BioPAX pathway converted from "NOTCH1 PEST domain mutants bind DLL4" in the Reactome database. NOTCH1 PEST domain mutants bind DLL4 NOTCH1 PEST domain mutants bind DLL4 NOTCH1 PEST domain mutants are expected to bind to DLL4 ligand in an identical fashion to wild-type NOTCH1 (Koch et al. 2008, Hozumi et al. 2008, Benedito et al. 2009). Authored: Orlic-Milacic, M, 2013-01-04 Reviewed: Haw, R, 2013-02-10 Edited: Jassal, B, 2013-01-09 Reactome DB_ID: 158437 1 plasma membrane GO 0005886 UniProt:Q9NR61 DLL4 DLL4 DLL4 UNQ1895/PRO4341 FUNCTION Involved in the Notch signaling pathway as Notch ligand (PubMed:11134954). Activates NOTCH1 and NOTCH4. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting (PubMed:20616313). Essential for retinal progenitor proliferation. Required for suppressing rod fates in late retinal progenitors as well as for proper generation of other retinal cell types (By similarity). During spinal cord neurogenesis, inhibits V2a interneuron fate (PubMed:17728344).SUBUNIT Interacts with NOTCH4. Interacts (via N-terminal DSL and MNNL domains) with NOTCH1 (via EGF-like domains).TISSUE SPECIFICITY Expressed in vascular endothelium.DOMAIN The Delta-Serrate-Lag2 (DSL) domain is required for binding to the Notch receptor. Reactome http://www.reactome.org Homo sapiens NCBI Taxonomy 9606 UniProt Q9NR61 Chain Coordinates 27 EQUAL 685 EQUAL Converted from EntitySet in Reactome Reactome DB_ID: 2220939 1 NOTCH1 PEST domain mutants [plasma membrane] Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntity Reactome DB_ID: 2768992 1 DLL4:NOTCH1 PEST Domain Mutants [plasma membrane] DLL4:NOTCH1 PEST Domain Mutants Reactome DB_ID: 158437 1 27 EQUAL 685 EQUAL Converted from EntitySet in Reactome Reactome DB_ID: 2220939 1 Reactome Database ID Release 81 2768992 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2768992 Reactome R-HSA-2768992 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-2768992.1 Reactome Database ID Release 81 2769000 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=2769000 Reactome R-HSA-2769000 2 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-2769000.2 18824583 Pubmed 2008 Delta-like 4 is indispensable in thymic environment specific for T cell development Hozumi, K Mailhos, C Negishi, N Hirano, K Yahata, T Ando, K Zuklys, S Holländer, GA Shima, DT Habu, S J Exp Med 205:2507-13 19524514 Pubmed 2009 The notch ligands Dll4 and Jagged1 have opposing effects on angiogenesis Benedito, R Roca, C Sörensen, I Adams, S Gossler, A Fruttiger, M Adams, Ralf H Cell 137:1124-35 18824585 Pubmed 2008 Delta-like 4 is the essential, nonredundant ligand for Notch1 during thymic T cell lineage commitment Koch, U Fiorini, E Benedito, R Besseyrias, V Schuster-Gossler, K Pierres, M Manley, NR Duarte, A MacDonald, HR Radtke, F J Exp Med 205:2515-23