BioPAX pathway converted from "Na+/H+ exchanger transport (at cell membrane)" in the Reactome database.Na+/H+ exchanger transport (at cell membrane)Na+/H+ exchanger transport (at cell membrane)NHE1 (SLC9A1) is present in most cells and is the most extensively characterized member of this family (Sardet C et al, 1989). NHE2-4 (SLC9A2-4) (Malakooti J et al, 1999; Brant SR et al, 1995) are expressed mainly in the kidney and GI tract. NHE5 (SLC9A5) (Baird NR et al, 1999) is highly expressed in neuronal-enriched areas of the CNS. Authored: Jassal, Bijay, 2009-06-11Reviewed: He, L, 2009-08-24Edited: Jassal, Bijay, 2009-06-11Reactome DB_ID: 741131extracellular regionGO0005576sodium(1+) [ChEBI:29101]sodium(1+)Reactomehttp://www.reactome.orgChEBI29101Reactome DB_ID: 701061cytosolGO0005829hydron [ChEBI:15378]hydronChEBI15378Reactome DB_ID: 839101Reactome DB_ID: 3516261PHYSIOL-LEFT-TO-RIGHTACTIVATIONConverted from EntitySet in ReactomeReactome DB_ID: 425963plasma membraneGO0005886SLC9A1-5 [plasma membrane]Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntitySLC9A3 [plasma membrane]SLC9A5 [plasma membrane]SLC9A1 [plasma membrane]SLC9A4 [plasma membrane]SLC9A2 [plasma membrane]Homo sapiensNCBI Taxonomy9606UniProtP48764UniProtQ14940UniProtP19634UniProtQ6AI14UniProtQ9UBY0GO0015385GO molecular functionReactome Database ID Release 75425966Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=425966Reactome Database ID Release 75425994Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=425994ReactomeR-HSA-4259941Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-425994.110444453Pubmed1999Molecular cloning, tissue distribution, and functional expression of the human Na(+)/H(+) exchanger NHE2Malakooti, JDahdal, RYSchmidt, LLayden, TJDudeja, PKRamaswamy, KAm J Physiol 277:G383-909933641Pubmed1999Molecular cloning, genomic organization, and functional expression of Na+/H+ exchanger isoform 5 (NHE5) from human brainBaird, NROrlowski, JSzabó, EZZaun, HCSchultheis, PJMenon, AGShull, GEJ Biol Chem 274:4377-822536298Pubmed1989Molecular cloning, primary structure, and expression of the human growth factor-activatable Na+/H+ antiporterSardet, CFranchi, APouysségur, JacquesCell 56:271-807631746Pubmed1995Cloning, tissue distribution, and functional analysis of the human Na+/N+ exchanger isoform, NHE3Brant, SRYun, CHDonowitz, MTse, CMAm J Physiol 269:C198-206