BioPAX pathway converted from "GLI1 binds HHIP gene, PTCH2 gene and BOC gene promoters" in the Reactome database.GLI1 binds HHIP gene, PTCH2 gene and BOC gene promotersGLI1 binds HHIP gene, PTCH2 gene and BOC gene promotersGenome-wide ChIP studies have identified Hh pathway members HHIP, PTCH2 and BOC as direct targets of GLI1 downstream of pathway activation (Vokes et al, 2007; Vokes et al, 2008; Lee et al, 2010). Authored: Rothfels, Karen, 2014-10-30Reviewed: Liu, Yulu Cherry, 2014-11-09Edited: Gillespie, Marc E, 2014-10-30Converted from EntitySet in ReactomeReactome DB_ID: 56350701nucleoplasmGO0005654HHIP gene,PTCH2 gene,BOC gene [nucleoplasm]Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntityBOC gene [nucleoplasm]HHIP gene [nucleoplasm]PTCH2 gene [nucleoplasm]Reactomehttp://www.reactome.orgHomo sapiensNCBI Taxonomy9606ENSEMBLENSG00000144857ENSEMBLENSG00000164161ENSEMBLENSG00000117425Reactome DB_ID: 56350571UniProt:P08151 GLI1GLI1GLIGLI1FUNCTION Acts as a transcriptional activator (PubMed:19706761, PubMed:10806483, PubMed:19878745, PubMed:24311597, PubMed:24217340). Binds to the DNA consensus sequence 5'-GACCACCCA-3' (PubMed:2105456, PubMed:8378770, PubMed:24217340). Regulates the transcription of specific genes during normal development (PubMed:19706761). Plays a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling (PubMed:19706761, PubMed:28973407). Plays a role in cell proliferation and differentiation via its role in SHH signaling (PubMed:11238441, PubMed:28973407).SUBUNIT Interacts with KIF7 (By similarity). Interacts with STK36 (PubMed:10806483). Interacts with ZIC1; the interaction enhances transcription activation (PubMed:11238441). Interacts with SUFU; this inhibits transcriptional activation by GLI1 (PubMed:10806483, PubMed:24311597, PubMed:24217340, PubMed:28965847).TISSUE SPECIFICITY Detected in testis (at protein level) (PubMed:2105456). Testis, myometrium and fallopian tube. Also expressed in the brain with highest expression in the cerebellum, optic nerve and olfactory tract (PubMed:19878745). Isoform 1 is detected in brain, spleen, pancreas, liver, kidney and placenta; isoform 2 is not detectable in these tissues (PubMed:19706761).INDUCTION Isoform 1 and isoform 2 are amplified in glioblastoma cells.PTM Phosphorylated in vitro by ULK3.PTM Acetylation at Lys-518 down-regulates transcriptional activity. Deacetylated by HDAC1.SIMILARITY Belongs to the GLI C2H2-type zinc-finger protein family.UniProtP08151phosphorylated residue at unknown positionphosphorylated residue [MOD:00696]phosphorylated residue at unknown positionChain Coordinates1EQUAL1106EQUALReactome DB_ID: 563507812p-GLI1:HHIP gene,PTCH2 gene,BOC gene [nucleoplasm]2p-GLI1:HHIP gene,PTCH2 gene,BOC geneConverted from EntitySet in ReactomeReactome DB_ID: 56350701Reactome DB_ID: 56350571phosphorylated residue at unknown positionphosphorylated residue at unknown position1EQUAL1106EQUALReactome Database ID Release 755635078Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5635078ReactomeR-HSA-56350781Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5635078.1Reactome Database ID Release 755635850Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5635850ReactomeR-HSA-56358502Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5635850.217442700Pubmed2007Genomic characterization of Gli-activator targets in sonic hedgehog-mediated neural patterningVokes, Steven AJi, HongkaiMcCuine, ScottTenzen, ToyoakiGiles, ShaneZhong, ShengLongabaugh, William J RDavidson, Eric HWong, Wing HMcMahon, Andrew PDevelopment 134:1977-8920460306Pubmed2010Hedgehog pathway-regulated gene networks in cerebellum development and tumorigenesisLee, Eunice YJi, HongkaiOuyang, ZhengqingZhou, BaiyuMa, WenxiuVokes, Steven AMcMahon, Andrew PWong, Wing HScott, Matthew PProc. Natl. Acad. Sci. U.S.A. 107:9736-4118832070Pubmed2008A genome-scale analysis of the cis-regulatory circuitry underlying sonic hedgehog-mediated patterning of the mammalian limbVokes, Steven AJi, HongkaiWong, Wing HMcMahon, Andrew PGenes Dev. 22:2651-63