BioPAX pathway converted from "Exocytosis of platelet dense granule content" in the Reactome database. Exocytosis of platelet dense granule content Exocytosis of platelet dense granule content ADP is the most important constituent of dense granules, essential for recruiting platelets to the site of vascular injury. Other components include ATP, Ca++, GDP, GTP, Mg++, orthophospate, pyrophosphate, and serotonin. Authored: de Bono, B, Pace, N.P., Farndale, R, 2004-09-25 17:06:19 Converted from EntitySet in Reactome Reactome DB_ID: 481002 1 platelet dense granule lumen GO 0031089 Platelet dense granule content [platelet dense granule lumen] Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntity TIMP3 [platelet dense granule lumen] Mg2+ [platelet dense granule lumen] CTSW [platelet dense granule lumen] GTP [platelet dense granule lumen] FAM3C [platelet dense granule lumen] SPP2 [platelet dense granule lumen] APOH [platelet dense granule lumen] ATP [platelet dense granule lumen] SEPP1 [platelet dense granule lumen] LGALS3BP [platelet dense granule lumen] Ca2+ [platelet dense granule lumen] CLEC3B [platelet dense granule lumen] CDC37L1 [platelet dense granule lumen] Pi [platelet dense granule lumen] GDP [platelet dense granule lumen] PPi [platelet dense granule lumen] SERPINA4 [platelet dense granule lumen] ITIH4 [platelet dense granule lumen] ADP [platelet dense granule lumen] RARRES2 [platelet dense granule lumen] ITIH3 [platelet dense granule lumen] 5HT [platelet dense granule lumen] ECM1 [platelet dense granule lumen] Reactome http://www.reactome.org UniProt P35625 ChEBI 18420 UniProt P56202 ChEBI 15996 UniProt Q92520 UniProt Q13103 UniProt P02749 ChEBI 30616 UniProt P49908 UniProt Q08380 ChEBI 29108 UniProt P05452 UniProt Q7L3B6 ChEBI 43474 ChEBI 17552 ChEBI 33019 UniProt P29622 UniProt Q14624 ChEBI 456216 UniProt Q99969 UniProt Q06033 ChEBI 350546 UniProt Q16610 Converted from EntitySet in Reactome Reactome DB_ID: 481030 1 extracellular region GO 0005576 Platelet dense granule content [extracellular region] Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntity APOH [extracellular region] FAM3C [extracellular region] SPP2 [extracellular region] LGALS3BP [extracellular region] ATP [extracellular region] GTP [extracellular region] GDP [extracellular region] Ca2+ [extracellular region] 5HT [extracellular region] ITIH3 [extracellular region] Pi [extracellular region] CTSW [extracellular region] ADP [extracellular region] TIMP3 [extracellular region] Mg2+ [extracellular region] SEPP1 [extracellular region] RARRES2 [extracellular region] CLEC3B [extracellular region] ITIH4 [extracellular region] ECM1 [extracellular region] SERPINA4 [extracellular region] PPi [extracellular region] CDC37L1 [extracellular region] ChEBI 37565 ChEBI 58189 Reactome Database ID Release 82 481009 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=481009 Reactome R-HSA-481009 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-481009.3 19073150 Pubmed 2009 RhoA downstream of G(q) and G(12/13) pathways regulates protease-activated receptor-mediated dense granule release in platelets Jin, J Mao, Y Thomas, D Kim, S Daniel, JL Kunapuli, SP Biochem Pharmacol 77:835-44 1435334 Pubmed 1992 Isolation of dense granules from human platelets Fukami, MH Methods Enzymol 215:36-42 4132863 Pubmed 1974 Calcium-containing platelet granules Martin, JH Carson, FL Race, GJ J Cell Biol 60:775-7 4809565 Pubmed 1974 Serotonin storage in platelets: estimation of storage-packet size Costa, JL Reese, TS Murphy, DL Science 183:537-8 4426930 Pubmed 1974 The localization of calcium and phosphorus in human platelets Skaer, RJ Peters, PD Emmines, JP J Cell Sci 15:679-82