BioPAX pathway converted from "Activation of Rap1 by cytosolic GEFs" in the Reactome database.Activation of Rap1 by cytosolic GEFsActivation of Rap1 by cytosolic GEFsSignals from agonist receptors (such as GPVI) trigger the production of PIP3, DAG, cAMP and elevated Ca++ levels. This leads to the activation and translocation of active Rap1-GTP to the plasma membrane. Rap-GEFs stimulate the replacement of GDP for GTP, activating Rap1. Several Rap1 GEFs have been identified enabling Rap1 to respond to diverse stimuli. CalDAG-GEFs activate Rap1 in response to calcium and DAG, downstream of Phospholipase C. EPAC (exchange proteins directly activated by cAMP) GEFs are activated by binding cAMP.Authored: Garapati, P V, 2008-06-16 17:13:06Reviewed: Shattil, SJ, 2008-09-16 06:21:39Edited: Garapati, P V, 2008-06-16 17:13:06Reactome DB_ID: 294381cytosolGO0005829GTP [ChEBI:15996]GTPGuanosine 5'-triphosphateReactomehttp://www.reactome.orgChEBI15996Reactome DB_ID: 3540741plasma membraneGO0005886RAP1:GDP [plasma membrane]RAP1:GDPReactome DB_ID: 294201GDP [ChEBI:17552]GDPGuanosine 5'-diphosphateGuanosine diphosphateChEBI17552Converted from EntitySet in ReactomeReactome DB_ID: 3776001RAP1 [plasma membrane]Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntityRAP1A [plasma membrane]RAP1B [plasma membrane]Homo sapiensNCBI Taxonomy9606UniProtP62834UniProtP61224Reactome Database ID Release 75354074Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=354074ReactomeR-HSA-3540742Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-354074.2Reactome DB_ID: 294201Reactome DB_ID: 3541261RAP1:GTP [plasma membrane]RAP1:GTPReactome DB_ID: 294381Converted from EntitySet in ReactomeReactome DB_ID: 3776001Reactome Database ID Release 75354126Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=354126ReactomeR-HSA-3541262Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-354126.2PHYSIOL-LEFT-TO-RIGHTACTIVATIONReactome DB_ID: 392841CalDAG-GEFs:DAG:Ca2+ [plasma membrane]CalDAG-GEFs:DAG:Ca2+Reactome DB_ID: 740161calcium(2+) [ChEBI:29108]calcium(2+)ChEBI29108Converted from EntitySet in ReactomeReactome DB_ID: 3924881CalDAG-GEFs [cytosol]Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntityRASGRP2 [cytosol]RASGRP1 [cytosol]UniProtQ7LDG7UniProtO95267Reactome DB_ID: 11451911,2-diacyl-sn-glycerol [ChEBI:17815]1,2-diacyl-sn-glycerolChEBI17815Reactome Database ID Release 75392841Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=392841ReactomeR-HSA-3928411Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-392841.1GO0005085GO molecular functionReactome Database ID Release 75354106Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=354106Reactome Database ID Release 75354173Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=354173ReactomeR-HSA-3541732Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-354173.212585966Pubmed2003Bidirectional integrin alphaIIbbeta3 signalling regulating platelet adhesion under flow: contribution of protein kinase CGiuliano, SNesbitt, WSRooney, MJackson, SPBiochem J 372:163-7215469846Pubmed2004RIAM, an Ena/VASP and Profilin ligand, interacts with Rap1-GTP and mediates Rap1-induced adhesionLafuente, EMvan Puijenbroek, AAKrause, MCarman, CVFreeman, GJBerezovskaya, AConstantine, ESpringer, TAGertler, FBBoussiotis, VADev Cell 7:585-9516757337Pubmed2006Rap1 regulation of RIAM and cell adhesionLafuente, EBoussiotis, VAMethods Enzymol 407:345-5815334074Pubmed2004CalDAG-GEFI integrates signaling for platelet aggregation and thrombus formationCrittenden, JRBergmeier, WZhang, YPiffath, CLLiang, YWagner, DDHousman, DEGraybiel, AMNat Med 10:982-616076873Pubmed2005Multiple roles of Rap1 in hematopoietic cells: complementary versus antagonistic functionsStork, PJDillon, TJBlood 106:2952-61