BioPAX pathway converted from "IRAK2 phosphorylation bound to the activated TLR7 (or TLR21) complex" in the Reactome database. 2.7.11.1 IRAK2 phosphorylation bound to the activated TLR7 (or TLR21) complex IRAK2 phosphorylation bound to the activated TLR7 (or TLR21) complex In mammals activated IRAK4 phosphorylates both IRAK1 and IRAK2. Activated IRAK1 and IRAK2 in turn induce NFkB and AP-1 intracellular signaling cascades mediated by TRAF6.<p>Bioinformatic analysis reveals no evidence of IRAK1 in the chicken genome. It is possible that the chicken TLR pathway utilizes only IRAK-2, which shares 47% amino acid sequence identity with human IRAK2. Authored: Shamovsky, V, 2010-11-30 Reviewed: D'Eustachio, P, 2010-12-06 Edited: Shamovsky, V, 2011-02-24 Reactome DB_ID: 113592 2 cytosol GO 0005829 ATP(4-) [ChEBI:30616] ATP(4-) Adenosine 5'-triphosphate atp ATP Reactome http://www.reactome.org ChEBI 30616 Reactome DB_ID: 571321 1 endosome membrane GO 0010008 IRAK2:p-IRAK4:MyD88:activated TLR7 /or 21 complex [endosome membrane] IRAK2:p-IRAK4:MyD88:activated TLR7 /or 21 complex Reactome DB_ID: 993993 2 UniProt:Q5F382 RCJMB04_29d24 RCJMB04_29d24 RCJMB04_29d24 <submittedName> <fullName>Putative uncharacterized protein</fullName> </submittedName> Gallus gallus NCBI Taxonomy 9031 UniProt Q5F382 Chain Coordinates 1 EQUAL 691 EQUAL Reactome DB_ID: 451434 1 activated TLR7/or TLR21 : MyD88 : IRAK4 complex [endosome membrane] activated TLR7/or TLR21 : MyD88 : IRAK4 complex Reactome DB_ID: 993981 2 UniProt:Q5ZJM6 RCJMB04_17b10 RCJMB04_17b10 RCJMB04_17b10 <submittedName> <fullName>Putative uncharacterized protein</fullName> </submittedName> UniProt Q5ZJM6 1 EQUAL 373 EQUAL Reactome DB_ID: 451459 1 activated TLR7/ or TLR21 : MyD88 complex [endosome membrane] activated TLR7/ or TLR21 : MyD88 complex Reactome DB_ID: 573258 2 UniProt:A5HNF6 MYD88 MYD88 RCJMB04_14h3 MYD88 FUNCTION Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.TISSUE SPECIFICITY Expressed in spleen, liver, kidney, bursa of Fabricius, lung and brain (at protein level). Expressed in cecum, heart, spleen, liver, kidney, female reproductive tract, thymus, bursa of Fabricius, muscle and lung.DOMAIN The intermediate domain (ID) is required for the phosphorylation and activation of IRAK. UniProt A5HNF6 1 EQUAL 299 EQUAL Converted from EntitySet in Reactome Reactome DB_ID: 573279 1 activated TLR7 or 21 bound to ligand [endosome membrane] Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntity Reactome Database ID Release 82 451459 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=451459 Reactome R-GGA-451459 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-451459.1 Reactome Database ID Release 82 451434 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=451434 Reactome R-GGA-451434 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-451434.1 Reactome Database ID Release 82 571321 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=571321 Reactome R-GGA-571321 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-571321.1 Reactome DB_ID: 29370 2 ADP(3-) [ChEBI:456216] ADP(3-) ADP trianion 5&apos;-O-[(phosphonatooxy)phosphinato]adenosine ADP ChEBI 456216 Reactome DB_ID: 994003 1 p-IRAK2 : p-IRAK4 : MyD88: activated TLR7 or 21 [endosome membrane] p-IRAK2 : p-IRAK4 : MyD88: activated TLR7 or 21 Reactome DB_ID: 571317 1 activated TLR7/or TLR21: MyD88 : p-IRAK4 complex [endosome membrane] activated TLR7/or TLR21: MyD88 : p-IRAK4 complex Reactome DB_ID: 451459 1 Reactome DB_ID: 993980 2 O-phospho-L-serine at unknown position O-phospho-L-serine [MOD:00046] O-phospho-L-threonine at unknown position O-phospho-L-threonine [MOD:00047] 1 EQUAL 373 EQUAL Reactome Database ID Release 82 571317 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=571317 Reactome R-GGA-571317 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-571317.1 Reactome DB_ID: 994002 2 phosphorylated residue at unknown position phosphorylated residue [MOD:00696] phosphorylated residue at unknown position 1 EQUAL 691 EQUAL Reactome Database ID Release 82 994003 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=994003 Reactome R-GGA-994003 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-994003.1 PHYSIOL-LEFT-TO-RIGHT ACTIVATION Reactome DB_ID: 571321 GO 0004674 GO molecular function Reactome Database ID Release 82 571329 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=571329 Reactome Database ID Release 82 571327 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=571327 Reactome R-GGA-571327 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-571327.1 19224918 Pubmed 2009 Interleukin-1 receptor-associated kinase 2 is critical for lipopolysaccharide-mediated post-transcriptional control Wan, Y Xiao, H Affolter, J Kim, TW Bulek, K Chaudhuri, S Carlson, D Hamilton, T Mazumder, B Stark, GR Thomas, J Li, X J Biol Chem 284:10367-75 18438411 Pubmed 2008 Sequential control of Toll-like receptor-dependent responses by IRAK1 and IRAK2 Kawagoe, T Sato, S Matsushita, K Kato, H Matsui, Kuniko Kumagai, Y Saitoh, T Kawai, T Takeuchi, O Akira, Shizuo Nat Immunol 9:684-91 19539094 Pubmed 2009 The avian Toll-Like receptor pathway--subtle differences amidst general conformity Cormican, P Lloyd, AT Downing, T Connell, SJ Bradley, D O'Farrelly, C Dev Comp Immunol 33:967-73