BioPAX pathway converted from "Activation and dimerization of c-JUN in the nucleus" in the Reactome database. 2.7.11 Activation and dimerization of c-JUN in the nucleus Activation and dimerization of c-JUN in the nucleus Shortly after phosphorylation JNKs are translocated to nucleus where they associate and activate their target transcription factors. Authored: Shamovsky, V, 2009-09-22 Reviewed: D'Eustachio, P, 2010-05-23 Edited: Shamovsky, V, 2010-05-04 Reactome DB_ID: 29358 4 nucleoplasm GO 0005654 ATP(4-) [ChEBI:30616] ATP(4-) Adenosine 5'-triphosphate atp ATP Reactome http://www.reactome.org ChEBI 30616 Reactome DB_ID: 438016 2 UniProt:P18870 JUN JUN JUN FUNCTION Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. May be involved in activated KRAS-mediated transcriptional activation of USP28. May bind to the USP28 promoter.SUBUNIT Interacts with FOS to form a dimer. Interacts with Gallid herpesvirus 2 MEQ protein.SIMILARITY Belongs to the bZIP family. Jun subfamily. Gallus gallus NCBI Taxonomy 9031 UniProt P18870 Chain Coordinates 1 EQUAL 314 EQUAL Reactome DB_ID: 113582 4 ADP(3-) [ChEBI:456216] ADP(3-) ADP trianion 5'-O-[(phosphonatooxy)phosphinato]adenosine ADP ChEBI 456216 Reactome DB_ID: 437991 1 activated c-JUN dimer [nucleoplasm] activated c-JUN dimer Reactome DB_ID: 438013 2 O-phospho-L-serine at 63 63 EQUAL O-phospho-L-serine [MOD:00046] O-phospho-L-serine at 73 73 EQUAL 1 EQUAL 314 EQUAL Reactome Database ID Release 82 437991 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=437991 Reactome R-GGA-437991 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-437991.1 PHYSIOL-LEFT-TO-RIGHT ACTIVATION Converted from EntitySet in Reactome Reactome DB_ID: 438012 phosphorylated JNK homologs [nucleoplasm] Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntity phosphorylated MAPK9_(JNK2) [nucleoplasm] UniProt P79996 GO 0004705 GO molecular function Reactome Database ID Release 82 438001 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=438001 Reactome Database ID Release 82 438026 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=438026 Reactome R-GGA-438026 2 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-438026.2 18793328 Pubmed 2008 c-Jun expression, activation and function in neural cell death, inflammation and repair Raivich, G J Neurochem 107:898-906 INHIBITION Reactome Database ID Release 82 442857 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=442857 Reactome R-GGA-442857 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-442857.1 Converted from EntitySet in Reactome Reactome DB_ID: 442886 MAPK phosphatases [nucleoplasm] Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntity MKP2 [nucleoplasm] MKP5 [nucleoplasm] MKP1 [nucleoplasm] MKP3 [nucleoplasm] UniProt Q9PW71 UniProt Q5ZJF8 UniProt O42253 UniProt Q7T2L9