BioPAX pathway converted from "SeO3(2-) combines with GSH to form GSSeSG and GSSG" in the Reactome database. SeO3(2-) combines with GSH to form GSSeSG and GSSG SeO3(2-) combines with GSH to form GSSeSG and GSSG In the rat cytosol, selenite (SeO3(2-)) and reduced glutathione (GSH) spontaneously react to form selenodiglutathione (GSSeSG) and glutathione disulfide (GSSG). This has been proposed to be the major form of entry of selenium compounds into metabolism (Bjornstedt et al. 1992). Authored: Williams, MG, 2014-05-06 Reviewed: Rush, MG, 2015-08-30 Edited: D'Eustachio, Peter, 2015-08-29 Reactome DB_ID: 29450 4 cytosol GO 0005829 glutathionate(1-) [ChEBI:57925] glutathionate(1-) glutathionate anion glutathionate ion glutathione glutathionate Reactome http://www.reactome.org ChEBI 57925 Reactome DB_ID: 70106 3 hydron [ChEBI:15378] hydron ChEBI 15378 Reactome DB_ID: 5357720 1 selenite(2-) [ChEBI:18212] selenite(2-) ChEBI 18212 Reactome DB_ID: 5357667 1 selenodiglutathione(2-) [ChEBI:71259] selenodiglutathione(2-) selenodiglutathione GSSeSG(2-) ChEBI 71259 Reactome DB_ID: 29356 3 water [ChEBI:15377] water ChEBI 15377 Reactome DB_ID: 111745 1 glutathione disulfide(2-) [ChEBI:58297] glutathione disulfide(2-) glutathione disulfide (2S,2'S)-5,5'-[disulfanediylbis({(2R)-3-[(carboxylatomethyl)amino]-3-oxopropane-1,2-diyl}imino)]bis(2-azaniumyl-5-oxopentanoate) glutathione disulfide dianion ChEBI 58297 Reactome Database ID Release 83 2408553 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2408553 Reactome R-RNO-2408553 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-RNO-2408553.1 1569062 Pubmed 1992 Selenodiglutathione is a highly efficient oxidant of reduced thioredoxin and a substrate for mammalian thioredoxin reductase Björnstedt, M Kumar, S Holmgren, Arne J. Biol. Chem. 267:8030-4