BioPAX pathway converted from "CTF1 binds LIFR:JAKs" in the Reactome database.CTF1 binds LIFR:JAKsCTF1 binds LIFR:JAKsCardiotrophin-1 (CTF1/CT-1) is a member of the IL-6 family of cytokines which was originally discovered as a factor which can induce hypertrophy of cardiac myocytes both in vitro and in vivo (Pennica et al. 1995a). Subsequently, CTF1 has been shown to have a wide variety of different effects on cardiac and non cardiac cells including the ability to stimulate the survival of both cardiac and neuronal cells (Latchman 1999). Leukemia inhibitory factor (LIF), CTF1, and oncostatin M (OSM) are four helix bundle cytokines acting through a common heterodimeric receptor composed of gp130 and LIF receptor (LIFR) (Pennica et al. 1995b).Authored: Garapati, Phani Vijay, 2015-07-21Reviewed: Narazaki, M, Tanaka, M, 2015-11-09Edited: Garapati, Phani Vijay, 2015-07-21Reactome DB_ID: 56964371extracellular regionGO0005576UniProt:Q16619 CTF1CTF1CTF1FUNCTION Induces cardiac myocyte hypertrophy in vitro. Binds to and activates the ILST/gp130 receptor.TISSUE SPECIFICITY Highly expressed in heart, skeletal muscle, prostate and ovary. Lower levels in lung, kidney, pancreas, thymus, testis and small intestine. Little or no expression in brain, placenta, liver, spleen, colon or peripheral blood leukocytes.SIMILARITY Belongs to the IL-6 superfamily.Reactomehttp://www.reactome.orgHomo sapiensNCBI Taxonomy9606UniProtQ16619Chain Coordinates1EQUAL201EQUALReactome DB_ID: 67841981plasma membraneGO0005886JAKs:LIFR [plasma membrane]JAKs:LIFRConverted from EntitySet in ReactomeReactome DB_ID: 10676561cytosolGO0005829JAK1, JAK2, (TYK2) [cytosol]Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntityJAK1 [cytosol]JAK2 [cytosol]UniProtP23458UniProtO60674Reactome DB_ID: 56931811UniProt:P42702 LIFRLIFRLIFRFUNCTION Signal-transducing molecule. May have a common pathway with IL6ST. The soluble form inhibits the biological activity of LIF by blocking its binding to receptors on target cells.SUBUNIT Heterodimer composed of LIFR and IL6ST. The heterodimer formed by LIFR and IL6ST interacts with the complex formed by CNTF and CNTFR.DOMAIN The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.DOMAIN The box 1 motif is required for JAK interaction and/or activation.DISEASE A chromosomal aberration involving LIFR is found in salivary gland pleiomorphic adenomas, the most common benign epithelial tumors of the salivary gland. Translocation t(5;8)(p13;q12) with PLAG1.SIMILARITY Belongs to the type I cytokine receptor family. Type 2 subfamily.UniProtP4270245EQUAL1097EQUALReactome Database ID Release 756784198Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6784198ReactomeR-HSA-67841981Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-6784198.1Reactome DB_ID: 67835331CTF1:LIFR:JAKs [plasma membrane]CTF1:LIFR:JAKsReactome DB_ID: 569643711EQUAL201EQUALReactome DB_ID: 67841981Reactome Database ID Release 756783533Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6783533ReactomeR-HSA-67835331Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-6783533.1Reactome Database ID Release 755696482Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5696482ReactomeR-HSA-56964821Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5696482.17862649Pubmed1995Expression cloning of cardiotrophin 1, a cytokine that induces cardiac myocyte hypertrophyPennica, DKing, K LShaw, K JLuis, ERullamas, JLuoh, S MDarbonne, W CKnutzon, D SYen, RChien, K RProc. Natl. Acad. Sci. U.S.A. 92:1142-67738033Pubmed1995Cardiotrophin-1. Biological activities and binding to the leukemia inhibitory factor receptor/gp130 signaling complexPennica, DShaw, K JSwanson, T AMoore, M WShelton, D LZioncheck, K ARosenthal, ATaga, TPaoni, N FWood, W IJ. Biol. Chem. 270:10915-2211834704Pubmed2002Cardiotrophin-1 stimulation of cardiac fibroblast growth: roles for glycoprotein 130/leukemia inhibitory factor receptor and the endothelin type A receptorTsuruda, ToshihiroJougasaki, MichihisaBoerrigter, GuidoHuntley, Brenda KChen, Horng HD'Assoro, Antonino BLee, Shang CLarsen, Amy MCataliotti, AlessandroBurnett, John CCirc. Res. 90:128-3410583628Pubmed1999Cardiotrophin-1 (CT-1): a novel hypertrophic and cardioprotective agentLatchman, D SInt J Exp Pathol 80:189-96