BioPAX pathway converted from "Expression of IL4, IL13-upregulated extracellular proteins" in the Reactome database.Expression of IL4, IL13-upregulated extracellular proteinsExpression of IL4, IL13-upregulated extracellular proteinsIn human peripheral blood monocytes IL4 and IL13 significantly upregulate the levels of several extracellular proteins involved in inflammatory resolution including fibronectin (FN1), coagulation factor XIII (FXIII), annexin 1 (ANXA1), collagen type 1 alpha 2 (COL1A2), laminin alpha-5 (LAMA5) and C-C motif chemokine 22 (CCL22) (Chaitidis et al. 2005, Jinnin et al. 2004, Yakubenko et al. 2011).Authored: Jupe, Steve, 2015-07-01Reviewed: Leibovich, Samuel, 2016-09-02Edited: Jupe, Steve, 2016-09-02Converted from EntitySet in ReactomeReactome DB_ID: 67895051nucleoplasmGO0005654IL4,IL13-upregulated extracellular genes [nucleoplasm]Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntityCOL1A2 gene [nucleoplasm]ANXA1 gene [nucleoplasm]F13A1 gene [nucleoplasm]FN1 gene [nucleoplasm]CCL22 gene [nucleoplasm]LAMA5 gene [nucleoplasm]Reactomehttp://www.reactome.orgHomo sapiensNCBI Taxonomy9606ENSEMBLENSG00000164692ENSEMBLENSG00000135046ENSEMBLENSG00000124491ENSEMBLENSG00000115414ENSEMBLENSG00000102962ENSEMBLENSG00000130702Converted from EntitySet in ReactomeReactome DB_ID: 67895041extracellular regionGO0005576IL4,IL13-upregulated extracellular proteins [extracellular region]Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntityFN1(32-2386) [extracellular region]ANXA1 [extracellular region]COL1A2 [extracellular region]LAMA5 [extracellular region]factor XIII A chain [extracellular region]CCL22(25-93) [extracellular region]UniProtP02751UniProtP04083UniProtP08123UniProtO15230UniProtP00488UniProtO00626Reactome Database ID Release 716785895Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6785895ReactomeR-HSA-67858952Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-6785895.215869882Pubmed2005Gene expression alterations of human peripheral blood monocytes induced by medium-term treatment with the TH2-cytokines interleukin-4 and -13Chaitidis, PavlosO'Donnell, ValerieKuban, Ralf JBermudez-Fajardo, AlexandraUngethuem, UteKühn, HartmutCytokine 30:366-7715271999Pubmed2004Interleukin-13 stimulates the transcription of the human alpha2(I) collagen gene in human dermal fibroblastsJinnin, MasatoshiIhn, HironobuYamane, KenichiTamaki, KunihikoJ. Biol. Chem. 279:41783-9123124025Pubmed2013IL-4 and IL-13 employ discrete signaling pathways for target gene expression in alternatively activated monocytes/macrophagesBhattacharjee, AshishShukla, MeenakshiYakubenko, Valentin PMulya, AnnyKundu, SumanCathcart, Martha KFree Radic. Biol. Med. 54:1-1621252155Pubmed2011αMßâ‚‚ integrin activation prevents alternative activation of human and murine macrophages and impedes foam cell formationYakubenko, Valentin PBhattacharjee, AshishPluskota, ElzbietaCathcart, Martha KCirc. Res. 108:544-54ACTIVATIONReactome Database ID Release 716797277Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6797277ReactomeR-HSA-67972771Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-6797277.1Converted from EntitySet in ReactomeReactome DB_ID: 6797283IL4, IL13 [extracellular region]Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntityIL4 [extracellular region]IL13 [extracellular region]UniProtP05112UniProtP35225