BioPAX pathway converted from "viral dsRNA binds the toll-like receptor 3 (TLR3)" in the Reactome database. viral dsRNA binds the toll-like receptor 3 (TLR3) viral dsRNA binds the toll-like receptor 3 (TLR3) Viral dsRNA triggers an antiviral pathway mediated by toll like receptor 3. TLR3 dimerization occurs upon ligand binding to positivly charged residues on the ectodomain termini of TLR3 wich are responsible for the interaction with sugar-phosphate groups of dsRNA. Authored: Shamovsky, V, 2009-08-26 Reviewed: D'Eustachio, P, 2010-05-23 Edited: Shamovsky, V, 2010-05-04 Reactome DB_ID: 433892 2 endosome membrane GO 0010008 UniProt:Q0PQ88 Toll-like receptor 3 Toll-like receptor 3 TLR3 SIMILARITY Contains 1 TIR domain. Reactome http://www.reactome.org Gallus gallus NCBI Taxonomy 9031 UniProt Q0PQ88 Chain Coordinates 1 EQUAL 1011 EQUAL Reactome DB_ID: 9014378 1 endosome lumen GO 0031904 IBV dsRNA intermediate form [endosome lumen] IBV dsRNA intermediate form Reactome DB_ID: 433883 1 viral dsRNA:TLR3 [endosome membrane] viral dsRNA:TLR3 Reactome DB_ID: 433892 2 1 EQUAL 1011 EQUAL Reactome DB_ID: 9014378 1 Reactome Database ID Release 83 433883 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=433883 Reactome R-GGA-433883 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-433883.3 Reactome Database ID Release 83 434004 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=434004 Reactome R-GGA-434004 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-434004.3 17316136 Pubmed 2007 Chicken toll-like receptor 3 recognizes its cognate ligand when ectopically expressed in human cells Schwarz, H Schneider, K Ohnemus, A Lavric, M Kothlow, S Bauer, S Kaspers, B Staeheli, P J Interferon Cytokine Res 27:97-101 25378498 Pubmed 2015 Activation of the chicken type I interferon response by infectious bronchitis coronavirus Kint, Joeri Fernandez-Gutierrez, Marcela Maier, Helena J Britton, Paul Langereis, Martijn A Koumans, Joseph Wiegertjes, Geert F Forlenza, Maria J. Virol. 89:1156-67 18420935 Pubmed 2008 Structural basis of toll-like receptor 3 signaling with double-stranded RNA Liu, L Botos, I Wang, Y Leonard, JN Shiloach, J Segal, DM Davies, DR Science 320:379-81