesis.SUBUNIT Heterodimer with RPLP1 at the lateral ribosomal stalk of the large ribosomal subunit.SIMILARITY Belongs to the eukaryotic ribosomal protein P1/P2 family.

UniProtP05387

EQUAL

115

EQUAL

Reactome DB_ID: 72468

UniProt:P61513 RPL37A

RPL37A

RPL37ASIMILARITY Belongs to the eukaryotic ribosomal protein eL43 family.

UniProtP61513

EQUAL

Reactome DB_ID: 72418

UniProt:P18621 RPL17

RPL17

RPL17FUNCTION Component of the large ribosomal subunit.SUBUNIT Component of the large ribosomal subunit.TISSUE SPECIFICITY Expressed in pancreas, lung, colon, cystic duct, gall bladder, kidney and liver. Expressed at high levels in the well differentiated pancreatic tumor cell lines HPAF, COLO 357 and Capan-1, the moderately differentiated pancreatic tumor cell lines T3M-4, AsPc-1 and BxPc-3, the poorly differentiated pancreatic tumor cell line MIA PaCa-2, and the pancreatic tumor cell lines of undefined differentiation status such as SW979. Expressed at lower levels in the poorly differentiated pancreatic tumor cell lines HCG-25 and PANC-1.SIMILARITY Belongs to the universal ribosomal protein uL22 family.

UniProtP18621

EQUAL

184

EQUAL

Reactome DB_ID: 72442

UniProt:P46776 RPL27A

RPL27A

RPL27APTM Hydroxylated on His-39 by MINA.SIMILARITY Belongs to the universal ribosomal protein uL15 family.

UniProtP46776

EQUAL

148

EQUAL

Reactome DB_ID: 72484

UniProt:Q02878 RPL6

RPL6

TXREB1RPL6FUNCTION Component of the large ribosomal subunit.FUNCTION (Microbial infection) Specifically binds to domain C of the Tax-responsive enhancer element in the long terminal repeat of HTLV-I (PubMed:8457378).SUBUNIT Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:25957688, PubMed:25901680). May bind IPO9 with low affinity (By similarity).SIMILARITY Belongs to the eukaryotic ribosomal protein eL6 family.

UniProtQ02878

EQUAL

288

EQUAL

Reactome DB_ID: 72432

UniProt:P62750 RPL23A

RPL23A

RPL23AFUNCTION Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Binds a specific region on the 26S rRNA. May promote p53/TP53 degradation possibly through the stimulation of MDM2-mediated TP53 polyubiquitination (PubMed:26203195).SUBUNIT Interacts with LYAR and GNL2 (PubMed:26203195). Interacts with MDM2; this interaction may promote MDM2-mediated p53/TP53 polyubiquitination (PubMed:26203195).INDUCTION May be down-regulated by GNL2 (at protein level).PTM N-terminus is methylated by METTL11A/NTM1.PTM Citrullinated by PADI4.SIMILARITY Belongs to the universal ribosomal protein uL23 family.

UniProtP62750

EQUAL

156

EQUAL

Reactome DB_ID: 72398

UniProt:P05386 RPLP1

RPLP1

RPLP1RRP1FUNCTION Plays an important role in the elongation step of protein synthesis.SUBUNIT Heterodimer with RPLP2 at the lateral ribosomal stalk of the large ribosomal subunit.SIMILARITY Belongs to the eukaryotic ribosomal protein P1/P2 family.

UniProtP05386

EQUAL

114

EQUAL

Reactome DB_ID: 72474

UniProt:P36578 RPL4

RPL4

RPL4RPL1SUBUNIT May bind IPO9 with low affinity. Interacts with RBM3 (By similarity).PTM Citrullinated by PADI4.SIMILARITY Belongs to the universal ribosomal protein uL4 family.

UniProtP36578

EQUAL

427

EQUAL

Reactome DB_ID: 72430

UniProt:P62829 RPL23

RPL23

RPL23SIMILARITY Belongs to the universal ribosomal protein uL14 family.

UniProtP62829

EQUAL

140

EQUAL

Reactome DB_ID: 72490

UniProt:P62917 RPL8

RPL8

RPL8FUNCTION Component of the large ribosomal subunit.SUBUNIT Component of the large ribosomal subunit (Probable). Interacts with CRY1 (By similarity).PTM Hydroxylated on His-216 by RIOX1. The modification is impaired by hypoxia.MISCELLANEOUS This protein can be partially incorporated into E.coli polysomes in vivo, indicating it can replace the endogenous protein.SIMILARITY Belongs to the universal ribosomal protein uL2 family.

UniProtP62917

EQUAL

257

EQUAL

Reactome Database ID Release 7272499Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=72499ReactomeR-HSA-72499

Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-72499.2

Reactome DB_ID: 72392

40S ribosomal complex [cytosol]

40S ribosomal complex

Reactome DB_ID: 72349

UniProt:P60866 RPS20

RPS20

RPS20SUBUNIT Component of the 40S small ribosomal subunit.PTM Monoubiquitinated by ZNF598 when a ribosome has stalled during translation of poly(A) sequences, leading to preclude synthesis of a long poly-lysine tail and initiate the ribosome quality control (RQC) pathway to degrade the potentially detrimental aberrant nascent polypeptide (PubMed:28065601, PubMed:28132843).SIMILARITY Belongs to the universal ribosomal protein uS10 family.

UniProtP60866

EQUAL

119

EQUAL

Reactome DB_ID: 72353

UniProt:P62266 RPS23

RPS23

RPS23FUNCTION Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:28257692, PubMed:23636399, PubMed:25957688, PubMed:25901680). The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (PubMed:23636399, PubMed:25957688, PubMed:25901680). Plays an important role in translational accuracy (PubMed:28257692).SUBUNIT Component of the 40S small ribosomal subunit.PTM Hydroxylation at Pro-62 affects translation termination efficiency.SIMILARITY Belongs to the universal ribosomal protein uS12 family.

UniProtP62266

EQUAL

143

EQUAL

Reactome DB_ID: 72329

UniProt:P25398 RPS12

RPS12

RPS12SIMILARITY Belongs to the eukaryotic ribosomal protein eS12 family.

UniProtP25398

EQUAL

132

EQUAL

Reactome DB_ID: 72351

UniProt:P63220 RPS21

RPS21

RPS21SUBUNIT Component of the 40S small ribosomal subunit.SIMILARITY Belongs to the eukaryotic ribosomal protein eS21 family.

UniProtP63220

EQUAL

Converted from EntitySet in Reactome

Reactome DB_ID: 8868832

RPS4X,RPS4Y1,RPS4Y2 [cytosol]Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntityRPS4Y1 [cytosol]RPS4X [cytosol]

UniProtP22090UniProtP62701

Reactome DB_ID: 72383

UniProt:P62081 RPS7

RPS7

RPS7FUNCTION Required for rRNA maturation.SUBUNIT Binds IPO9 with high affinity (PubMed:11823430). Interacts with NEK6 (PubMed:20873783). Interacts with DESI2 (PubMed:28483520).PTM Phosphorylated by NEK6.PTM Ubiquitinated. Deubiquitinated by DESI2, leading to its stabilization.SIMILARITY Belongs to the eukaryotic ribosomal protein eS7 family.

UniProtP62081

EQUAL

194

EQUAL

Reactome DB_ID: 72343

UniProt:P39019 RPS19

RPS19

RPS19FUNCTION Required for pre-rRNA processing and maturation of 40S ribosomal subunits.SUBUNIT Interacts with RPS19BP1.TISSUE SPECIFICITY Higher level expression is seen in the colon carcinoma tissue than normal colon tissue.SIMILARITY Belongs to the eukaryotic ribosomal protein eS19 family.

UniProtP39019

EQUAL

145

EQUAL

Reactome DB_ID: 72331

UniProt:P62277 RPS13

RPS13

RPS13SIMILARITY Belongs to the universal ribosomal protein uS15 family.

UniProtP62277

EQUAL

151

EQUAL

Reactome DB_ID: 72391

EMBL:X03205 18S rRNA18S rRNA

EMBLX03205

Reactome DB_ID: 72347

UniProt:P15880 RPS2

RPS2

RPS4RPS2PTM Citrullinated by PADI4 in the Arg/Gly-rich region.PTM Asymmetric arginine dimethylation by PRMT3 occurs at multiple sites in the Arg/Gly-rich region.SIMILARITY Belongs to the universal ribosomal protein uS5 family.

UniProtP15880

EQUAL

293

EQUAL

Reactome DB_ID: 72387

UniProt:P46781 RPS9

RPS9

RPS9SUBUNIT Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs.SIMILARITY Belongs to the universal ribosomal protein uS4 family.

UniProtP46781

EQUAL

194

EQUAL

Reactome DB_ID: 72369

UniProt:P23396 RPS3

RPS3

OK/SW-cl.26RPS3FUNCTION Involved in translation as a component of the 40S small ribosomal subunit (PubMed:8706699). Has endonuclease activity and plays a role in repair of damaged DNA (PubMed:7775413). Cleaves phosphodiester bonds of DNAs containing altered bases with broad specificity and cleaves supercoiled DNA more efficiently than relaxed DNA (PubMed:15707971). Displays high binding affinity for 7,8-dihydro-8-oxoguanine (8-oxoG), a common DNA lesion caused by reactive oxygen species (ROS) (PubMed:14706345). Has also been shown to bind with similar affinity to intact and damaged DNA (PubMed:18610840). Stimulates the N-glycosylase activity of the base excision protein OGG1 (PubMed:15518571). Enhances the uracil excision activity of UNG1 (PubMed:18973764). Also stimulates the cleavage of the phosphodiester backbone by APEX1 (PubMed:18973764). When located in the mitochondrion, reduces cellular ROS levels and mitochondrial DNA damage (PubMed:23911537). Has also been shown to negatively regulate DNA repair in cells exposed to hydrogen peroxide (PubMed:17049931). Plays a role in regulating transcription as part of the NF-kappa-B p65-p50 complex where it binds to the RELA/p65 subunit, enhances binding of the complex to DNA and promotes transcription of target genes (PubMed:18045535). Represses its own translation by binding to its cognate mRNA (PubMed:20217897). Binds to and protects TP53/p53 from MDM2-mediated ubiquitination (PubMed:19656744). Involved in spindle formation and chromosome movement during mitosis by regulating microtubule polymerization (PubMed:23131551). Involved in induction of apoptosis through its role in activation of CASP8 (PubMed:14988002). Induces neuronal apoptosis by interacting with the E2F1 transcription factor and acting synergistically with it to up-regulate pro-apoptotic proteins BCL2L11/BIM and HRK/Dp5 (PubMed:20605787). Interacts with TRADD following exposure to UV radiation and induces apoptosis by caspase-dependent JNK activation (PubMed:22510408).ACTIVITY REGULATION Endonuclease activity is inhibited by MgCl2 on apurinic/apyrimidinic DNA but not on UV-irradiated DNA.SUBUNIT Component of the 40S small ribosomal subunit (PubMed:8706699). Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs (PubMed:17289661). Interacts with HNRPD (PubMed:24423872). Interacts with PRMT1; the interaction methylates RPS3 (PubMed:19460357). Interacts with SUMO1; the interaction sumoylates RPS3 (PubMed:21968017). Interacts with UBC9 (PubMed:21968017). Interacts with CDK1; the interaction phosphorylates RPS3 (PubMed:21871177). Interacts with PRKCD; the interaction phosphorylates RPS3 (PubMed:19059439). Interacts with PKB/AKT; the interaction phosphorylates RPS3 (PubMed:20605787). Interacts with E2F1; the interaction occurs in the absence of nerve growth factor and increases transcription of pro-apoptotic proteins BCL2L11/BIM and HRK/Dp5 (PubMed:20605787). Interacts with the base excision repair proteins APEX1 and OGG1; interaction with OGG1 increases OGG1 N-glycosylase activity (PubMed:15518571). Interacts with UNG; the interaction increases the uracil excision activity of UNG1 (PubMed:18973764). Interacts with HSP90; the interaction prevents the ubiquitination and proteasome-dependent degradation of RPS3 and is suppressed by increased ROS levels (PubMed:16314389). Interacts with TOM70; the interaction promotes translocation of RPS3 to the mitochondrion (PubMed:23911537). Interacts (via N-terminus) with RELA (via N-terminus); the interaction enhances the DNA-binding activity of the NF-kappa-B p65-p50 complex (PubMed:18045535). Interacts with NFKBIA; the interaction is direct and may bridge the interaction between RPS3 and RELA (PubMed:24457201). Interacts with IKKB; the interaction phosphorylates RPS3 and enhances its translocation to the nucleus (PubMed:21399639). Interacts (via KH domain) with MDM2 and TP53 (PubMed:19656744). Interacts with TRADD (PubMed:22510408). Interacts (via N-terminus) with E.coli O157:H7 (strain EDL933) nleH1 and nleH2; the interaction with nleH1 inhibits phosphorylation by IKKB, reduces RPS3 nuclear abundance and inhibits transcriptional activation by the NF-kappa-B p65-p50 complex (PubMed:20041225, PubMed:21399639). Identified in a HCV IRES-mediated translation complex, at least composed of EIF3C, IGF2BP1, RPS3 and HCV RNA-replicon (PubMed:19541769). Interacts with CRY1 (By similarity).PTM Methylation by PRMT1 is required for import into the nucleolus and for ribosome assembly.PTM Sumoylation by SUMO1 enhances protein stability through increased resistance to proteolysis. Sumoylation occurs at one or more of the three consensus sites, Lys-18, Lys-214 and Lys-230.PTM Phosphorylation at Thr-221 by CDK1 occurs mainly in G2/M phase (PubMed:21871177). Phosphorylation by PRKCD occurs on a non-ribosomal-associated form which results in translocation of RPS3 to the nucleus and enhances its endonuclease activity (PubMed:19059439). Phosphorylated on Ser-209 by IKKB in response to activation of the NF-kappa-B p65-p50 complex which enhances the association of RPS3 with importin-alpha and mediates the nuclear translocation of RPS3 (PubMed:21399639). Phosphorylation by MAPK is required for translocation to the nucleus following exposure of cells to DNA damaging agents such as hydrogen peroxide (PubMed:17560175). Phosphorylation by PKB/AKT mediates RPS3 nuclear translocation, enhances RPS3 endonuclease activity and suppresses RPS3-induced neuronal apoptosis (PubMed:20605787).PTM Ubiquitinated (PubMed:16314389). This is prevented by interaction with HSP90 which stabilizes the protein (PubMed:16314389). Monoubiquitinated at Lys-214 by ZNF598 when a ribosome has stalled during translation of poly(A) sequences, leading to preclude synthesis of a long poly-lysine tail and initiate the ribosome quality control (RQC) pathway to degrade the potentially detrimental aberrant nascent polypeptide (PubMed:28065601, PubMed:28132843).SIMILARITY Belongs to the universal ribosomal protein uS3 family.

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Reactome DB_ID: 72381

UniProt:P62753 RPS6

RPS6

OK/SW-cl.2RPS6FUNCTION May play an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA.PTM Ribosomal protein S6 is the major substrate of protein kinases in eukaryote ribosomes. The phosphorylation is stimulated by growth factors, tumor promoting agents, and mitogens. It is dephosphorylated at growth arrest. Phosphorylated at Ser-235 and Ser-236 by RPS6KA1 and RPS6KA3; phosphorylation at these sites facilitates the assembly of the preinitiation complex.PTM Specifically hydroxylated (with R stereochemistry) at C-3 of Arg-137 by KDM8.SIMILARITY Belongs to the eukaryotic ribosomal protein eS6 family.

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Reactome DB_ID: 72389

UniProt:P08865 RPSA

RPSA

LAMBRRPSALAMR1FUNCTION Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Acts as a PPP1R16B-dependent substrate of PPP1CA.FUNCTION (Microbial infection) Acts as a receptor for the Adeno-associated viruses 2,3,8 and 9.FUNCTION (Microbial infection) Acts as a receptor for the Dengue virus.FUNCTION (Microbial infection) Acts as a receptor for the Sindbis virus.FUNCTION (Microbial infection) Acts as a receptor for the Venezuelan equine encephalitis virus.FUNCTION (Microbial infection) Acts as a receptor for the pathogenic prion protein.FUNCTION (Microbial infection) Acts as a receptor for bacteria.SUBUNIT Monomer (37LRP) and homodimer (67LR). Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Interacts with RPS21. Interacts with several laminins including at least LAMB1. Interacts with MDK (By similarity). The mature dimeric form interacts with PPP1R16B (via its fourth ankyrin repeat). Interacts with PPP1CA only in the presence of PPP1R16B.SUBUNIT (Microbial infection) 67LR interacts with capsid protein of Adeno-associated virus 2,3,8 and 9.SUBUNIT (Microbial infection) 67LR interacts with envelope protein of dengue virus.SUBUNIT (Microbial infection) 6s7LR interacts with E2 glycoprotein of Sindbis and Venezuelan equine encephalitis virus (PubMed:8764073, PubMed:1385835).PTM Acylated. Acylation may be a prerequisite for conversion of the monomeric 37 kDa laminin receptor precursor (37LRP) to the mature dimeric 67 kDa laminin receptor (67LR), and may provide a mechanism for membrane association (PubMed:9581863).PTM Cleaved by stromelysin-3 (ST3) at the cell surface. Cleavage by stromelysin-3 may be a mechanism to alter cell-extracellular matrix interactions.MISCELLANEOUS This protein appears to have acquired a second function as a laminin receptor specifically in the vertebrate lineage.MISCELLANEOUS It is thought that in vertebrates 37/67 kDa laminin receptor acquired a dual function during evolution. It developed from the ribosomal protein SA, playing an essential role in the protein biosynthesis lacking any laminin binding activity, to a cell surface receptor with laminin binding activity.SIMILARITY Belongs to the universal ribosomal protein uS2 family.

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Reactome DB_ID: 72357

UniProt:P62851 RPS25

RPS25

RPS25SIMILARITY Belongs to the eukaryotic ribosomal protein eS25 family.

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Reactome DB_ID: 72335

UniProt:P62841 RPS15

RPS15

RPS15RIGSIMILARITY Belongs to the universal ribosomal protein uS19 family.

UniProtP62841

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Reactome DB_ID: 72373

UniProt:P61247 RPS3A

RPS3A

MFTLRPS3AFTE1FUNCTION May play a role during erythropoiesis through regulation of transcription factor DDIT3.SUBUNIT Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Binds with high affinity to IPO4. Interacts with DDIT3.SIMILARITY Belongs to the eukaryotic ribosomal protein eS1 family.

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264

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Reactome DB_ID: 72379

UniProt:P46782 RPS5

RPS5

RPS5SIMILARITY Belongs to the universal ribosomal protein uS7 family.

UniProtP46782

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Reactome DB_ID: 72385

UniProt:P62241 RPS8

RPS8

RPS8OK/SW-cl.83SUBUNIT Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs.SIMILARITY Belongs to the eukaryotic ribosomal protein eS8 family.

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Reactome DB_ID: 72339

UniProt:P08708 RPS17

RPS17

RPS17RPS17LSIMILARITY Belongs to the eukaryotic ribosomal protein eS17 family.

UniProtP08708

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135

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Reactome DB_ID: 72359

UniProt:P62854 RPS26

RPS26

RPS26SUBUNIT Component of the 40S small ribosomal subunit.SIMILARITY Belongs to the eukaryotic ribosomal protein eS26 family.

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Reactome DB_ID: 72367

UniProt:P62273 RPS29

RPS29

RPS29SUBUNIT Component of the 40S small ribosomal subunit.SIMILARITY Belongs to the universal ribosomal protein uS14 family.

UniProtP62273

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Reactome DB_ID: 72341

UniProt:P62269 RPS18

RPS18

RPS18D6S218EFUNCTION Located at the top of the head of the 40S subunit, it contacts several helices of the 18S rRNA.SIMILARITY Belongs to the universal ribosomal protein uS13 family.

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Reactome DB_ID: 72371

UniProt:P62861 FAU

FAU

FAUMISCELLANEOUS This ribosomal protein is synthesized as a C-terminal extension protein (CEP) of a ubiquitin-like protein.SIMILARITY Belongs to the eukaryotic ribosomal protein eS30 family.

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Reactome DB_ID: 72325

UniProt:P46783 RPS10

RPS10

RPS10FUNCTION Component of the 40S ribosomal subunit.SUBUNIT Component of the small ribosomal subunit. Interacts with PRMT5. The methylated form interacts with NPM1.PTM Methylated by PRMT5. Methylation is necessary for its interaction with NPS1, its localization in the granular component (GC) region of the nucleolus, for the proper assembly of ribosomes, protein synthesis and optimal cell proliferation.PTM Monoubiquitinated by ZNF598 when a ribosome has stalled during translation of poly(A) sequences, leading to preclude synthesis of a long poly-lysine tail and initiate the ribosome quality control (RQC) pathway to degrade the potentially detrimental aberrant nascent polypeptide (PubMed:28065601, PubMed:28132843).SIMILARITY Belongs to the eukaryotic ribosomal protein eS10 family.

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Reactome DB_ID: 72365

UniProt:P62857 RPS28

RPS28

RPS28SUBUNIT Component of the 40S small ribosomal subunit.SIMILARITY Belongs to the eukaryotic ribosomal protein eS28 family.

UniProtP62857

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Reactome DB_ID: 72333

UniProt:P62263 RPS14

RPS14

RPS14PRO2640SIMILARITY Belongs to the universal ribosomal protein uS11 family.

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Reactome DB_ID: 72355

UniProt:P62847 RPS24

RPS24

RPS24FUNCTION Required for processing of pre-rRNA and maturation of 40S ribosomal subunits.TISSUE SPECIFICITY Mature tissues, such as adult brain, skeletal muscle, heart, and kidney, express low levels, whereas tissues and organs with significant populations of proliferating cells, such as fetal brain, placenta, bone marrow, and various glandular organs, contain significantly higher levels.SIMILARITY Belongs to the eukaryotic ribosomal protein eS24 family.

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Reactome DB_ID: 72363

UniProt:P62979 RPS27A

RPS27A

UBA80RPS27AUBCEP1SUBUNIT Ribosomal protein S27a is part of the 40S ribosomal subunit.MISCELLANEOUS Ubiquitin is encoded by 4 different genes. UBA52 and RPS27A genes code for a single copy of ubiquitin fused to the ribosomal proteins L40 and S27a, respectively. UBB and UBC genes code for a polyubiquitin precursor with exact head to tail repeats, the number of repeats differ between species and strains.MISCELLANEOUS For a better understanding, features related to ubiquitin are only indicated for the first chain.SIMILARITY In the N-terminal section; belongs to the ubiquitin family.SIMILARITY In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family.

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Converted from EntitySet in Reactome

Reactome DB_ID: 8868839

RPS27,RPS27L [cytosol]Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntityRPS27 [cytosol]

UniProtP42677

Reactome DB_ID: 72337

UniProt:P62249 RPS16

RPS16

RPS16SIMILARITY Belongs to the universal ribosomal protein uS9 family.

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Reactome DB_ID: 72345

UniProt:P62244 RPS15A

RPS15A

RPS15AOK/SW-cl.82FUNCTION Structural component of the ribosome (PubMed:23636399). Required for proper erythropoiesis (PubMed:27909223).SUBUNIT Component of the 40S ribosomal subunit.SIMILARITY Belongs to the universal ribosomal protein uS8 family.

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Reactome DB_ID: 72327

UniProt:P62280 RPS11

RPS11

RPS11PTM Citrullinated by PADI4.SIMILARITY Belongs to the universal ribosomal protein uS17 family.

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158

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Reactome Database ID Release 7272392Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=72392ReactomeR-HSA-72392

Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-72392.2Reactome Database ID Release 7272500Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=72500ReactomeR-HSA-72500

Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-72500.1

Reactome DB_ID: 72323

mRNA [cytosol]

mRNA

messenger RNA

Reactome DB_ID: 72393

Met-tRNAi [cytosol]

Met-tRNAi

methionyl initiator tRNAMet-tRNAffMet-tRNA

Reactome Database ID Release 7272505Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=72505ReactomeR-HSA-72505

Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-72505.1

Reactome DB_ID: 5357715

UniProt:Q96T21 SECISBP2

SECISBP2

SECISBP2SBP2FUNCTION Binds to the SECIS element in the 3'-UTR of some mRNAs encoding selenoproteins. Binding is stimulated by SELB.SUBUNIT Interacts with SELB.TISSUE SPECIFICITY Expressed at high levels in testis.

UniProtQ96T21

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854

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Reactome DB_ID: 5359044

80S:Met-tRNAi:mRNA:SECISBP2:Sec-tRNA(Sec):EEFSEC:GTP [cytosol]

80S:Met-tRNAi:mRNA:SECISBP2:Sec-tRNA(Sec):EEFSEC:GTP

Reactome DB_ID: 72505

Reactome DB_ID: 5359036

Reactome DB_ID: 5357715

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854

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Reactome Database ID Release 725359044Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5359044ReactomeR-HSA-5359044

Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5359044.1Reactome Database ID Release 722408529Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2408529ReactomeR-HSA-2408529

Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-2408529.115821744Pubmed2005Ribosomal protein L30 is a component of the UGA-selenocysteine recoding machinery in eukaryotesChavatte, LaurentBrown, Bernard ADriscoll, Donna MNat. Struct. Mol. Biol. 12:408-16