BioPAX pathway converted from "DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2" in the Reactome database.2.7.1.68DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2Stimulation of the WNT pathway controls the activity of PIP5KB in a FZD- and DVL-dependent manner (Pan et al, 2008; Bilic et al, 2007; Cong et al, 2004; Qin et al, 2009). Activation of PIP5KB results in the formation of PI(4,5)P2 at the plasma membrane, which is required through an unclear mechanism for the phosphorylation of LRP6 at serine 1490, LRP6 aggregation into 'signalosomes' and LRP6 phosphorylation at threonine 1479. These events are required for the recruitment of AXIN to the plasma membrane (Pan et al, 2008; Qin et al, 2009).Authored: Rothfels, K, 2013-05-29Reviewed: Rajakulendran, Nishani, 2014-01-22Reviewed: van Amerongen, R, 2014-02-14Reviewed: Kikuchi, Akira, 2014-04-22Edited: Gillespie, ME, 2013-10-02Reactome DB_ID: 3924171plasma membraneGO00058861-phosphatidyl-1D-myo-inositol 4-phosphate [ChEBI:17526]1-phosphatidyl-1D-myo-inositol 4-phosphateReactomehttp://www.reactome.orgChEBI17526Reactome DB_ID: 1135921cytosolGO0005829ATP(4-) [ChEBI:30616]ATP(4-)Adenosine 5'-triphosphateatpATPChEBI30616Reactome DB_ID: 293701ADP(3-) [ChEBI:456216]ADP(3-)ADP trianion5'-O-[(phosphonatooxy)phosphinato]adenosineADPChEBI456216Reactome DB_ID: 17985611-phosphatidyl-1D-myo-inositol 4,5-bisphosphate [ChEBI:18348]1-phosphatidyl-1D-myo-inositol 4,5-bisphosphatePIP2ChEBI18348PHYSIOL-LEFT-TO-RIGHTACTIVATIONReactome DB_ID: 3772421ppDVL:PIP5K1B [cytosol]ppDVL:PIP5K1BReactome DB_ID: 18062161UniProt:O14986 PIP5K1BPIP5K1BPIP5K1BSTM7FUNCTION Participates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. Mediates RAC1-dependent reorganization of actin filaments. Contributes to the activation of PLD2. Together with PIP5K1A is required after stimulation of G-protein coupled receptors for stable platelet adhesion (By similarity).SUBUNIT Interacts with RAC1, AJUBA, PLD1, PLD2 and ARF1.TISSUE SPECIFICITY Detected in heart, pancreas, brain, kidney, skeletal muscle and lung.CAUTION There is confusion in the literature with phosphatidylinositol 4-phosphate 5-kinase type I nomenclature due to the fact that frequently mouse PIP5K1B is named Phosphatidylinositol 4-phosphate 5-kinase type I alpha.Homo sapiensNCBI Taxonomy9606UniProtO14986Chain Coordinates1EQUAL540EQUALConverted from EntitySet in ReactomeReactome DB_ID: 37724071pp-DVL [cytosol]Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntitypp-DVL3 [cytosol]pp-DVL1 [cytosol]pp-DVL2 [cytosol]UniProtQ92997UniProtO14640UniProtO14641Reactome Database ID Release 753772421Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3772421ReactomeR-HSA-37724211Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-3772421.1GO0016308GO molecular functionReactome Database ID Release 753772432Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3772432Reactome Database ID Release 753772436Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3772436ReactomeR-HSA-37724361Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-3772436.115459103Pubmed2004Wnt signals across the plasma membrane to activate the beta-catenin pathway by forming oligomers containing its receptors, Frizzled and LRPCong, FSchweizer, LVarmus, HDevelopment 131:5103-1519561074Pubmed2009Regulation of phosphatidylinositol kinases and metabolism by Wnt3a and DvlQin, YuanboLi, LPan, WeijunWu, DianqingJ. Biol. Chem. 284:22544-818772438Pubmed2008Wnt3a-mediated formation of phosphatidylinositol 4,5-bisphosphate regulates LRP6 phosphorylationPan, WeijunChoi, Sun-CheolWang, HeQin, YuanboVolpicelli-Daley, LauraSwan, LauraLucast, LouiseKhoo, CynthiaZhang, XiaowuLi, LAbrams, Charles SSokol, Sergei YWu, DianqingScience 321:1350-317569865Pubmed2007Wnt induces LRP6 signalosomes and promotes dishevelled-dependent LRP6 phosphorylationBilic, JHuang, YLDavidson, GaryZimmermann, TCruciat, CMBienz, MNiehrs, CScience 316:1619-22