BioPAX pathway converted from "G-protein coupled bile acid receptor binds lithocholic acid" in the Reactome database. G-protein coupled bile acid receptor binds lithocholic acid G-protein coupled bile acid receptor binds lithocholic acid The G-protein coupled bile acid receptor (GPBAR1) responds to several bile acids the most potent being lithocholic acid. Primary bile acids are acidic sterols synthesized from cholesterol in the liver where they are conjugated with glycine or taurine. Following synthesis bile acids are stored in the gall bladder and secreted into the duodenum where they facilitate solubilization and absorption of lipid-soluble vitamins and dietary fats. Bile acids can also regulate expression of various transport proteins and enzymes through the binding and activation of nuclear receptors, particularly FXR. Authored: Jupe, S, 2009-10-23 Reviewed: D'Eustachio, P, 2009-12-11 Edited: Jupe, S, 2010-03-01 Reactome DB_ID: 444640 1 plasma membrane GO 0005886 UniProt:Q8TDU6 GPBAR1 GPBAR1 TGR5 GPBAR1 FUNCTION Receptor for bile acid. Bile acid-binding induces its internalization, activation of extracellular signal-regulated kinase and intracellular cAMP production. May be involved in the suppression of macrophage functions by bile acids.TISSUE SPECIFICITY Ubiquitously expressed. Expressed at higher level in spleen and placenta. Expressed at lower level in other tissues. In digestive tissues, it is expressed in stomach, duodenum, ileocecum, ileum, jejunum, ascending colon, transverse colon, descending colon, cecum and liver, but not in esophagus and rectum.SIMILARITY Belongs to the G-protein coupled receptor 1 family. Reactome http://www.reactome.org Homo sapiens NCBI Taxonomy 9606 UniProt Q8TDU6 Chain Coordinates 1 EQUAL 330 EQUAL Converted from EntitySet in Reactome Reactome DB_ID: 444840 1 extracellular region GO 0005576 Bile acids [extracellular region] Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntity LCHA [extracellular region] DCA [extracellular region] CCA [extracellular region] CDCA [extracellular region] ChEBI 29744 ChEBI 28834 ChEBI 29747 ChEBI 36234 Reactome DB_ID: 444843 1 GPBAR1: Bile acids [plasma membrane] GPBAR1: Bile acids Reactome DB_ID: 444640 1 1 EQUAL 330 EQUAL Converted from EntitySet in Reactome Reactome DB_ID: 444840 1 Reactome Database ID Release 81 444843 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=444843 Reactome R-HSA-444843 2 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-444843.2 Reactome Database ID Release 81 444654 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=444654 Reactome R-HSA-444654 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-444654.1 10334992 Pubmed 1999 Identification of a nuclear receptor for bile acids Makishima, M Okamoto, AY Repa, JJ Tu, H Learned, RM Luk, A Hull, MV Lustig, KD Mangelsdorf, DJ Shan, B Science 284:1362-5 12524422 Pubmed 2003 A G protein-coupled receptor responsive to bile acids Kawamata, Y Fujii, R Hosoya, M Harada, M Yoshida, H Miwa, M Fukusumi, S Habata, Y Itoh, T Shintani, Y Hinuma, S Fujisawa, Y Fujino, M J Biol Chem 278:9435-40 1591235 Pubmed 1992 Bile acid biosynthesis Russell, David W Setchell, KD Biochemistry 31:4737-49